Results 61 to 70 of about 7,025 (177)

Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor [PDF]

, 2018
Protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine to citrulline within target proteins. Dysregulation of PAD4 has been implicated in a number of human diseases, including rheumatoid arthritis and ...
Jonathan A. Ellman, Jamali, Haya, Jonathan A. Ellman (610362), Ellman, Jonathan A, Tjin, Caroline Chandra, Caroline Chandra Tjin (5777921), Rebecca F. Wissner (1868563), Haya Jamali, Wissner, Rebecca F, Alanna Schepartz (1327725), Schepartz, Alanna, Caroline Chandra Tjin, Alanna Schepartz, Haya Jamali (1432639), Rebecca F. Wissner   +14 more
core   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

, 2015
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice.
Kevin L Bicker, Davis, Rob P., Kenneth E Lind, Slade, Daniel J., Yu Hua Chen, Prinjha, Rab K., Wilson, David M., Bicker, Kevin L., Ryan P Bingham, Maller, Claire, Wagner, Denisa D., Claire Maller, Martinod, Kim, Joberty, Gerard, Gerard Joberty, Craggs, Peter D., Rüdiger, Martin, Cecil E Rise, Thompson, Paul R., Polyakova, Oxana, Benjamin D Bax, Stephen J Atkinson, Jim Thorpe, Eberhard, Dirk, Atkinson, Stephen J., Locke, Kelly, Thorpe, Jim, Chris Patten, Dirk Eberhard, Thomas, Pamela, Denisa D Wagner, Bax, Benjamin D., Lind, Kenneth E., Robert J Sheppard, Barker, Michael D., Martin Rüdiger, Pamela Thomas, Yao, Gang, Bax, Benjamin, D., Daniel J Slade, Rab K Prinjha, Sheppard, Robert J., Jim E Coote, Martinod, Kimberly, Lewis, Huw D., John Liddle, Rise, Cecil E, Wagner, Denisa, Gerard Drewes, Campbell, Matthew, Matthew Campbell, Bingham, Ryan P., Drewes, Gerard, Rise, Cecil E., Kimberly Martinod, Oxana Polyakova, Peter D Craggs, Huw D Lewis, Michael D Barker, Liddle, John, Patten, Chris, Chen, Yu Hua, Chung, Chun-wa, Rob P Davis, Chun-wa Chung, Paul R Thompson, David M Wilson, Gang Yao, Coote, Jim E., Kelly Locke   +69 more
core   +1 more source

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4).

, 2018
Citrullination is a post-translational modification (PTM) that serves many normal physiological functions. Studies have shown that this PTM-along with expression of the catalyzing enzymes, peptidyl arginine deiminases (PADs)-are increased in autoimmune ...
Beranova-Giorgianni, Sarka, Hollingsworth, TJ, Giorgianni, Francesco, Wang, Yanming, Radic, Marko Z, Iannaccone, Alessandro   +5 more
core   +1 more source

Role and intervention of PAD4 in NETs in acute respiratory distress syndrome

Respiratory Research
Abstract Background Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Acute respiratory distress syndrome (ARDS) is a common sepsis-associated injury that can increase postoperative mortality but the mechanism is still unclear. Main text
Xiaojie Liu, Tianjun Li, Huailong Chen, Li Yuan, Hushan Ao   +4 more
openaire   +3 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Plant defense against aphids: The PAD4 signalling nexus

, 2014
In Arabidopsis thaliana, PHYTOALEXIN DEFICIENT 4 (PAD4) functions as a key player in modulating defense against the phloem sap-feeding aphid Myzus persicae (Sülzer), more commonly known as the green peach aphid (GPA), an important pest of a wide variety ...
Shah, Jyoti, Louis, Joe
core  

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

New Insights Into the Role of Neutrophils in Lymphoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
Tissue‐resident neutrophils challenge conventional paradigms by actively infiltrating normal lymphoid organs, predominantly localizing in interstitial compartments, a spatial distribution distinct from their classical vascular positioning. Neutrophils in lymphoid organs exhibit unique phenotypic and functional signatures, suggesting they play roles in ...
Ling Gu
wiley   +1 more source

Structural Basis for Ca2+-induced Activation for Human PAD4

Nihon Kessho Gakkaishi, 2005
Peptidylarginine deimianse 4 (PAD4) is a Ca2+-dependent enzyme that catalyzes the conversion of both arginine and mono-methyl arginine in histones into citrullines, and regulates both histone argininine methylation level and gene activity. Its gene is susceptibility locus for rheumatoid arthritis (RA) .
ARITA, Kyouhei, SATO, Mamoru
openaire   +2 more sources