Results 21 to 30 of about 6,340 (217)
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
Rheumatology, 2016 Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of citrullinated peptides, with consequent breakage of tolerance.
SORICE, Maurizio +11 more
openaire +2 more sources
Frontiers in Immunology, 2022 The critical immunological event in rheumatoid arthritis (RA) is the production of antibodies to citrullinated proteins (ACPAs), ie proteins on which arginines have been transformed into citrullines by peptidyl arginine deiminases (PAD).
Marie F. Hemon +6 more
doaj +1 more source
Tolerogenic citrullinated peptide for arthritis
Oncotarget, 2015 Disease-specific autoantibodies directed against post-translation citrullinated proteins/peptides (ACPAs) are specific serological markers for rheumatoid arthritis (RA) and have been accepted as one of the classification criteria for the disease. Beyond diagnosis these autoantibodies have also been shown also to predict disease severity.
Smadar, Gertel +2 more
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Collision-Induced Dissociation of Citrullinated Peptide Anions
Journal of the American Society for Mass Spectrometry, 2023 Peptide identification by positive electrospray ionization (ES+) tandem mass spectrometry (MS/MS) is a well-established strategy in proteomics. Several research groups reported the usefulness of negative electrospray ionization (ES-) for gaining complementary structural information on peptides and their post-translational modifications (PTM) compared ...
Arnold Steckel +3 more
openaire +2 more sources
Frontiers in Immunology, 2019 Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS ...
Wolfgang Faigle +11 more
doaj +1 more source
Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy
Frontiers in Immunology, 2022 IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which ...
Victoria Anne Brentville +15 more
doaj +1 more source
A technique for the specific enrichment of citrulline-containing peptides [PDF]
Analytical Biochemistry, 2010 Protein citrullination results from enzymatic deimination of peptidylarginine and plays an important role in health and disease. Despite increasing scientific interest, the identity and function of citrullinated proteins in vivo remain widely unknown.
Astrid E V, Tutturen +5 more
openaire +2 more sources
Citrullination only infrequently impacts peptide binding to HLA class II MHC. [PDF]
PLoS ONE, 2017 It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination.
John Sidney +11 more
doaj +1 more source
Frontiers in Immunology, 2022 Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Natalia Sherina +36 more
doaj +1 more source
Molecules, 2012 Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides.
Ramon Eritja +4 more
doaj +1 more source