Results 21 to 30 of about 6,359 (194)
Plant Signaling & Behavior, 2022 Plants have evolved a network of complex signaling pathways that allow them to cope with the fluctuations of internal and external environmental cues.
Anamika Singh
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Outcomes of sepsis: a new look at old problems
Медицинская иммунология, 2022 Infections represent a common health problem in people at any age. Usually, a local reaction develops in response to the infection, and intensive treatment is not required.
A. Yu. Savochkina +4 more
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Frontiers in Immunology, 2013 In response to inflammation, neutrophils deiminate histones and externalize chromatin. Neutrophil extracellular traps (NETs) are an innate immune defense mechanism, yet NETs also may aggravate chronic inflammatory and autoimmune disorders.
Marko eRadic, Indira eNeeli
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Frontiers in Immunology, 2023 BackgroundNeutrophil extracellular traps (NETs) play an important role in the development and progression of ulcerative colitis (UC). Peptidyl arginine deiminase 4 (PAD4) is essential for the formation of NETs via catalyzing histone citrullination.
Ping Wang +7 more
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Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3. [PDF]
PLoS ONE, 2018 OBJECTIVE:Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).
Dres Damgaard +5 more
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PAD4 controls chemoattractant production and neutrophil trafficking in malaria [PDF]
Journal of Leukocyte Biology, 2021 AbstractPeptidylarginine deiminase 4 (PAD4) is a key regulator of inflammation but its function in infections remains incompletely understood. We investigate PAD4 in the context of malaria and demonstrate a role in regulation of immune cell trafficking and chemokine production. PAD4 regulates liver immunopathology by promoting neutrophil trafficking in
Cela, Drinalda +6 more
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Profibrotic impact of PAD4-driven macrophage extracellular traps in ulcerative colitis
Pharmacological ResearchThe inflammatory polarization of macrophages has been implicated in the pathogenesis of fibrosis in ulcerative colitis (UC). Our previous study found that macrophages in an inflammatory polarization state highly express peptidyl arginine deiminase 4 ...
Zhiwei Wang +8 more
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Arthritis Research & Therapy, 2018 Background Defining environmental factors responsible for development of autoimmunity in rheumatoid arthritis (RA) is critical for understanding mechanisms of disease initiation and propagation. Notably, a history of cigarette smoking has been implicated
Laura C. Cappelli +4 more
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Regulating Neutrophil PAD4/NOX-Dependent Cerebrovasular Thromboinflammation
International Journal of Biological Sciences, 2023 Background: Neutrophil extracellular trap (NET) production has been implicated in the pathogenesis of thromboinflammatory conditions such as Sickle Cell Disease (SCD), contributing to heightened risk for ischemic stroke. NETs are catalyzed by the enzyme Peptidyl Arginine Deiminase 4 (PAD4) and neutrophil derived reactive oxygen species (ROS ...
Ansari, J +3 more
openaire +4 more sources
Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4). [PDF]
PLoS ONE, 2011 Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca²⁺-dependent protein citrullination, which results in the conversion of arginine to citrulline.
Yi-Liang Liu +3 more
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