Results 11 to 20 of about 7,025 (177)
Regulating Neutrophil PAD4/NOX-Dependent Cerebrovasular Thromboinflammation [PDF]
International Journal of Biological Sciences, 2023 Background: Neutrophil extracellular trap (NET) production has been implicated in the pathogenesis of thromboinflammatory conditions such as Sickle Cell Disease (SCD), contributing to heightened risk for ischemic stroke. NETs are catalyzed by the enzyme Peptidyl Arginine Deiminase 4 (PAD4) and neutrophil derived reactive oxygen species (ROS ...
Ansari, J +3 more
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Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors [PDF]
Bioorganic & Medicinal Chemistry, 2008 Protein Arginine Deiminase 4 (PAD4) has emerged as a leading target for the development of a Rheumatoid Arthritis (RA) pharmaceutical. Herein, we describe the development of a novel screen for PAD4 inhibitors that is based on a PAD4-targeted Activity-Based Protein Profiling reagent, denoted Rhodamine-conjugated F-Amidine (RFA).
Knuckley, Bryan +2 more
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PAD4 controls chemoattractant production and neutrophil trafficking in malaria [PDF]
Journal of Leukocyte Biology, 2021 AbstractPeptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role in regulation of immune cell trafficking and chemokine production. PAD4 regulates liver immunopathology by promoting neutrophil trafficking in
Cela, Drinalda +6 more
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Regulation of E2F1 by PAD4 mediated citrullination
, 2015 Peptidyl arginine deiminase (PAD) 4 is a nuclear enzyme that converts arginine residues to citrulline. PAD4 activity has been implicated in inflammatory disease and cancer, although its mechanism of action, particularly the identity of functionally relevant targets, remains unclear.
Fatemeh, Fatemeh A. Ghari Seyed +1 more
openaire +4 more sources
Functional Role of Dimerization of Human Peptidylarginine Deiminase 4 (PAD4)
PLoS ONE, 2011 Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca²⁺-dependent protein citrullination, which results in the conversion of arginine to citrulline. This paper demonstrates the functional role of dimerization in the regulation of PAD4 activity. To address this question, we created a series of dimer interface mutants of PAD4. The
Yi-Liang Liu +3 more
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Periodontitis and experimental arthritis in the absence of PAD4
, 2015 Objectives: There is evidence of a bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA), although the mechanisms underlying this relationship remain undefined. Both PD and RA are associated with inflammation and citrullination, a post-translational modification of proteins catalysed by peptidylarginine deiminases ...
Adrados-Planell, Ana +10 more
openaire +2 more sources
Infection with Porphyromonas gingivalis in the absence of PAD4
, 2014 Objectives:There is evidence of a bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA), although the mechanisms underlying this relationship remain undefined. Both PD and RA are associated with inflammation and citrullination, a post-translational modification of proteins catalysed by peptidylarginine deiminases ...
Butcher, John
openaire +2 more sources
The Arabidopsis TIR-NB-LRR GeneRAC1 confers resistance to Albugo candida (white rust) and is dependent on EDS1 but not PAD4 [PDF]
, 2004 Resistance to Albugo candida isolate Acem1 is conferred by a dominant gene, RAC1, in accession Ksk-1 of Arabidopsis thaliana. This gene was isolated by positional cloning and is a member of the Drosophila toll and mammalian interleukin-1 receptor (TIR ...
Rozwadowski, Kevin +4 more
core +1 more source
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate [PDF]
Rheumatology International, 2011 Isoform 4 of the human peptidylarginine deiminase (hPAD4) enzyme may be responsible for the citrullination of antigens in rheumatoid arthritis (RA) and has been shown to be itself the target of disease-specific autoantibodies. Here, we have tested whether the level of serum anti-hPAD4 antibodies in RA patients is stable over a period of 10 years and ...
Pollmann, Sylvie +6 more
openaire +2 more sources
Lupus and proliferative nephritis are PAD4 independent in murine models [PDF]
JCI Insight, 2017 Though recent reports suggest that neutrophil extracellular traps (NETs) are a source of antigenic nucleic acids in systemic lupus erythematosus (SLE), we recently showed that inhibition of NETs by targeting the NADPH oxidase complex via cytochrome b-245, β polypeptide (cybb) deletion exacerbated disease in the MRL.Faslpr lupus mouse model. While these
Rachael A. Gordon +10 more
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