Results 51 to 60 of about 6,359 (194)

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3

Frontiers in Immunology, 2018
Neutrophil extracellular trap (NET) formation requires chromatin decondensation before nuclear swelling and eventual extracellular release of DNA, which occurs together with nuclear and cytoplasmic antimicrobial proteins.
Heather L. Clark, Heather L. Clark, Heather L. Clark, Serena Abbondante, Serena Abbondante, Martin S. Minns, Martin S. Minns, Elyse N. Greenberg, Elyse N. Greenberg, Yan Sun, Eric Pearlman, Eric Pearlman   +11 more
doaj   +1 more source

Immunomodulatory Nanozymes as Programmable Redox–Immune Set‐Point Regulators

Small, EarlyView.
Conceptual phase space linking reactive oxygen species level/dynamics to immune state, with pathological set‐points for chronic inflammation, tumor escape, and degeneration contrasted against a central healthy redox–immune set‐point. Buffering and amplifying nanozymes are depicted as devices that dial redox tone up or down to steer diseased ...
Sumi Choi, Minjeong Kim, Sang Jin Lee, Su‐Hwan Kim   +3 more
wiley   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Functional roles of the non-catalytic calcium-binding sites in the N-terminal domain of human peptidylarginine deiminase 4. [PDF]

PLoS ONE, 2013
This study investigated the functional roles of the N-terminal Ca(2+) ion-binding sites, in terms of enzyme catalysis and stability, of peptidylarginine deiminase 4 (PAD4).
Yi-Liang Liu, I-Chen Tsai, Chia-Wei Chang, Ya-Fan Liao, Guang-Yaw Liu, Hui-Chih Hung   +5 more
doaj   +1 more source

Activated CCG10‐NLR: Octameric resistosome driving sustained calcium influx

Journal of Integrative Plant Biology, EarlyView.
This commentary spotlights landmark work from Guo et al. resolving the structure of the octameric resistosome formed by the active CCG10‐nucleotide‐binding leucine‐rich repeat (NLR) immune receptor WAI3, which triggers sustained, multi‐phasic Ca2+ influx.
Huayue Sun, Xiaohuan Jin, Mengchen Hu, Daowen Wang, Zheng Qing Fu   +4 more
wiley   +1 more source

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2014
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Creutzfeldt-Jacob's disease and cancer.
TRABOCCHI, ANDREA, N. Pala, I. Krimmelbein, MENCHI, GLORIA, GUARNA, ANTONIO, M. Sechi, T. Dreker, SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR, CARTA, FABRIZIO   +9 more
openaire   +5 more sources

Probing the Roles of Calcium-Binding Sites during the Folding of Human Peptidylarginine Deiminase 4

Scientific Reports, 2017
Our recent studies of peptidylarginine deiminase 4 (PAD4) demonstrate that its non-catalytic Ca2+-binding sites play a crucial role in the assembly of the correct geometry of the enzyme. Here, we examined the folding mechanism of PAD4 and the role of Ca2+
Yi-Liang Liu, Chien-Yun Lee, Yu-Ni Huang, Hui-Yi Chen, Guang-Yaw Liu, Hui-Chih Hung   +5 more
doaj   +1 more source

RING E3 ligase SNIPER8 functions redundantly with three close homologs to regulate the turnover of transcriptional co‐repressor TPR1

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis E3 ligase SNIPER8 negatively regulates immunity by promoting ubiquitination and proteasomal degradation of the transcriptional corepressor TOPLESS‐RELATED1, limiting excessive immune responses, maintaining immune homeostasis, and balancing defense activation and normal plant growth.
Xueru Liu, Paul Kapos, Zhongshou Wu, Yujun Peng, Meixuezi Tong, Asana Khajavi, Yan Huang, Yuelin Zhang, Xin Li   +8 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source