Results 21 to 30 of about 5,161 (175)

Low avidity anti-citrullinated protein antibodies (ACPA) are associated with high radiographic progression in rheumatoid arthritis [PDF]

Annals of the Rheumatic Diseases, 2011
Background and objectives Anti-citrullinated protein antibodies (ACPA) are specific for Rheumatoid Arthritis (RA). Their presence is predictive for development to RA and they have been implicated in disease-pathogenesis in animal studies. The biology of the ACPA response and its consequence are poorly studied in humans. We have shown that ACPA display
P. Suwannalai, H.U. Scherer, A. Ioan-Facsinay, Jol-van der Zijde, M.J.D. van Tol, A.H. Van der Helm-van Mil, R. Knevel, T.W.J. Huizinga, R.E.M. Toes, L.A. Trouw   +9 more
openaire   +1 more source

Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4

Scientific Reports, 2023
Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka   +6 more
doaj   +1 more source

Clinical and etiological meaning of anti-carbamylated protein antibodies in rheumatoid arthritis

Immunological Medicine, 2019
Several autoantibodies against proteins with post-translational modifications have been detected in patients with rheumatoid arthritis (RA) and are called anti-modified protein antibodies (AMPAs).
Shuichiro Nakabo
doaj   +1 more source

Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]

PLoS ONE, 2016
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng, Peyman Ezzati, Irene Smolik, Charles N Bernstein, Carol Ann Hitchon, Hani S El-Gabalawy   +5 more
doaj   +1 more source

The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti‐citrullinated protein antibody) formation [PDF]

Journal of Clinical Periodontology, 2012
AbstractAimTo determine the presence and location (stroma versus epithelium) of citrullinated proteins in periodontitis tissue as compared to non‐periodontitis tissue and synovial tissue of RA patients.Materials & MethodsPeriodontitis, healthy periodontal and RA‐affected synovial tissue samples were collected in addition to buccal swabs.
Nesse, Willem, Westra, Johanna, van der Wal, Jacqueline E., Abbas, Frank, Nicholas, Anthony P., Vissink, Arjan, Brouwer, Elisabeth, Westra J., [No Value]   +7 more
openaire   +2 more sources

HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis

PLoS ONE, 2013
To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype.We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 ...
Balandraud, Nathalie, Picard, Christophe, Reviron, Denis, Landais, Cyril, Toussirot, Eric, Lambert, Nathalie, Telle, Emmanuel, Charpin, Caroline, Wendling, Daniel, Pardoux, Etienne, Auger, Isabelle, Roudier, Jean   +11 more
openaire   +5 more sources

IgA anti-citrullinated protein antibodies are associated with flares during DMARD tapering in rheumatoid arthritis

Rheumatology, 2021
Abstract Objectives A substantial proportion of RA patients flare upon withdrawal of DMARDs, and thus the definition of prognostic markers is crucial. ACPA positivity has been identified as a risk factor for flare.
Maria V Sokolova, Melanie Hagen, Holger Bang, Georg Schett, Juergen Rech, Ulrike Steffen, Judith Haschka, Matthias Englbrecht, Axel J Hueber, Bernhard Manger, Arnd Kleyer, Michaela Reiser, Stephanie Finzel, Hans-Peter Tony, Stefan Kleinert, Martin Feuchtenberger, Martin Fleck, Karin Manger, Wolfgang Ochs, Matthias Schmitt-Haendle, Joerg Wendler, Florian Schuch, Monika Ronneberger, Hanns-Martin Lorenz, Hubert Nuesslein, Rieke Alten, Winfried Demary, Joerg Henes   +27 more
openaire   +3 more sources

Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2019
Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Katy A. Lloyd, Gustaf Wigerblad, Gustaf Wigerblad, Peter Sahlström, Peter Sahlström, Manasa G. Garimella, Karine Chemin, Johanna Steen, Philip J. Titcombe, Philip J. Titcombe, Bianka Marklein, Diana Zhou, Ragnhild Stålesen, Elena Ossipova, Christina Lundqvist, Olov Ekwall, Olov Ekwall, Johan Rönnelid, Daniel L. Mueller, Mikael C. I. Karlsson, Mariana J. Kaplan, Karl Skriner, Lars Klareskog, Fredrik Wermeling, Vivianne Malmström, Caroline Grönwall   +25 more
doaj   +1 more source

Pitfalls in Diagnosing Seropositive Rheumatoid Arthritis: Haematologic Malignancy Presenting as an Autoimmune Disease [PDF]

Journal of Clinical and Diagnostic Research, 2018
Carcinomatous Polyarthritis (CP) is defined as the development of arthritis in association with a malignancy but distinct from that associated with metastasis or direct invasion.
Bijit Kumar Kundu, Eashan Srivastava, Vijesh Vijayan, B Manojprabhakaran, Mukesh Verma   +4 more
doaj   +1 more source

CD95-Mediated control of anti-citrullinated protein/peptides antibodies (ACPA)-producing plasma cells occurring in rheumatoid arthritis inflamed joints [PDF]

Rheumatology, 2006
Serum anti-citrullinated protein/peptides antibodies (ACPA) are a valuable diagnostic parameter that might be involved in rheumatoid arthritis (RA) pathogenesis. CD95-dependent apoptosis is defective in RA synovium. The present study explores the occurrence of ACPA IgG, and the CD95-mediated control of ACPA IgG-secreting plasma cells (PC) in RA ...
Beatriz, Rodríguez-Bayona, José J, Pérez-Venegas, Carmen, Rodríguez, José A, Brieva   +3 more
openaire   +2 more sources