Results 11 to 20 of about 5,161 (175)

Adalimumab-Induced Rhupus Syndrome in a Female Patient Affected with Anti-Citrullinated Protein Antibody (ACPA)-Positive Rheumatoid Arthritis (RA): A Case Report and Review of Literature [PDF]

Clinics and Practice, 2021
We report a 38-year-old female patient affected with anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA) who developed mild hemolytic anemia (Hb = 10.5 vs. >12 gr/dL), indolent oral ulceration, ANA (1:1280, homogeneous pattern),
Ciro Manzo, Alberto Castagna
doaj   +3 more sources

FRI0519 IDENTIFICATION OF CELLULAR TARGETS FOR ANTI-CITRULLINATED PROTEIN ANTIBODIES (ACPAS) [PDF]

Annals of the Rheumatic Diseases, 2019
Background Autoantibodies against citrullinated proteins (ACPAs) have been suggested to play important roles in RA pathogenesis (1-3). Objectives In order to further dissect how ACPAs influence bone homeostasis and inflammation in the joints we analyzed the binding of different ACPA clones to target antigens produced by synovial fibroblasts ...
Bence Réthi, Meng Sun, Alexandra Circiumaru, Akilan Krishnamurthy, Heidi Wähämaa, Jimmy Ytterberg, Vivianne Malmström, Lars Klareskog, Anca Catrina   +8 more
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Anti-citrullinated Protein Antibody Generation, Pathogenesis, Clinical Application, and Prospects

Frontiers in Medicine, 2022
Anti-citrullinated protein antibodies (ACPAs) are autoantibodies commonly observed in patients with rheumatoid arthritis (RA). Currently, most of the mechanisms of ACPA formation and bone destruction are well-understood, however, some unknown mechanisms ...
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang   +9 more
doaj   +1 more source

Biosensor analysis of anti-citrullinated protein/peptide antibody affinity [PDF]

Analytical Biochemistry, 2014
Anti-citrullinated protein/peptide antibodies (ACPAs) are detected in rheumatoid arthritis (RA) sera and because of their strict association with the disease are considered marker antibodies, probably endowed with pathogenic potential. Antibody affinity is one of the parameters affecting pathogenicity.
ROSSI, GIADA, REAL FERNANDEZ, FELICIANA, Filomena Panza, Francesca Barbetti, Federico Pratesi, ROVERO, PAOLO, Paola Migliorini   +6 more
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Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies

Frontiers in Immunology, 2021
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate ...
Pauline Brevet, Pauline Brevet, Claire Lattard, Claire Lattard, Clément Guillou, Pascal Rottenberg, Patrice Fardellone, Xavier Le-Loët, Thierry Lequerré, Thierry Lequerré, Pascal Cosette, Olivier Boyer, Olivier Boyer, Manuel Fréret, Manuel Fréret, Olivier Vittecoq, Olivier Vittecoq   +16 more
doaj   +1 more source

Anti-Carbamylated Protein Antibodies as a Reproducible Independent Type of Rheumatoid Arthritis Autoantibodies. [PDF]

PLoS ONE, 2016
A large fraction of the patients with rheumatoid arthritis (RA) develop specific autoantibodies, which until recently were only of two types, rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA).
Ariana Montes, Cristina Regueiro, Eva Perez-Pampin, Maria Dolores Boveda, Juan J Gomez-Reino, Antonio Gonzalez   +5 more
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In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

Frontiers in Immunology, 2021
ObjectivesRheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino
Guillaume Larid, Mikael Pancarte, Géraldine Offer, Cyril Clavel, Marielle Martin, Vincent Pradel, Isabelle Auger, Pierre Lafforgue, Jean Roudier, Jean Roudier, Guy Serre, Nathalie Balandraud, Nathalie Balandraud   +12 more
doaj   +1 more source

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Arthritis Research & Therapy, 2017
Background Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have
Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw   +4 more
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Presence of autoantibodies in “seronegative” rheumatoid arthritis associates with classical risk factors and high disease activity

Arthritis Research & Therapy, 2020
Background Rheumatoid arthritis (RA) is classified as seropositive or seronegative, depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti-citrullinated protein antibodies (ACPA), commonly detected using anti-cyclic ...
Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid, Karin Lundberg   +13 more
doaj   +1 more source

Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis.

PLoS ONE, 2021
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which anti-citrullinated protein antibodies (ACPA) are most prominent.
Linda M Slot, Rochelle D Vergroesen, Priscilla F Kerkman, Ellen Staudinger, Sanne Reijm, Hugo J van Dooren, Ellen I H van der Voort, Tom W J Huizinga, René E M Toes, Hans U Scherer   +9 more
doaj   +1 more source