Results 81 to 90 of about 7,025 (177)

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

, 2010
Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with ...
Ming Li, Michael R. Lindberg, Pingxin Li, Na Xiong, Yanming Wang, Mary J. Kennett   +5 more
core   +1 more source

Data_Sheet_1_Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination.docx

, 2019
Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA.
Ronak Tilvawala (1453684), Paul R. Thompson (105487), Mitesh Nagar (1487254)   +2 more
core   +1 more source

Characterization of the sobir6–1 bir1–1 pad4–1 triple mutant.

, 2015
(A) Morphology of Col-0 wild type (WT), bir1–1, bir1–1 pad4–1 and sobir6–1 bir1–1 pad4–1. Plants were grown on soil at 23°C and photographed three weeks after planting.
Tongjun Sun (702739), Yuelin Zhang (215525), Qian Zhang (49333)   +2 more
core   +1 more source

Impact of reversible inhibitor binding to protein Arginine Deiminase Type 4 (PAD4): Molecular Dynamics Simulation and Mmpbsa Calculation

, 2022
PAD4 catalyses the conversion of peptidylarginine into peptidylcitrulline. Overexpression of PAD4 and the peptidylcitrulline products have been reported in various diseases including rheumatoid arthritis and cancers.
Zainal Fithri, Helmi Husaini, Ibrahim, Zalikha, Ali, Ernie Zuraida   +2 more
core  

Characterization of the stt3a-2 bir1–1 pad4–1 triple mutant.

, 2015
(A) Morphology of wild type (WT), bir1–1, bir1–1 pad4–1 and stt3a-2 bir1–1 pad4–1 plants. Plants were grown on soil at 23°C and photographed 3 weeks after planting.
Tongjun Sun (702739), Yuelin Zhang (215525), Qian Zhang (49333)   +2 more
core   +1 more source

PAD4 and von Willebrand Factor Link Inflammation and Thrombosis [PDF]

Circulation Research, 2019
Craig N, Morrell, Zachary T, Hilt, Daphne N, Pariser, Preeti, Maurya   +3 more
openaire   +2 more sources

PAD4

Seibutsu Butsuri, 2008
openaire   +3 more sources

Novel Macrocyclic Peptidylarginine Deiminase Type 4 (PAD4) Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2022
openaire   +2 more sources

PAD4 takes charge

Citrullination comprises the enzymatic modification of peptidylarginine to peptidylcitrulline by peptidyl arginine deiminase (PAD) enzymes. The role of citrullination in innate immunity has particularly sparked scientific interest after the finding that histone citrullination is involved in formation of neutrophil extracellular traps (NETs).
openaire   +2 more sources

Sepsis-induced NET formation requires MYD88 but is independent of GSDMD and PAD4.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Neutrophils are peripheral blood-circulating leukocytes that play a pivotal role in host defense against bacterial pathogens which upon activation, they release web-like chromatin structures called neutrophil extracellular traps (NETs). Here, we analyzed and compared the importance of myeloid differentiation factor 88 (MYD88), peptidyl arginine ...
Englert, Hanna, Rangaswamy, Chandini, Kullik, Giuliano A., Divivier, Mylène, Göbel, Josephine, Hermans‐Borgmeyer, Irm, Borgmeyer, Uwe, Mowen, Kerri A., Beerens, Manu, Frye, Maike, Mailer, Reiner K., Gelderblom, Mathias, Stavrou, Evi X., Preston, Roger J. S., Schneider, Stefan W., Fuchs, Tobias A., Renné, Thomas   +16 more
openaire   +2 more sources