Results 121 to 130 of about 1,964 (177)

Potential role for PADI-mediated histone citrullination in preimplantation development.

, 2015
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.BACKGROUND: The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process
Subramanian, Venkataraman, Thompson, Paul R, Jin, Mei, Coonrod, Scott A., Kan, Rui, Causey, Corey P.   +5 more
core   +1 more source

Potential role for PADI-mediated histone citrullination in preimplantation development

, 2012
Background: The peptidylarginine deiminases (PADIs) convert positively charged arginine residues to neutrally charged citrulline on protein substrates in a process that is known as citrullination or deimination. Previous reports have documented roles for
Mei Jin, Thompson, Paul R., Rui Kan, Venkataraman Subramanian, Subramanian, Venkataraman, Corey P Causey, Paul R Thompson, Jin, Mei, Scott A Coonrod, Coonrod, Scott A., Kan, Rui, Causey, Corey P.   +11 more
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PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer

Frontiers in Cellular and Infection Microbiology
Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple
Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Greta Bajetto, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Marco De Andrea, Valentina Dell’Oste   +17 more
doaj   +1 more source

Citrullination in tumor immunity and therapy

Journal of Clinical Investigation
Peptidyl arginine deiminases (PADs) catalyze the conversion of arginine residues into peptidyl citrulline, a posttranslational modification known as protein citrullination (or arginine deimination). This process alters the charge of proteins from positive to neutral, thereby affecting their folding, stability, conformation, and function.
Pitter, Michael R., Zou, Weiping
openaire   +2 more sources

Impact of increased Porphyromonas gingivalis peptidylarginine deiminase (PPAD) T2 variant allele on oral microbiota composition and severity of chronic periodontitis

Journal of Oral Microbiology
Background Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, encoding a unique peptidyl arginine deiminase (PPAD) linked to protein citrullination, a process associated with rheumatoid arthritis (RA).
Marta Kaminska, Noemie A.M. Dudzinska, Tülay Yucel-Lindberg, Birgitta Söder, Aswathy Narayanan, Jan Potempa, Piotr M. Mydel   +6 more
doaj   +1 more source

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

, 2012
The aim of this study was to explore the presence and localization of myocardial citrullination in samples from rheumatoid arthritis (RA) patients compared to rheumatic and non-rheumatic disease control groups. Archived myocardial samples obtained during
Rosen, Antony, Pappas, Dimitrios, Park, Jin Kyun, Fox-Talbot, Karen, Andrade, Felipe, Giles, Jon T., Halushka, Mark C., van Eyk, Jennifer, Bathon, Joan M., Fert-Bober, Justyna, Bingham, Clifton O.   +10 more
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Abstract 1102: Regulation of protein citrullination through p53/PADI4 network in DNA damage response

, 2010
Upon wide range of cellular stresses, p53 is activated and inhibits malignant transformation through the transcriptional regulation of its target genes related to apoptosis, cell cycle arrest, and DNA repair. However its involvement in post-translational
Yusuke Nakamura, Chizu Tanikawa, Koichi Matsuda   +2 more
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l-(+)Citrulline [PDF]

Biochemical Journal, 1939
A G, Gornall, A, Hunter
openaire   +2 more sources

Citrullination of the matrix: a potential link to age related changes in bone tissue [PDF]

, 2019
There is a strong correlation between aging and risk of fractures that is independent of changes in bone quantity. Although the underlying processes that dysregulate the structural health and integrity of bone tissue without affecting bone-quantity with ...
Sontha, Sainikhil
core  

Citrulline [PDF]

, 2020
openaire   +1 more source