Results 11 to 20 of about 1,964 (177)
Characterizing citrullination by mass spectrometry-based proteomics
Philosophical Transactions of the Royal Society B: Biological Sciences, 2023 Citrullination is an important post-translational modification (PTM) of arginine, known to play a role in autoimmune disorders, innate immunity response and maintenance of stem cell potency. However, citrullination remains poorly characterized and not as
Alexandra S Rębak +2 more
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Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis [PDF]
Respiratory Research, 2017 Background Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity ...
Katerina D. Samara +12 more
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Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination
Molecular & Cellular Oncology, 2021 Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in
Sébastien Coassolo, Irwin Davidson
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PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination [PDF]
Cell Reports, 2019 Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination ...
Ana Mendanha Falcao +2 more
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Nature Communications, 2018 Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of ...
A. E. Yuzhalin +13 more
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The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases
Journal of Innate Immunity, 2022 Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically,
Martin Maronek, Roman Gardlik
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Inflammation-related citrullination of matrisome proteins in human cancer
Frontiers in Oncology, 2022 IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu +3 more
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Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination
Journal of Immunology Research, 2021 The aberrant upregulation of protein arginine deiminase 2- (PAD2-) catalyzed citrullination is reported in various autoimmune diseases (rheumatoid arthritis and multiple sclerosis) and several cancers.
Masayoshi Aosasa +8 more
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Diagnostics, 2023 The present review aims to describe the state of the art of research studies investigating the citrullination post-translational modification in adult and pediatric brain tumors.
Diana Valeria Rossetti +4 more
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Frontiers in Immunology, 2023 IntroductionPeptidylarginine deiminases (PADs) mediate citrullination, an irreversible posttranslational modification that converts arginine to citrulline residues in proteins.
Karen Yu +11 more
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