Image_2_MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.tiff
, 2019 Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones.
Henrik Thorlacius (367502) +4 more
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PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis [PDF]
, 2012 Introduction Both murine and human genome-wide association studies have implicated peptidyl arginine deiminase (PAD4) as a susceptibility gene in rheumatoid arthritis (RA).
Hemmers, Saskia +9 more
core +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Purified protective antigen domain 4 (PAD4) can be successfully encapsulated in PLGA.
, 2013 The purified PAD4 from PAD4 expressing E.coli cells (Ni-NTA chromatography) that was used for making PAD4-NP by w/o/w method (left lane), PAD4 recovered from PAD4-NP (middle lane) and protein molecular weight ladder (right lane), were subjected to 10 ...
Manish Manish (408168) +4 more
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ERF transcription factor StPti5 is a regulator of endophyte community maintenance in potato
New Phytologist, EarlyView.Summary We have recently identified an ethylene response factor, StPti5, as a susceptibility factor that negatively regulates immune responses to diverse pathogens. Here, we investigated the role of StPti5 in the processes involved in the colonization of potato with beneficial organisms.
Tjaša Lukan +18 more
wiley +1 more source
PAD4-dependent NETs generation are indispensable for intestinal clearance of Citrobacter rodentium [PDF]
Mucosal Immunology, 2019 Peptidyl arginine deiminase-4 (PAD4) is indispensable for generation of neutrophil extracellular traps (NETs), which can provide antimicrobial effects during host innate immune response; however, the role of PAD4 against gastrointestinal infection is largely unknown.
Saha, Piu +6 more
openaire +2 more sources
The role of PAD4 in periodontal disease, autoimmunity and inflammation [PDF]
, 2017 Periodontal disease (PD) and rheumatoid arthritis (RA) are multifactorial chronic inflammatory diseases with high prevalence among the global population.
Adrados Planell, Ana
core
LURP1, a SARD1‐regulated protein, coordinates with the helper NLR ADR1 to promote plant immunity
New Phytologist, EarlyView.The working model of LURP1 function in plant immunity. Upon pathogen infection, SARD1/CBP60g promotes the transcription of LURP1 directly. LURP1 likely functions as an adaptor protein that associates with the PRRs–BAK1 complexes at the plasma membrane (PM) while also interacts with the ADR1 family helper NLRs.
Xueru Liu +7 more
wiley +1 more source
Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis
Scandinavian Journal of Rheumatology, 2019 Objectives: Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes catalysing the conversion of arginine residues to citrulline, which may constitute a risk factor in rheumatoid arthritis (RA) pathogenesis. We investigated PAD activation by serum (PADAct) in early RA, and the associations between PAD activation and disease ...
Jonsson, M. K. +9 more
openaire +3 more sources
Divergent roles for kidney proximal tubule and granulocyte PAD4 in ischemic AKI
, 2018 We previously demonstrated that kidney peptidylarginine deiminase-4 (PAD4) plays a critical role in ischemic acute kidney injury (AKI) in mice by promoting renal tubular inflammation and neutrophil infiltration (Ham A, Rabadi M, Kim M, Brown KM, Ma Z, D’
Sang Jun Han +6 more
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