Results 51 to 60 of about 7,025 (177)
Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity
Plant, Cell &Environment, EarlyView.ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette +5 more
wiley +1 more source
, 2018 We previously demonstrated that renal tubular peptidylarginine deiminase-4 (PAD4) is induced after ischemia-reperfusion (IR) injury and this induction of PAD4 exacerbates ischemic acute kidney injury (AKI) by promoting renal tubular inflammation and ...
Sang Jun Han +6 more
core +1 more source
Targeting PAD4: A Promising Strategy to Combat β-Cell Loss in Type 1 Diabetes [PDF]
Peptidylarginine deiminase 4 (PAD4) catalyzes protein citrullination, a post-translational modification implicated in type 1 diabetes mellitus (T1DM).
Kupai Krisztina +5 more
core +2 more sources
Plant Biology, EarlyView.We generated a compound by chemical modification that can efficiently rescue growth without decreasing the immune response of the chs3‐2D autoimmune mutants, thus chemically uncoupling its growth–defence trade‐off. Abstract Plant development in many species including Arabidopsis relies on the accurate balance between growth and defence.
M. Keijzer +5 more
wiley +1 more source
Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases
Periodontology 2000, EarlyView.Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva +2 more
wiley +1 more source
Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective
Periodontology 2000, EarlyView.Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh +3 more
wiley +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Surface morphology of PAD4-NP.
, 2013 The PLGA encapsulated PAD4 nanoparticles were visualized for surface morphology: (A) A scanning electron microscopy image (scale bar is 200 nm) (B) A transmission electron microscopy image (scale bar is 100 nm).
Manish Manish (408168) +4 more
core +1 more source
The role of neutrophils in the pathophysiology of inflammatory bowel diseases
Periodontology 2000, EarlyView.Abstract Objectives Inflammatory bowel disease (IBD) encompasses a spectrum of chronic disorders of the gastrointestinal tract, with a potential bidirectional relationship with periodontitis. Neutrophils are key regulators of immune‐inflammatory responses and play a major role in both diseases.
Joao Paulo Steffens +8 more
wiley +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source