Results 21 to 30 of about 8,135 (207)

Periodontitis and experimental arthritis in the absence of PAD4

, 2015
Objectives: There is evidence of a bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA), although the mechanisms underlying this relationship remain undefined. Both PD and RA are associated with inflammation and citrullination, a post-translational modification of proteins catalysed by peptidylarginine deiminases ...
Adrados-Planell, Ana, Butcher, John, Mowen, Kerri, Hemmers, Saskia, Campbell, Lauren, Oliver-Bell, Jessica, Malcolm, Jennifer, Millhouse, Emma, McInnes, Iain, Garside, Paul, Culshaw, Shauna   +10 more
core   +5 more sources

Serum anti-PAD4 autoantibodies are present in cystic fibrosis children and increase with age and lung disease severity

Autoimmunity, 2022
Cystic fibrosis (CF) lung disease begins early in childhood and is characterized by neutrophilic inflammation of the airways. Neutrophil extracellular traps (NETs) represent one mechanism by which neutrophils contribute to lung damage.
Rachel W. Linnemann, Ruchi Yadav, Chao Zhang, Demba Sarr, Balázs Rada, Arlene A. Stecenko   +5 more
doaj   +1 more source

Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4

Scientific Reports, 2023
Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka   +6 more
doaj   +1 more source

Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis

Arthritis Research & Therapy, 2021
Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and ...
M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane, Erika Darrah   +8 more
doaj   +1 more source

Anti-PAD4 antibodies link autoimmunity to PAD4 with CTL-associated rheumatoid arthritis. [PDF]

Ann Rheum Dis
Ananth K, Moosic KB, Gomez-Banuelos E, Wang H, Trejo-Zambrano I, Johnson R, Kirschmann JM, Deddens T, Elghawy O, Shemo B, Robinson WH, Kimpel D, Bingham CO, Feith DJ, Antiochos B, Andrade F, Loughran TP, Darrah E.   +17 more
europepmc   +2 more sources

SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus. [PDF]

PLoS Pathogens, 2011
EDS1, PAD4, and SAG101 are common regulators of plant immunity against many pathogens. EDS1 interacts with both PAD4 and SAG101 but direct interaction between PAD4 and SAG101 has not been detected, leading to the suggestion that the EDS1-PAD4 and EDS1 ...
Shifeng Zhu, Rae-Dong Jeong, Srivathsa C Venugopal, Ludmila Lapchyk, DuRoy Navarre, Aardra Kachroo, Pradeep Kachroo   +6 more
doaj   +1 more source

A single-dose PLGA encapsulated protective antigen domain 4 nanoformulation protects mice against Bacillus anthracis spore challenge. [PDF]

PLoS ONE, 2013
Bacillus anthracis, the etiological agent of anthrax, is a major bioterror agent. Vaccination is the most effective prophylactic measure available against anthrax. Currently available anthrax vaccines have issues of the multiple booster dose requirement,
Manish Manish, Amit Rahi, Manpreet Kaur, Rakesh Bhatnagar, Samer Singh   +4 more
doaj   +1 more source

Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4

Scientific Reports, 2023
Protein arginine deiminases (PAD) 4 is an enzyme that catalyzes citrullination of protein and its role in autoimmune diseases has been established through clinical genetics and gene knock out studies in mice.
Chandru Gajendran, Shoichi Fukui, Naveen M. Sadhu, Mohammed Zainuddin, Sridharan Rajagopal, Ramachandraiah Gosu, Sarah Gutch, Saeko Fukui, Casey E. Sheehy, Long Chu, Santosh Vishwakarma, D. A. Jeyaraj, Gurulingappa Hallur, Denisa D. Wagner, Dhanalakshmi Sivanandhan   +14 more
doaj   +1 more source

RETRACTED ARTICLE: Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

Cellular & Molecular Biology Letters, 2021
Background Nasopharyngeal carcinoma (NPC) is a tumor deriving from nasopharyngeal epithelium. Peptidyl-arginine deiminase 4 (PAD4) is a vital mediator of histone citrullination and plays an essential role in regulating disease process. Radiotherapy is an
Hao Chen, Min Luo, Xiangping Wang, Ting Liang, Chaoyuan Huang, Changjie Huang, Lining Wei   +6 more
doaj   +1 more source

The Arabidopsis TIR-NB-LRR GeneRAC1 confers resistance to Albugo candida (white rust) and is dependent on EDS1 but not PAD4 [PDF]

, 2004
Resistance to Albugo candida isolate Acem1 is conferred by a dominant gene, RAC1, in accession Ksk-1 of Arabidopsis thaliana. This gene was isolated by positional cloning and is a member of the Drosophila toll and mammalian interleukin-1 receptor (TIR ...
Rozwadowski, Kevin, Borhan, Mohammad H., Holub, E. B., Rimmer, Samuel Roger, Beynon, Jim   +4 more
core   +1 more source