Results 11 to 20 of about 9,594 (224)

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection [PDF]

Frontiers in Immunology, 2020
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Víctor Casanova, Filipa Henderson Sousa, Priyanka Shakamuri, Pavel Svoboda, Chloé Buch, Mathilde D'Acremont, Maria A. Christophorou, Jan Pohl, Craig Stevens, Peter G. Barlow   +9 more
doaj   +2 more sources

Citrullination and Autophagy [PDF]

, 2017
During evolution, the eukaryotic cells develop different processes in order to adapt themselves to environmental changes, as well as to die or to survive. These processes include apoptosis, NETosis, and autophagy: citrullination is implicated in all of these physiological mechanisms.
Guido Valesini, Tania Colasanti, Cristiano Alessandri, Michele Bombardieri, Fabrizio Conti, Maurizio Sorice   +5 more
openaire   +3 more sources

Joint inflammation related citrullination of functional arginines in extracellular proteins [PDF]

Scientific Reports, 2017
We report the extent, specific sites and structural requirements of joint inflammation related citrullination in extracellular proteins. A total of 40 synovial fluid samples derived from chronically inflamed human joints were analysed by heparin-agarose ...
Kalle H. Sipilä, Vipin Ranga, Pekka Rappu, Markku Mali, Laura Pirilä, Ilona Heino, Johanna Jokinen, Jarmo Käpylä, Mark S. Johnson, Jyrki Heino   +9 more
doaj   +3 more sources

Regulation of glycolysis and cancer cell proliferation by PKM2 citrullination

Molecular & Cellular Oncology, 2021
Conversion of peptidyl-arginine to peptidyl citrulline, known as citrullination, is a post-translational protein modification catalyzed by the PADI (Protein Arginine Deiminase) family of enzymes. PADI1 and PADI3 catalyze citrullination of arginine 106 in
Sébastien Coassolo, Irwin Davidson
doaj   +2 more sources

Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis [PDF]

Respiratory Research, 2017
Background Increased protein citrullination and peptidylarginine deiminases (PADIs), which catalyze the citrullination process, are central in Rheumatoid arthritis pathogenesis and probably involved in the initial steps towards autoimmunity ...
Katerina D. Samara, Athina Trachalaki, Eliza Tsitoura, Anastasios V. Koutsopoulos, Eleni D. Lagoudaki, Ismini Lasithiotaki, George Margaritopoulos, Panagiotis Pantelidis, Eleni Bibaki, Nikolaos M. Siafakas, Nikolaos Tzanakis, Athol U. Wells, Katerina M. Antoniou   +12 more
doaj   +2 more sources

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix [PDF]

Nature Communications, 2018
Colorectal cancers (CRCs) often develop into untreatable metastatic disease of the liver. Here the authors report the modification of extracellular matrix proteins by citrullination in CRC metastases to the liver and propose that inhibition of ...
A. E. Yuzhalin, A. N. Gordon-Weeks, M. L. Tognoli, K. Jones, B. Markelc, R. Konietzny, R. Fischer, A. Muth, E. O’Neill, P. R. Thompson, P. J. Venables, B. M. Kessler, S. Y. Lim, R. J. Muschel   +13 more
doaj   +2 more sources

Citrullination in tumor immunity and therapy

The Journal of Clinical Investigation
Peptidyl arginine deiminases (PADs) catalyze the conversion of arginine residues into peptidyl citrulline, a posttranslational modification known as protein citrullination (or arginine deimination).
Michael R. Pitter, Weiping Zou
doaj   +3 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The role of SERPIN citrullination in thrombosis

, 2022
Aberrant protein citrullination is associated with many pathologies; however, the specific effects of this modification remain unknown. We have previously demonstrated that serine protease inhibitors (SERPINs) are highly citrullinated in rheumatoid ...
Wagner, Denisa, Gutch, Sarah, Sorvillo, Nicoletta, Salinger, Ari J., Cherpokova, Deya, Reyes, Archie C., Thompson, Paul R, Fukui, Saeko, Tilvawala, Ronak, Nemmara, Venkatesh V.   +9 more
core   +1 more source

Citrullination in Cancer [PDF]

Cancer Research, 2019
Abstract Posttranslational modifications of proteins have been implicated in pathogenesis of numerous diseases. Arginine deimination (also known as citrullination) has a principal role in progression of rheumatoid arthritis through generation of autoantibodies and exacerbation of the inflammatory response.
openaire   +2 more sources