Results 91 to 100 of about 6,359 (194)

ERF transcription factor StPti5 is a regulator of endophyte community maintenance in potato

New Phytologist, Volume 251, Issue 3, Page 1344-1360, August 2026.
Summary We have recently identified an ethylene response factor, StPti5, as a susceptibility factor that negatively regulates immune responses to diverse pathogens. Here, we investigated the role of StPti5 in the processes involved in the colonization of potato with beneficial organisms.
Tjaša Lukan, Karmen Pogačar, Barbara Kraigher, Katja Stare, Teja Grubar Kovačič, Maja Zagorščak, Marko Petek, Polonca Stefanic, Anže Vozelj, Valentina Levak, Tjaša Mahkovec Povalej, Juan M. García, Maria J. Pozo, Eva Álvarez, José M. Franco‐Zorrilla, Maja Križnik, Špela Baebler, Ines Mandić‐Mulec, Kristina Gruden   +18 more
wiley   +1 more source

Reversing the Warburg Effect: YW3-56 Induces Leukemia Differentiation via AKT-Mediated Glucose Metabolic Reprogramming

Pharmaceuticals
Background: Protein arginine deiminase 4 (PAD4) has emerged as a promising therapeutic target for acute promyelocytic leukemia (APL) because of its role in epigenetic regulation and leukemogenesis.
Di Zhu, Dan Gao, Yu Lu, Na Chen, Li Zhang, Lan Zhang, Yuji Wang   +6 more
doaj   +1 more source

Chemical treatment rescues reduced growth of the autoimmune mutant chs3‐2D without compromising its immune responses

Plant Biology, Volume 28, Issue 5, Page 1686-1697, August 2026.
We generated a compound by chemical modification that can efficiently rescue growth without decreasing the immune response of the chs3‐2D autoimmune mutants, thus chemically uncoupling its growth–defence trade‐off. Abstract Plant development in many species including Arabidopsis relies on the accurate balance between growth and defence.
M. Keijzer, M. Liebers, J. Seufer, L. Voll, C. Meier, S. Hoth   +5 more
wiley   +1 more source

Regulation of E2F1 by PAD4 mediated citrullination

, 2015
Peptidyl arginine deiminase (PAD) 4 is a nuclear enzyme that converts arginine residues to citrulline. PAD4 activity has been implicated in inflammatory disease and cancer, although its mechanism of action, particularly the identity of functionally relevant targets, remains unclear.
openaire   +2 more sources

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Nature Communications
Peptidylarginine deiminases (PAD1-4) are calcium dependent enzymes responsible for protein citrullination, a post-translational modification converting arginine residues to citrulline.
Leslie A. Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F. Vajdos, Jeffrey W. Pelker, Simeon Ramsey, Paul Balbo, Parag V. Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W. Wright, Jeanne S. Chang, John M. Curto, Jennifer E. Davoren, Susan E. Drozda, Kimberly F. Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L. Lee, Shenping Liu, Frank Lovering, Jennifer A. Nicki, John I. Trujillo, Fabien Vincent, Mark E. Schnute   +25 more
doaj   +1 more source

PAD4

Seibutsu Butsuri, 2008
openaire   +3 more sources

Mapping the Substrate Specificity Landscape of PAD2 and PAD4 Enzymes. [PDF]

Chembiochem
Borbély A, Steckel A, Papp D, Pál D, Uray K, Gőz VG, Schlosser G.   +6 more
europepmc   +1 more source

Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4-Potentiating Activity in an Anti-Citrullinated Protein Antibody-Positive At-Risk Population. [PDF]

Scand J Immunol
Kaminska M, Joshua V, Bielecka E, Kantyka T, Chrobak M, Lundberg K, Hensvold A, Potempa J, Mydel P.   +8 more
europepmc   +1 more source

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis. [PDF]

MAbs
Sims GP, Scaletta L, Andrews J, Sims DA, Strain M, Sigurdardottir A, Kuriakose T, England E, Rajasinghe L, Jiang F, Xiong X, Neal F, Vinall L, Newton P, Boger E, Kim C, Dahlbäck H, Prothon S, Leander J, Darrah E, Collins M, Douglas G, White N, Day K, Vousden KA, Huntington CE, Close D.   +26 more
europepmc   +1 more source

DNA From Neutrophil Extracellular Traps Restricts Group 3 Innate Lymphoid Cells Function in Intestinal Epithelial Repair via CCDC25. [PDF]

FASEB J
Xu B, Ke X, Xie X, Yi Q, Li C, Zhao M, Deng X, Wang Q, Chen H, Xu R, Cao S, Zhu Y, Zhou L, Wang Q, Luo X.   +14 more
europepmc   +1 more source