Low avidity anti-citrullinated protein antibodies (ACPA) are associated with high radiographic progression in rheumatoid arthritis [PDF]
Background and objectives Anti-citrullinated protein antibodies (ACPA) are specific for Rheumatoid Arthritis (RA). Their presence is predictive for development to RA and they have been implicated in disease-pathogenesis in animal studies. The biology of the ACPA response and its consequence are poorly studied in humans. We have shown that ACPA display
P. Suwannalai +9 more
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Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4
Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida +6 more
doaj +1 more source
Clinical and etiological meaning of anti-carbamylated protein antibodies in rheumatoid arthritis
Several autoantibodies against proteins with post-translational modifications have been detected in patients with rheumatoid arthritis (RA) and are called anti-modified protein antibodies (AMPAs).
Shuichiro Nakabo
doaj +1 more source
Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins. [PDF]
Anti-citrullinated protein antibodies (ACPA) have become an integral part of the clinical definition of rheumatoid arthritis, and are hypothesized to be important in the immunopathogenesis of this autoimmune disease.
Xiaobo Meng +5 more
doaj +1 more source
The periodontium of periodontitis patients contains citrullinated proteins which may play a role in
AbstractAimTo determine the presence and location (stroma versus epithelium) of citrullinated proteins in periodontitis tissue as compared to non‐periodontitis tissue and synovial tissue of RA patients.Materials & MethodsPeriodontitis, healthy periodontal and RA‐affected synovial tissue samples were collected in addition to buccal swabs.
Nesse, Willem +7 more
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To provide a table indicating the risk for developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis (RA) according to one's HLA-DRB1 genotype.We HLA-DRB1 genotyped 857 patients with ACPA positive RA and 2178 controls from South Eastern and Eastern France and calculated Odds Ratios (OR) for developing RA for 106 of 132 ...
Balandraud, Nathalie +11 more
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Abstract Objectives A substantial proportion of RA patients flare upon withdrawal of DMARDs, and thus the definition of prognostic markers is crucial. ACPA positivity has been identified as a risk factor for flare.
Maria V Sokolova +27 more
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Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with
Katy A. Lloyd +25 more
doaj +1 more source
Pitfalls in Diagnosing Seropositive Rheumatoid Arthritis: Haematologic Malignancy Presenting as an Autoimmune Disease [PDF]
Carcinomatous Polyarthritis (CP) is defined as the development of arthritis in association with a malignancy but distinct from that associated with metastasis or direct invasion.
Bijit Kumar Kundu +4 more
doaj +1 more source
CD95-Mediated control of anti-citrullinated protein/peptides antibodies (ACPA)-producing plasma cells occurring in rheumatoid arthritis inflamed joints [PDF]
Serum anti-citrullinated protein/peptides antibodies (ACPA) are a valuable diagnostic parameter that might be involved in rheumatoid arthritis (RA) pathogenesis. CD95-dependent apoptosis is defective in RA synovium. The present study explores the occurrence of ACPA IgG, and the CD95-mediated control of ACPA IgG-secreting plasma cells (PC) in RA ...
Beatriz, Rodríguez-Bayona +3 more
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