Results 21 to 30 of about 7,469 (193)

Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis

Cells, 2020
Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated
Ji Soo Kim, Mikyung Choi, Ji Yong Choi, Joo Yeon Kim, Jeong Yeon Kim, Jin-Su Song, Lionel B. Ivashkiv, Eun Young Lee   +7 more
doaj   +1 more source

A Hairy Cituation – PADIs in Regeneration and Alopecia

Frontiers in Cell and Developmental Biology, 2021
In this Review article, we focus on delineating the expression and function of Peptidyl Arginine Delminases (PADIs) in the hair follicle stem cell lineage and in inflammatory alopecia. We outline our current understanding of cellular processes influenced
Kim Vikhe Patil, Kylie Hin-Man Mak, Maria Genander   +2 more
doaj   +1 more source

Protein citrullination: A proposed mechanism for pathology in traumatic brain injury

Frontiers in Neurology, 2015
Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer’s disease, multiple sclerosis (MS) and prion disease.
Rachel C Lazarus, John E Buonora, Michael N Flora, James G Freedy, Gay R Holstein, Giorgio P Martinelli, David M Jacobowitz, David M Jacobowitz, Gregory P Mueller, Gregory P Mueller, Gregory P Mueller   +10 more
doaj   +1 more source

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
doaj   +1 more source

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination

Molecular & Cellular Oncology, 2021
Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in
Sébastien Coassolo, Irwin Davidson
doaj   +1 more source

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

Frontiers in Immunology, 2012
NETosis, the process wherein neutrophils release highly decondensed chromatin called neutrophil extracellular traps (NETs), has gained much attention as an alternative means of killing bacteria.
Marc eLeshner, Shu eWang, Carrie eLewis, Han eZheng, Xiangyun Amy Chen, Lorraine eSanty, Yanming eWang   +6 more
doaj   +1 more source

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

Frontiers in Immunology, 2021
Citrullination, the conversion of peptidyl-arginine into peptidyl-citrulline, is involved in the breakage of self-tolerance in anti-CCP-positive rheumatoid arthritis.
María Teresa Martín Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Šenolt, Niels Ødum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Claus H. Nielsen, Dres Damgaard   +10 more
doaj   +1 more source

Biosynthesis of Citrulline in Plants [PDF]

Nature, 1961
IN 1930 citrulline was discovered in water-melons1. Later it was shown to be an important participant in the Krebs and Henseleit ornithine cycle in animals and micro-organisms. In recent years several laboratories have worked on the ornithine cycle in plants.
openaire   +2 more sources

Detection and quantification of citrullinated chemokines. [PDF]

PLoS ONE, 2011
BackgroundPosttranslational deimination or citrullination by peptidylarginine deiminases (PAD) regulates the biological function of proteins and may be involved in the development of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Eva A V Moelants, Jo Van Damme, Paul Proost   +2 more
doaj   +1 more source

Implications of Porphyromonas gingivalis peptidyl arginine deiminase and gingipain R in human health and diseases

Frontiers in Cellular and Infection Microbiology, 2022
Porphyromonas gingivalis is a major pathogenic bacterium involved in the pathogenesis of periodontitis. Citrullination has been reported as the underlying mechanism of the pathogenesis, which relies on the interplay between two virulence factors of the ...
Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong, Sheri-Ann Tan   +8 more
doaj   +1 more source