Results 21 to 30 of about 1,964 (177)
The role of SERPIN citrullination in thrombosis
, 2022 Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in rheumatoid ...
Wagner, Denisa +9 more
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Autophagy, citrullination and cancer [PDF]
Autophagy, 2016 A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant +2 more
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Rheumatoid arthritis and citrullination [PDF]
Current Opinion in Rheumatology, 2018 Purpose of reviewDysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA.Recent findingsThe study of synovial fluid from patients with RA has provided ...
Erika, Darrah, Felipe, Andrade
openaire +2 more sources
Citrullination in Cancer [PDF]
Cancer Research, 2019 Abstract Posttranslational modifications of proteins have been implicated in pathogenesis of numerous diseases. Arginine deimination (also known as citrullination) has a principal role in progression of rheumatoid arthritis through generation of autoantibodies and exacerbation of the inflammatory response.
openaire +2 more sources
Cells, 2020 Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated
Ji Soo Kim +7 more
doaj +1 more source
Inflammation-related citrullination of matrisome proteins in human cancer [PDF]
, 2023 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Siljamäki Elina +3 more
core +1 more source
Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
Nature Communications, 2021 Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in ...
Gloria Griffante +17 more
doaj +1 more source
Citrullination: new tricks for an old mod
, 2023 International audienceProteins are subject to a myriad of chemical modifications that modulate their structure, stability, function and interaction with other molecules, adding an enormous amount of complexity and scope for regulation to biological ...
Christophorou, Maria, A +2 more
core +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
A Hairy Cituation – PADIs in Regeneration and Alopecia
Frontiers in Cell and Developmental Biology, 2021 In this Review article, we focus on delineating the expression and function of Peptidyl Arginine Delminases (PADIs) in the hair follicle stem cell lineage and in inflammatory alopecia. We outline our current understanding of cellular processes influenced
Kim Vikhe Patil +2 more
doaj +1 more source