Results 21 to 30 of about 7,025 (177)

Arabidopsis EDR1 Protein Kinase Regulates the Association of EDS1 and PAD4 to Inhibit Cell Death [PDF]

, 2020
ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) and PHYTOALEXIN DEFICIENT4 (PAD4) are sequence-related lipase-like proteins that function as a complex to regulate defense responses in Arabidopsis by both salicylic acid–dependent and independent pathways.
Rodibaugh, N, Bhandari, D., Neubauer, M., Bautor, J., Bautor, J, Serrano, I., Rodibaugh, N., Bhandari, D, Neubauer, M P, Innes, R., Serrano, I M, Parker, J E, Parker, J., Innes, Roger William   +13 more
core   +2 more sources

Mapping benefit, risk, and opportunity in PAD4 inhibition [PDF]

Front Immunol
Peptidylarginine deiminase 4 (PAD4) is increasingly targeted to modulate inflammatory pathology, yet its inhibition produces biological effects that extend beyond the processes it was originally designed to suppress. While PAD4 targeting has largely been pursued to limit neutrophil extracellular trap (NET) formation, accumulating data indicate that ...
Santos Bonilha C, Protasio Veras F.
europepmc   +3 more sources

Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2014
The protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme, which catalyses the irreversible conversion of peptidyl-arginines into peptidyl-citrullines and plays an important role in several diseases such as in the rheumatoid arthritis, multiple sclerosis, Alzheimer's disease, Creutzfeldt-Jacob's disease and cancer.
TRABOCCHI, ANDREA, N. Pala, I. Krimmelbein, MENCHI, GLORIA, GUARNA, ANTONIO, M. Sechi, T. Dreker, SCOZZAFAVA, ANDREA, SUPURAN, CLAUDIU TRANDAFIR, CARTA, FABRIZIO   +9 more
openaire   +4 more sources

Effect of PAD4 on Nasopharyngeal Carcinoma and Nasopharyngeal Carcinoma Cells [PDF]

Indian Journal of Pharmaceutical Sciences, 2020
The purpose of this study was to evaluate the expression of PAD4 in nasopharyngeal carcinoma and to explore the relationship between PAD4 and the basic characteristics of 5-8F cells. Immunohistochemistry was used to evaluate the overexpression of the PAD4 protein in the nasopharyngeal carcinoma tissue of 30 patients diagnosed by biopsy in the Third ...
XIANGPING WANG, CHANGJIE HUANG, H. CHEN
openaire   +1 more source

PAD4-NP elicits an enhanced immune response.

, 2013
Swiss Webster outbred mice were immunized with a single-dose of PAD4 or PAD4-NP (n = 8). The sera from immunized mice were collected on day 14 and day 28 post immunization.
Manish Manish (408168), Rakesh Bhatnagar (408171), Manpreet Kaur (408170), Samer Singh (408172), Amit Rahi (408169)   +4 more
core   +1 more source

Structural basis for Ca²⁺-induced activation of human PAD4 [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2004
Peptidylarginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the conversion of protein arginine residues to citrulline. Its gene is a susceptibility locus for rheumatoid arthritis. Here we present the crystal structure of Ca(2+)-free wild-type PAD4, which shows that the polypeptide chain adopts an elongated fold in which the N ...
Kyouhei, Arita, Hiroshi, Hashimoto, Toshiyuki, Shimizu, Katsuhiko, Nakashima, Michiyuki, Yamada, Mamoru, Sato   +5 more
openaire   +2 more sources

Physical characterization of PAD4-NP.

, 2013
A diluted preparation of PAD4-NP (0.1 mg/ml) was used for the estimation of particle size (A) and zeta potential (B). The z-average (d. nm) of PAD4-NP nanoparticles was 230.9 nm with peak at 244.8 nm and width of 59.06 nm.
Manish Manish (408168), Rakesh Bhatnagar (408171), Manpreet Kaur (408170), Samer Singh (408172), Amit Rahi (408169)   +4 more
core   +1 more source

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination [PDF]

, 2019
Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA.
Mitesh Nagar, Ronak Tilvawala, Paul R. Thompson   +2 more
core   +2 more sources

Activation of PAD4 in NET formation

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates.
Rohrbach, Amanda S., Mowen, Kerri A., Thompson, Paul R, Slade, Daniel J.   +3 more
core   +1 more source

Direct interacting between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4 [PDF]

, 2001
The Arabidopsis EDS1 and PAD4 genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. Phenotypic analysis of eds1 and pad4 null mutants shows that EDS1 and PAD4 are required for resistance ...
Feys, Bart J., Newman, Mari Anne, Moisan, Lisa J., Parker, Jane E., Parker, J. E., Feys, B. J., Moisan, L. J., Newman, Mari-Anne   +7 more
core   +1 more source