Results 111 to 120 of about 1,964 (177)

Molecular Quantification of Fibrogenesis and Macrophage Activation Associate With Clinical Worsening in Patients With Cirrhosis

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Knowledge of the potential of biomarkers for monitoring clinical improvement, assessing trajectory or disease progression in advanced chronic liver disease is still insufficient. This study investigated biomarkers of fibrosis and macrophage activation over time in newly diagnosed patients with cirrhosis and their potential association with ...
Emilie Toft Skovgaard, Jens Peter Goetze, Thit Mynster Kronborg, Søren Møller, Henning Grønbæk, Holger Jon Møller, Morten Karsdal, Diana Julie Leeming, Nina Kimer   +8 more
wiley   +1 more source

Beyond PAD Inhibition: Emerging Avenues and Natural Products for Targeting Citrullination in Immune Diseases

Biomedicines
Immune-mediated inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus, impose a severe and growing global health burden, where current therapies are limited by poor specificity and significant side ...
Qilei Chen, Yuhang Ma, Yingyi Liu, Xiaojie Wang, Guanhua Huang, Yizhao Yang, Joshua Ka-Shun Ko, Hubiao Chen   +7 more
doaj   +1 more source

The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy

MedComm, Volume 7, Issue 6, June 2026.
Neutrophils secrete cytokines, express specific surface proteins, increase or decrease in cell count, and their ratio to lymphocyte count can be used as biomarkers to characterize collective status and disease progression. Neutrophils can monitor and track the body's health status, “Wei Bing” status, disease status, and different times of disease ...
Zhen Ma, Qing Wang, Yusheng Zhang, Yang Li, Hongwei Wu, Hongjun Yang, Xianyu Li   +6 more
wiley   +1 more source

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Investigating PAD-mediated citrullination in HPV-driven head and neck squamous cell carcinoma

Citrullination is a post-translational modification catalyzed by peptidyl-arginine deiminases (PADs), which convert peptidyl-arginine into peptidyl-citrulline.
Linda Trifirò, Matteo Biolatti, Camilla Albano, Giulia Orlando, Rebecca Senetta, Selina Pasquero, Valentina Dell’Oste, Francesca Gugliesi, Greta Bajetto, Giuseppe Riva, Marco Briguglio, Giancarlo Pecorari, Marco De Andrea   +12 more
core  

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Neuroendocrine tumours through an epigenetic lens: Emerging insights for diagnosis and treatment

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Neuroendocrine tumours (NETs) are well‐differentiated epithelial neuroendocrine neoplasms that frequently develop in the small intestine, pancreas, and lungs. NETs originate from neuroendocrine cells specialized in hormone secretion implicated in a number of physiological processes.
Victoria Jacquot, Benjamin Chevalier, Thomas Walter, Benjamin Gibert, Maria Ouzounova   +4 more
wiley   +1 more source

Non‐HLA Autoantibodies Associate With a Positive Flow‐Crossmatch Pre‐ and Chronic Lung Allograft Dysfunction Post‐ Lung Transplant

HLA, Volume 107, Issue 6, June 2026.
ABSTRACT Antibodies to HLA are a major cause of chronic lung allograft dysfunction (CLAD) following lung transplantation (LTx), however mounting evidence indicates non‐HLA autoantibodies may also play a role. LTx recipients may have increased autoantibodies related to their native disease, and these may impact both pre‐transplant assays and LTx ...
Steven Hiho, Alex Paporakis, Sadiaa Rahman, Bronwyn Levvey, Mary Diviney, Gregory Snell, Lucy Sullivan, Glen Westall   +7 more
wiley   +1 more source

Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin‐Like Lasso Peptide

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
Biosynthesis of the class V lasso peptide gelatinamin A was elucidated by heterologous expression of the gel biosynthetic gene cluster in Bacillus subtilis. Its 3D structure was determined by NMR, and tailoring enzymes GelT and GelP were fully reconstituted in vitro.
Tiziana Svenningsen, Aske Merrild, Fang Wang, Frederikke D. Hansen, Toby G. Johnson, Reina Iwase, Thibault Viennet, Morten K. Larsen, A. James Link, Thomas Tørring   +9 more
wiley   +1 more source

Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response

iScience
Summary: SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replication and inflammation.
Selina Pasquero, Alessandro Penna, Lucia Signorini, Salvatore Villani, Francesca Gugliesi, Valeria Caneparo, Francesco Favero, Webb Camille, Robert M. Green, Ilaria Frasson, Anna Tosi, Beatrice Genova, Anna Dalla Pietà, Ranieri Verin, Sofia Tomasoni, Erika Del Grosso, Serena Delbue, Sara N. Richter, Paul R. Thompson, Antonio Rosato, Marco De Andrea   +20 more
doaj   +1 more source