Results 11 to 20 of about 7,469 (193)
Diagnostics, 2023 The present review aims to describe the state of the art of research studies investigating the citrullination post-translational modification in adult and pediatric brain tumors.
Diana Valeria Rossetti +4 more
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Citrullination and Autophagy [PDF]
, 2017 During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.
Guido Valesini +5 more
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Frontiers in Immunology, 2023 IntroductionPeptidylarginine deiminases (PADs) mediate citrullination, an irreversible posttranslational modification that converts arginine to citrulline residues in proteins.
Karen Yu +11 more
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Autophagy, citrullination and cancer [PDF]
Autophagy, 2016 A cell needs to maintain a balance between biosynthesis and degradation of cellular components to maintain homeostasis. There are 2 pathways, the proteasome, which degrades short-lived proteins, and the autophagy/lysosomal pathway, which degrades long-lived proteins and organelles. Both of these pathways are also involved in antigen presentation or the
Lindy G, Durrant +2 more
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Progression on Citrullination of Proteins in Gastrointestinal Cancers
Frontiers in Oncology, 2019 The citrullination modification (Cit) of proteins has received increasing attention in recent years. This kind of protein modification was first discovered in autoimmune diseases such as rheumatoid arthritis.
Shuzheng Song, Yingyan Yu
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Rheumatoid arthritis and citrullination [PDF]
Current Opinion in Rheumatology, 2018 Purpose of reviewDysregulated citrullination is a key element that drives the production and maintenance of antibodies to citrullinated proteins, a hallmark in rheumatoid arthritis (RA). This article reviews recent literature on the origin of citrullinated antigens in RA.Recent findingsThe study of synovial fluid from patients with RA has provided ...
Erika, Darrah, Felipe, Andrade
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Frontiers in Immunology, 2020 Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova +9 more
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Human cytomegalovirus-induced host protein citrullination is crucial for viral replication
Nature Communications, 2021 Citrullination is a posttranslational modification of arginines. Here, the authors show that HCMV infection increases citrullination of host and virus proteins to promote infection and that citrullinated interferon-inducible protein IFIT1 is impaired in ...
Gloria Griffante +17 more
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Citrullination in Cancer [PDF]
Cancer Research, 2019 Abstract Posttranslational modifications of proteins have been implicated in pathogenesis of numerous diseases. Arginine deimination (also known as citrullination) has a principal role in progression of rheumatoid arthritis through generation of autoantibodies and exacerbation of the inflammatory response.
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