Results 141 to 150 of about 1,964 (177)
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Current Opinion in Clinical Nutrition and Metabolic Care, 2007
Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these
Emmanuel, Curis +2 more
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Citrulline, a nonprotein amino acid, is an important source of endogenous arginine. The gut is the main source of citrulline in humans. Hence, citrulline is a potential biomarker of short bowel function. Conversely, citrulline uptake by the gut is important for an oral supply of this amino acid as an alternative to arginine. This review discusses these
Emmanuel, Curis +2 more
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Citrulline utilization in Crithidia
Biochemical and Biophysical Research Communications, 1966It was early noted in growth studies (Kidder and Dutta, 1958) that the trypanosomid flagellate Crithidia fasciculata could utilize citrulline, but not ornithine, as a replacement for arginine . A somewhat more efficient use of citrulline than arginine suggested that citrulline might be contributing directly to reactions other than just the production ...
G W, Kidder, J S, Davis, K, Cousens
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Metabolism of citrulline in man
Amino Acids, 1995Citrulline is a non protein amino acid involved in three important metabolic pathways, the intrahepatic transformation of ammonia to urea, the de novo synthesis of arginine from glutamine in gut and kidney, the nitric oxide synthesis. The two first pathways use the same enzyme activities but are regulated in different way.
D, Rabier, P, Kamoun
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Citrulline metabolism in plants
Amino Acids, 2017Citrulline was chemically isolated more than 100 years ago and is ubiquitous in animals, plants, bacteria, and fungi. Most of the research on plant citrulline metabolism and transport has been carried out in Arabidopsis thaliana and the Cucurbitaceae family, particularly in watermelon which accumulates this non-proteinogenic amino acid to very high ...
Vijay Joshi, Alisdair R. Fernie
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Analytical Biochemistry, 2012
Citrulline, a key amino acid of the urea cycle, has been shown to play a regulatory role in protein and energy metabolism in mammals. We questioned whether N-carbamoyl-putrescine (NCP), the decarboxylated derivative of citrulline, could play a role in the biological properties of this amino acid. To evidence the presence of NCP in mammalian tissues, we
D, Ramani +6 more
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Citrulline, a key amino acid of the urea cycle, has been shown to play a regulatory role in protein and energy metabolism in mammals. We questioned whether N-carbamoyl-putrescine (NCP), the decarboxylated derivative of citrulline, could play a role in the biological properties of this amino acid. To evidence the presence of NCP in mammalian tissues, we
D, Ramani +6 more
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Citrullinated proteins in rheumatoid arthritis
Frontiers in Bioscience, 2005Citrullinated proteins that are produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases (PADIs) are of particular interest in the pathogenesis of rheumatoid arthritis (RA). First, peptidylarginine deiminase type 4 (PADI4) gene, which codes one of the PADI enzyme isotypes, has a genetic variant that increases ...
Ryo, Yamada +3 more
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Citrulline synthesis in rat tissues
Archives of Biochemistry and Biophysics, 1961Abstract The distribution of carbamyl phosphate synthetase (CPS) and/or ornithine transcarbamylase (OTC) was determined in 17 different rat tissues. Both enzymes, but particularly OTC, were found to be located mainly in the liver so that assay for OTC activity can provide a highly specific test for liver parenchymal cells.
M E, JONES +3 more
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The presence of citrulline in epidermal proteins
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1979Citrulline is present in the stratum corneum proteins of human, cow snout, pig snout and guinea pig epidermis but is absent from the stratum corneum proteins of frog, mouse, turtle, rat and hamster epidermis. The amino acid is released by acid hydrolysis and ranges from 1.7 to 5.5 residues per thousand residues of protein amino acid.
J, Kubilus, R W, Waitkus, H P, Baden
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Citrullinated proteins in Rheumatoid Arthritis
Reumatología Clínica (English Edition), 2011Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in ...
Elizabeth, Olivares Martínez +3 more
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Citrulline: A potential immunomodulator in sepsis
Surgery, 2011Sepsis leads to a complex systemic response of cytokines (both pro- and anti-inflammatory) and more recently recognized adipokine mediators. Endothelial nitric oxide (NO) may be a key component in regulating this response, but the pharmacologic manipulation of endothelial NO via L-arginine supplementation or inhibitors has provided inconsistent ...
Theodor, Asgeirsson +7 more
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