Results 31 to 40 of about 8,135 (207)

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Opposition between PKC Isoforms Regulates Histone Deimination and Neutrophil Extracellular Chromatin Release

Frontiers in Immunology, 2013
In response to inflammation, neutrophils deiminate histones and externalize chromatin. Neutrophil extracellular traps (NETs) are an innate immune defense mechanism, yet NETs also may aggravate chronic inflammatory and autoimmune disorders.
Marko eRadic, Indira eNeeli
doaj   +1 more source

Preliminary study on the role of peptidyl arginine deiminase 4 in the regulation of maxillofacial development [PDF]

Kouqiang yixue
Objective To investigate the effect of peptidyl arginine deiminase 4(PAD4) on the differentiation of mesenchymal stem cells isolated from oral bones(OMSC) and craniomaxillofacial development.
YAN Xingzhi, CAI Xinyu, CHEN Simai, FANG Weiwen, LEI Fan, CAO Dan, ZHANG Yang
doaj   +1 more source

Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. [PDF]

PLoS ONE, 2018
OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).
Dres Damgaard, Mandar Bawadekar, Ladislav Senolt, Allan Stensballe, Miriam A Shelef, Claus H Nielsen   +5 more
doaj   +1 more source

The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis

Frontiers in Immunology, 2023
BackgroundNeutrophil extracellular traps (NETs) play an important role in the development and progression of ulcerative colitis (UC). Peptidyl arginine deiminase 4 (PAD4) is essential for the formation of NETs via catalyzing histone citrullination.
Ping Wang, Dan Liu, Ziqi Zhou, Fangjun Liu, Yiming Shen, Qi You, Shiping Lu, Jie Wu   +7 more
doaj   +1 more source

Activation of PAD4 in NET formation [PDF]

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates.
Rohrbach, Amanda S., Mowen, Kerri A., Thompson, Paul R, Slade, Daniel J.   +3 more
core   +1 more source

How RA Associated HLA-DR Molecules Contribute to the Development of Antibodies to Citrullinated Proteins: The Hapten Carrier Model

Frontiers in Immunology, 2022
The risk to develop ACPA positive rheumatoid arthritis (RA), the most destructive type of autoimmune arthritis, is carried by HLA-DRB1 alleles containing a 5 amino acid motif: the shared epitope (SE).
Jean Roudier, Jean Roudier, Jean Roudier, Nathalie Balandraud, Nathalie Balandraud, Isabelle Auger, Isabelle Auger   +6 more
doaj   +1 more source

GIGANTEA regulates PAD4 transcription to promote pathogen defense against Hyaloperonospora arabidopsidis in Arabidopsis thaliana

Plant Signaling & Behavior, 2022
Plants have evolved a network of complex signaling pathways that allow them to cope with the fluctuations of internal and external environmental cues.
Anamika Singh
doaj   +1 more source

Outcomes of sepsis: a new look at old problems

Медицинская иммунология, 2022
Infections represent a common health problem in people at any age. Usually, a local reaction develops in response to the infection, and intensive treatment is not required.
A. Yu. Savochkina, L. R. Pykhova, O. S. Abramovskikh, E. A. Chetvernina, A. E. Poltorak   +4 more
doaj   +1 more source

Infection with Porphyromonas gingivalis in the absence of PAD4

, 2014
Objectives:There is evidence of a bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA), although the mechanisms underlying this relationship remain undefined. Both PD and RA are associated with inflammation and citrullination, a post-translational modification of proteins catalysed by peptidylarginine deiminases ...
Butcher, John
openaire   +2 more sources