Results 111 to 120 of about 9,594 (224)

Immunomodulatory Nanozymes as Programmable Redox–Immune Set‐Point Regulators

Small, Volume 22, Issue 53, 21 September 2026.
Conceptual phase space linking reactive oxygen species level/dynamics to immune state, with pathological set‐points for chronic inflammation, tumor escape, and degeneration contrasted against a central healthy redox–immune set‐point. Buffering and amplifying nanozymes are depicted as devices that dial redox tone up or down to steer diseased ...
Sumi Choi, Minjeong Kim, Sang Jin Lee, Su‐Hwan Kim   +3 more
wiley   +1 more source

Exploring Neutrophil Extracellular Traps in Canine Soft Tissue Sarcomas: A Preliminary Study With Translational Insights

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Neutrophil Extracellular Traps (NETs) in Canine Soft Tissue Sarcomas This study investigated the presence of neutrophil extracellular traps (NETs) in canine soft tissue sarcomas using dual immunohistochemistry for citrullinated histone‐3 and myeloperoxidase.
Burak Yildirim, Volkan Ipek
wiley   +1 more source

Protective and Pathogenic Antibodies to Citrullinated Antigens

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila, Yibo He, Zhongwei Xu, Changrong Ge, Erik Lönnblom, Rikard Holmdahl   +5 more
wiley   +1 more source

Complement Activation by Post‐Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek, Leendert A. Trouw   +1 more
wiley   +1 more source

Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT In this study, we tested the hypothesis that there is an interaction between neutrophils (N) undergoing NETosis and the activation of macrophages (Mf) in the myocardium of patients with heart failure (HF). Ventricular biopsies were examined from patients with HF due to dilated (DCM, n = 7), ischemic (ICM, n = 7), or inflammatory (InfCM, n = 7)
Sawa Kostin, Hector A. Cabrera‐Fuentes, Manfred Richter, Florian Krizanic, Oliver Ritter, William A. Boisvert, Klaus T. Preissner, Theodoros Kelesidis, Gerasimos Siasos, Nikolaos Pagonas   +9 more
wiley   +1 more source

Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response

iScience
Summary: SARS-CoV-2, the causative agent of COVID-19, remains a global concern due to gaps in understanding its pathogenesis. Peptidyl-arginine deiminases (PADs) are emerging as key regulators of viral replication and inflammation.
Selina Pasquero, Alessandro Penna, Lucia Signorini, Salvatore Villani, Francesca Gugliesi, Valeria Caneparo, Francesco Favero, Webb Camille, Robert M. Green, Ilaria Frasson, Anna Tosi, Beatrice Genova, Anna Dalla Pietà, Ranieri Verin, Sofia Tomasoni, Erika Del Grosso, Serena Delbue, Sara N. Richter, Paul R. Thompson, Antonio Rosato, Marco De Andrea   +20 more
doaj   +1 more source

PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer

Frontiers in Cellular and Infection Microbiology
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple
Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Greta Bajetto, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Marco De Andrea, Valentina Dell’Oste   +17 more
doaj   +1 more source

Impact of increased Porphyromonas gingivalis peptidylarginine deiminase (PPAD) T2 variant allele on oral microbiota composition and severity of chronic periodontitis

Journal of Oral Microbiology
Background Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, encoding a unique peptidyl arginine deiminase (PPAD) linked to protein citrullination, a process associated with rheumatoid arthritis (RA).
Marta Kaminska, Noemie A.M. Dudzinska, Tülay Yucel-Lindberg, Birgitta Söder, Aswathy Narayanan, Jan Potempa, Piotr M. Mydel   +6 more
doaj   +1 more source

Citrulline [PDF]

, 2020
openaire   +1 more source

l-(+)Citrulline [PDF]

Biochemical Journal, 1939
A G, Gornall, A, Hunter
openaire   +2 more sources