Results 31 to 40 of about 7,025 (177)

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury [PDF]

Circulation Research, 2018
Rationale: Neutrophils likely contribute to the thrombotic complications of human atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal injury and thrombosis. PAD4 (peptidyl arginine deiminase 4) participates in
Franck, Grégory, Mawson, Thomas L, Folco, Eduardo J, Molinaro, Roberto, Ruvkun, Victoria, Engelbertsen, Daniel, Liu, Xin, Tesmenitsky, Yevgenia, Shvartz, Eugenia, Sukhova, Galina K, Michel, Jean-Baptiste, Nicoletti, Antonino, Lichtman, Andrew, Wagner, Denisa, Croce, Kevin J, Libby, Peter   +15 more
openaire   +2 more sources

Image_1_MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.tiff

, 2019
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones.
Henrik Thorlacius (367502), Amr Al-Haidari (7623308), Milladur Rahman (444686), Avin Hawez (7623305), Raed Madhi (7623311)   +4 more
core   +1 more source

Image_4_MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.tif

, 2019
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones.
Henrik Thorlacius (367502), Amr Al-Haidari (7623308), Milladur Rahman (444686), Avin Hawez (7623305), Raed Madhi (7623311)   +4 more
core   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Hypoxia‐preconditioned adipose‐derived mesenchymal stem cells‐derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5‐mediated inactivation of TLR4/NF‐κB/NLRP3 inflammatory signaling

Journal of Diabetes Investigation, EarlyView.
In this study, we uncovered that Hypo‐Exo transferring H19 promoted diabetic wound healing by repressing NETs formation via the miR‐130a/b‐3p/HOXA5 pathway to inactivate the TLR4/NF‐κB/NLRP3 inflammatory signaling. ABSTRACT Background Hypoxia‐stimulated adipose‐derived mesenchymal stem cells (ADSCs)‐derived exosomes (Hypo‐Exo) have a positive impact on
Li Qian, Xianxi Meng, Bairong Fang, Li Pi   +3 more
wiley   +1 more source

MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps

, 2019
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones.
Rahman, Milladur,, Thorlacius, Henrik,, Thorlacius, Henrik, Hawez, Avin,, Madhi, Raed, Rahman, Milladur, Madhi, Raed,, Al-Haidari, Amr, Al-Haidari, Amr,, Lund University., Hawez, Avin   +10 more
core   +1 more source

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, EarlyView.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Image_3_MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps.tiff

, 2019
Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones.
Henrik Thorlacius (367502), Amr Al-Haidari (7623308), Milladur Rahman (444686), Avin Hawez (7623305), Raed Madhi (7623311)   +4 more
core   +1 more source

RETRACTED ARTICLE: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

, 2021
Background Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating disease process. Radiotherapy is an
Min Luo, Ting Liang, Lining Wei, Hao Chen, Changjie Huang, Xiangping Wang, Chaoyuan Huang   +6 more
core   +1 more source

Activated CCG10‐NLR: Octameric resistosome driving sustained calcium influx

Journal of Integrative Plant Biology, EarlyView.
This commentary spotlights landmark work from Guo et al. resolving the structure of the octameric resistosome formed by the active CCG10‐nucleotide‐binding leucine‐rich repeat (NLR) immune receptor WAI3, which triggers sustained, multi‐phasic Ca2+ influx.
Huayue Sun, Xiaohuan Jin, Mengchen Hu, Daowen Wang, Zheng Qing Fu   +4 more
wiley   +1 more source