Results 101 to 110 of about 9,594 (224)

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, Volume 4, Issue 3, September 2026.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease

International Journal of COPD, 2018
David Hutchinson,1,2 Judith Müller,3 Joseph E McCarthy,4 Yurii K Gun’ko,4,5 Navin Kumar Verma,6 Xuezhi Bi,7 Luisana Di Cristo,8 Laura Kickham,8 Dania Movia,8 Adriele Prina-Mello,5,8 Yuri Volkov5,8,9 1Royal Cornwall Hospital NHS Trust ...
Hutchinson D, Müller J, McCarthy JE, Gun'ko YK, Verma NK, Bi X, Di Cristo L, Kickham L, Movia D, Prina-Mello A, Volkov Y   +10 more
doaj  

B Lymphocytes in Latent Autoimmune Diabetes in Adults: From Autoimmune Activation to Immunometabolic Heterogeneity and Precision Therapeutic Perspectives

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Latent autoimmune diabetes in adults (LADA) is a heterogeneous form of autoimmune diabetes characterised by adult onset, the presence of islet autoantibodies, and a slower progression to insulin dependence compared with classical type 1 diabetes.
Moncef Zouali
wiley   +1 more source

ACPAs Are Much More Than Diagnostic Autoantibodies

Rambam Maimonides Medical Journal, 2016
Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and ...
Abdulla Watad, Howard Amital
doaj   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Citrullination Inactivates Nicotinamide‑N‑methyltransferase

, 2018
Nicotinamide-N-methyl­transferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide using S-adenosyl methionine as a methyl donor. NNMT is implicated in several chronic disease conditions, including cancers,
Eranthie Weerapana (1377093), Ronak Tilvawala (1453684), Son Hong Nguyen, Lacey Miller, Ari J. Salinger, Son Hong Nguyen (1958257), Eranthie Weerapana, Venkatesh V. Nemmara (1969867), Venkatesh V. Nemmara, Ronak Tilvawala, Paul R. Thompson (105487), Lacey Miller (5614409), Paul R. Thompson, Ari J. Salinger (2910698)   +13 more
core   +1 more source

SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination

Cell Reports, 2017
Histone citrullination regulates diverse cellular processes. Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post ...
Shu Xiao, Jia Lu, Bharat Sridhar, Xiaoyi Cao, Pengfei Yu, Tianyi Zhao, Chieh-Chun Chen, Darina McDee, Laura Sloofman, Yang Wang, Marcelo Rivas-Astroza, Bhanu Prakash V.L. Telugu, Dana Levasseur, Kang Zhang, Han Liang, Jing Crystal Zhao, Tetsuya S. Tanaka, Gary Stormo, Sheng Zhong   +18 more
doaj   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Potential role for PADI-mediated histone citrullination in preimplantation development [PDF]

, 2012
Background: The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process that is known as citrullination or deimination. Previous reports have documented roles for
Mei Jin, Thompson, Paul R., Rui Kan, Venkataraman Subramanian, Subramanian, Venkataraman, Corey P Causey, Paul R Thompson, Jin, Mei, Scott A Coonrod, Coonrod, Scott A., Kan, Rui, Causey, Corey P.   +11 more
core   +1 more source

GnRH Induces Citrullination of the Cytoskeleton in Murine Gonadotrope Cells [PDF]

Peptidylarginine deiminases (PADs or PADIs) catalyze the conversion of positively charged arginine to neutral citrulline, which alters target protein structure and function. Our previous work established that gonadotropin-releasing hormone agonist (GnRHa)
Geisterfer, Zachary M., Thompson, Paul R., DeVore, Stanley B., Amy M. Navratil, Quigley, Elizabeth B., Khan, Shaihla A., Elizabeth B. Quigley, Rothfuss, Heather M., Jesse C. Gatlin, Brian D. Cherrington, Shaihla A. Khan, Stanley B. DeVore, Sequoia, Ari O., Gatlin, Jesse C., Navratil, Amy M., Paul R. Thompson, Cherrington, Brian D., Zachary M. Geisterfer, Ari O. Sequoia, Heather M. Rothfuss   +19 more
core   +2 more sources