Results 31 to 40 of about 310,804 (186)

Rheumatoid arthritis sera antibodies to citrullinated collagen type II bind to joint cartilage

Arthritis Research & Therapy, 2022
Objective To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint cartilage.
Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao, Rikard Holmdahl   +13 more
doaj   +1 more source

Optimizing the identification of citrullinated peptides by mass spectrometry:utilizing the inability of trypsin to cleave after citrullinated amino acids [PDF]

, 2013
Citrullinated proteins have been associated with several diseases and citrullination can most likely function as a target for novel diagnostic agents and unravel disease etiologies.
Lauridsen, Kasper, Stensballe, Allan; id_orcid, Andersen, Vibeke, Bennike, Tue; id_orcid, Lauridsen, Kasper B., Olesen, Michael Kruse, Birkelund, Svend; id_orcid   +6 more
core   +1 more source

Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients

Frontiers in Immunology, 2023
Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients.
Minjie Xu, Rong Du, Wenping Xing, Xueting Chen, Jian Wan, Shengqing Wang, Li Xiong, Kutty Selva Nandakumar, Rikard Holmdahl, Hui Geng   +9 more
doaj   +1 more source

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells [PDF]

, 2011
Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator.
Ireland, Jamie M, Jamie M. Ireland, Unanue, Emil R, Emil R. Unanue   +3 more
core   +1 more source

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens [PDF]

, 2015
Introduction: We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of those citrullinated peptides, and ...
Klareskog, Lars, Fernandes-Cerqueira, C, Lars Klareskog, Cátia Fernandes-Cerqueira, Mathsson, L, Ossipova, Elena, Hansson, M,, Klareskog, L,, Anca I. Catrina, Gunasekera, Sunithi,, Rönnelid, Johan, Sunithi Gunasekera, Ronnelid, J, Lundberg, K,, Rönnelid, Johan,, Göransson, Ulf,, Catrina, Anca I., Fernandes-Cerqueira, Catia, Johan Rönnelid, Monika Hansson, Linda Mathsson, Per-Johan Jakobsson, Yngve Sommarin, Göransson, Ulf, Sommarin, Yngve, Karin Lundberg, Lundberg, Karin, Ulf Göransson, Gunasekera, Sunithi, Sommarin, Y, Mathsson, Linda, Ossipova, E, Jakobsson, Per-Johan, Mathsson, Linda,, Catrina, AI, Hansson, Monika, Elena Ossipova, Gunasekera, S   +37 more
core   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Guido Valesini, Alessandra Nerviani, CAPOZZI, ANTONELLA, Tina Garofalo, LOCOCO, Emanuela, Roberta Misasi, GAROFALO, TINA, Manuela Di Franco, Michele Bombardieri, Maurizio Sorice, Nerviani, Alessandra, Valeria Manganelli, Antonella Capozzi, IANNUCCELLI, Cristina, ALESSANDRI, cristiano, DI FRANCO, Manuela, Cristiano Alessandri, Bombardieri, Michele, MISASI, Roberta, SORICE, Maurizio, MANGANELLI, VALERIA, VALESINI, Guido, Cristina Iannuccelli, Emanuela Lococo   +23 more
core   +1 more source

In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

Frontiers in Immunology, 2021
ObjectivesRheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino
Guillaume Larid, Mikael Pancarte, Géraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Jean Roudier, Guy Serre, Nathalie Balandraud, Nathalie Balandraud   +12 more
doaj   +1 more source

Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells. [PDF]

, 2010
OF THE DISSERTATION Presentation of citrullinated peptides derived from unmodified protein by antigen presenting cells. By Jamie Michelle Rimer Doctor of Philosophy in Biology and Biomedical Sciences: Immunology) Washington University in St.
Rimer, Jamie
core   +1 more source