Results 91 to 100 of about 7,025 (177)

Peptidylarginine deiminase 4-mediated citrullination in human disease: molecular mechanisms and therapeutic targeting. [PDF]

Front Pharmacol
Zou P, Su XD, Tian W, Xie XY, Yang K.
europepmc   +1 more source

Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4-Potentiating Activity in an Anti-Citrullinated Protein Antibody-Positive At-Risk Population. [PDF]

Scand J Immunol
Kaminska M, Joshua V, Bielecka E, Kantyka T, Chrobak M, Lundberg K, Hensvold A, Potempa J, Mydel P.   +8 more
europepmc   +1 more source

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis. [PDF]

MAbs
Sims GP, Scaletta L, Andrews J, Sims DA, Strain M, Sigurdardottir A, Kuriakose T, England E, Rajasinghe L, Jiang F, Xiong X, Neal F, Vinall L, Newton P, Boger E, Kim C, Dahlbäck H, Prothon S, Leander J, Darrah E, Collins M, Douglas G, White N, Day K, Vousden KA, Huntington CE, Close D.   +26 more
europepmc   +1 more source

Beyond PAD Inhibition: Emerging Avenues and Natural Products for Targeting Citrullination in Immune Diseases. [PDF]

Biomedicines
Chen Q, Ma Y, Liu Y, Wang X, Huang G, Yang Y, Ko JK, Chen H.   +7 more
europepmc   +1 more source

The unexpected localization of PAD4 in monocytes: implications for rheumatoid arthritis pathogenesis

Although anti-citrullinated protein autoantibodies (ACPAs) are a hallmark serological feature of rheumatoid arthritis (RA), the mechanisms and cellular sources behind the generation of the RA citrullinome remain incompletely defined.
Thomas, Mekha Ann
core   +1 more source

Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition. [PDF]

Biomolecules
Moon DO.
europepmc   +1 more source

Development Of Recombinant Peptides To Inhibit PAD4 Enzyme Involved in The Pathogenesis of Rheumatoıd Arthritis

Amaç: Romatoid artrit patogenezinden sorumlu peptidil arjinin deiminaz 4 enziminin aktivitesini azaltmaya yönelik değişken ağır zincir (VH; variable heavy chain) yapıda rekombinant inhibitor geliştirmektir. Gereç ve Yöntem: PAD4 geninin E.
Doğan, Yunus
core  

Roles of peptidylarginine deiminase (PAD) and protein citrullination in viral infections. [PDF]

Front Microbiol
Wang K, Ma T, Ouyang M, Fei X, Yang L, Guo G.   +5 more
europepmc   +1 more source

Targeting Peptidylarginine Deiminases in Neurons and Astrocytes in Central Nervous System Injury-Effects of Pan-PAD Inhibitor Cl-Amidine in an Oxygen-Glucose Deprivation Model of Ischaemia (OGD/R) and LPS Stimulation In Vitro. [PDF]

Int J Mol Sci
Ahmed D, Getting SJ, Ashioti M, Lange S.
europepmc   +1 more source

Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease. [PDF]

PLoS One
Gaál Kovalčíková A, Forraiová G, Korotushak N, Borbélyová V, Vavrincová-Yaghi D, Vavrinec P, Podracká Ľ, Celec P.   +7 more
europepmc   +1 more source