Results 21 to 30 of about 9,594 (224)

Rheumatoid arthritis and citrullination [PDF]

Current Opinion in Rheumatology, 2018
Purpose of reviewDysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA.Recent findingsThe study of synovial fluid from patients with RA has provided ...
Erika, Darrah, Felipe, Andrade
openaire   +2 more sources

Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model. [PDF]

, 2014
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation followed by tissue rebuilding or fibrosis. A failure by the body to regulate inflammation effectively is one of the hallmarks of RA.
Saralili Dipa Robertson, Nidhi eSofat, Robertson, Saralili D, Baines, DL, Wait, R, Robertson, SD, Wait, Robin, Robin eWait, Emma Harriet Baker, Baines, Deborah L, Deborah eBaines, Deborah L. Baines, Sofat, N, Baker, EH, Nidhi Sofat, Saralili D. Robertson, Emma H. Baker, Sofat, Nidhi, Baker, Emma H, Robin Wait   +19 more
core   +1 more source

Autophagy, citrullination and cancer [PDF]

Autophagy, 2016
A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant, Rachael L, Metheringham, Victoria A, Brentville   +2 more
openaire   +2 more sources

Citrullination: new tricks for an old mod

, 2023
International audienceProteins are subject to a myriad of chemical modifications that modulate their structure, stability, function and interaction with other molecules, adding an enormous amount of complexity and scope for regulation to biological ...
Christophorou, Maria, A, Sharma, Priyanka, Zhang, Xuesen   +2 more
core   +1 more source

Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis

Cells, 2020
Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated
Ji Soo Kim, Mikyung Choi, Ji Yong Choi, Joo Yeon Kim, Jeong Yeon Kim, Jin-Su Song, Lionel B. Ivashkiv, Eun Young Lee   +7 more
doaj   +1 more source

Human cytomegalovirus-induced host protein citrullination is crucial for viral replication

Nature Communications, 2021
Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in ...
Gloria Griffante, Francesca Gugliesi, Selina Pasquero, Valentina Dell’Oste, Matteo Biolatti, Ari J. Salinger, Santanu Mondal, Paul R. Thompson, Eranthie Weerapana, Robert J. Lebbink, Jasper A. Soppe, Thomas Stamminger, Virginie Girault, Andreas Pichlmair, Gábor Oroszlán, Donald M. Coen, Marco De Andrea, Santo Landolfo   +17 more
doaj   +1 more source

A Hairy Cituation – PADIs in Regeneration and Alopecia

Frontiers in Cell and Developmental Biology, 2021
In this Review article, we focus on delineating the expression and function of Peptidyl Arginine Delminases (PADIs) in the hair follicle stem cell lineage and in inflammatory alopecia. We outline our current understanding of cellular processes influenced
Kim Vikhe Patil, Kylie Hin-Man Mak, Maria Genander   +2 more
doaj   +1 more source

Protein citrullination: A proposed mechanism for pathology in traumatic brain injury

Frontiers in Neurology, 2015
Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer’s disease, multiple sclerosis (MS) and prion disease.
Rachel C Lazarus, John E Buonora, Michael N Flora, James G Freedy, Gay R Holstein, Giorgio P Martinelli, David M Jacobowitz, David M Jacobowitz, Gregory P Mueller, Gregory P Mueller, Gregory P Mueller   +10 more
doaj   +1 more source

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
doaj   +1 more source

Inflammation-related citrullination of matrisome proteins in human cancer [PDF]

, 2023
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Siljamäki Elina, Suwal Ujjwal, Rappu Pekka, Heino Jyrki   +3 more
core   +1 more source