Results 21 to 30 of about 310,804 (186)

The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

PLoS ONE, 2021
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins.
Stephane Becart, Karen B Whittington, Amanda Prislovsky, Navin L Rao, Edward F Rosloniec   +4 more
doaj   +1 more source

Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF [PDF]

Clinical Rheumatology, 2016
Min Xu, Jianning Zhao, Xiao-Jun Li
exaly   +2 more sources

PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays

Frontiers in Immunology, 2022
The critical immunological event in rheumatoid arthritis (RA) is the production of antibodies to citrullinated proteins (ACPAs), ie proteins on which arginines have been transformed into citrullines by peptidyl arginine deiminases (PAD).
Marie F. Hemon, Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Jean Roudier, Isabelle Auger   +6 more
doaj   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Rikard Holmdahl, Bockermann, Robert, Hüseyin Uysal, Sehnert, Bettina,, Harald Burkhardt, Robert Bockermann, Bockermann, R, Nandakumar, Kutty S, Bajtner, Estelle,, Engstrom, A, Thunnissen, Marjolein M G M, Uysal, H,, Serre, Guy, Serre, G, Holmdahl, R,, Nandakumar, Kutty Selva,, Bajtner, E, Holmdahl, Rikard, Uysal, Hüseyin,, Burkhardt, Harald,, Burkhardt, H, Kutty Selva, Nandakumar,, Kutty S. Nandakumar, Bettina Sehnert, Thunnissen, MMGM, Serre, Guy,, Nandakumar, Kutty S., Burkhardt, Harald, Engström, Åke, Thunnissen, Marjolein,, Guy Serre, Engström, Åke,, Thunnissen, Marjolein M. G. M., Thunnissen, Marjolein M. G. M.,, Sehnert, B, Åke Engström, Sehnert, Bettina, Kutty Selva, Nandakumar, Nandakumar, KS, Estelle Bajtner, Lund University., Bajtner, Estelle, Thunnissen, Marjolein, Marjolein M.G.M. Thunnissen, Bockermann, Robert,, Holmdahl, Rikard,, Uysal, Hüseyin   +46 more
core   +1 more source

Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

Frontiers in Immunology, 2019
Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS ...
Wolfgang Faigle, Carolina Cruciani, Witold Wolski, Bernd Roschitzki, Marco Puthenparampil, Paula Tomas-Ojer, Carla Sellés-Moreno, Thomas Zeis, Ivan Jelcic, Nicole Schaeren-Wiemers, Mireia Sospedra, Roland Martin   +11 more
doaj   +1 more source

Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy

Frontiers in Immunology, 2022
IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which ...
Victoria Anne Brentville, Peter Symonds, JiaXin Chua, Anne Skinner, Ian Daniels, Katherine Wendy Cook, Sasa Koncarevic, Roxana Martinez-Pinna, Sabaria Shah, Ruhul Hasan Choudhury, Poonam Vaghela, Daisy Weston, Abdullah Al-Omari, James Davis, Lindy G. Durrant, Lindy G. Durrant   +15 more
doaj   +1 more source

Oligonucleotide-Peptide Conjugates: Solid-Phase Synthesis under Acidic Conditions and Use in ELISA Assays

Molecules, 2012
Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides.
Ramon Eritja, Isabel Haro, Morteza Malakoutikhah, Maria José Gómara, Anna Aviñó   +4 more
doaj   +1 more source

Citrullination only infrequently impacts peptide binding to HLA class II MHC. [PDF]

PLoS ONE, 2017
It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination.
John Sidney, Stephane Becart, Mimi Zhou, Karen Duffy, Mikaela Lindvall, Erin C Moore, Eugene L Moore, Tadimeti Rao, Navin Rao, Morten Nielsen, Bjoern Peters, Alessandro Sette   +11 more
doaj   +1 more source

Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology

Frontiers in Immunology, 2022
Based on the epidemiological link between periodontitis and rheumatoid arthritis (RA), and the unique feature of the periodontal bacterium Porphyromonas gingivalis to citrullinate proteins, it has been suggested that production of anti-citrullinated ...
Natalia Sherina, Charlotte de Vries, Nastya Kharlamova, Natalie Sippl, Xia Jiang, Boel Brynedal, Elin Kindstedt, Elin Kindstedt, Monika Hansson, Linda Mathsson-Alm, Linda Mathsson-Alm, Lena Israelsson, Ragnhild Stålesen, Saedis Saevarsdottir, Saedis Saevarsdottir, Rikard Holmdahl, Aase Hensvold, Aase Hensvold, Gunnar Johannsen, Gunnar Johannsen, Kaja Eriksson, Kaja Eriksson, Federica Sallusto, Federica Sallusto, Anca I. Catrina, Anca I. Catrina, Johan Rönnelid, Caroline Grönwall, Tülay Yucel-Lindberg, Tülay Yucel-Lindberg, Lars Alfredsson, Lars Alfredsson, Lars Klareskog, Luca Piccoli, Vivianne Malmström, Khaled Amara, Karin Lundberg   +36 more
doaj   +1 more source

Immunomodulation of RA Patients’ PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens

Mediators of Inflammation, 2017
Citrullinated peptides are used for measuring anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). Accumulation of citrullinated proteins in the inflamed synovium suggests that they may be good targets for inducing peripheral ...
Smadar Gertel, Gidon Karmon, Sivan Vainer, Ora Shovman, Martin Cornillet, Guy Serre, Yehuda Shoenfeld, Howard Amital   +7 more
doaj   +1 more source