Results 31 to 40 of about 5,161 (175)

AB0179 INFLUENCE OF AINFLUENCE OF ANTI-CITRULLINATED PROTEIN/PEPTIDE ANTIBODIES (ACPAS)ON ARTICULAR MANIFESTATIONS, DISEASE ACTIVITY AND STRUCTURAL SEVERITY IN ALGERIAN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS [PDF]

Annals of the Rheumatic Diseases, 2021
Background: Anti-citrullinated protein/peptide antibodies (ACPA) are highly specific and sensitive markers for rheumatoid arthritis (RA). There are also suggested to have a more severe rheumatoid arthritis. Objectives: The aim of this study was to assess the influence of ACPA on disease activity, radiological severity, and functional disability in ...
F. Rahal, N. Brahumi, A. Ladjouze-Rezig, S. Lefkir   +3 more
openaire   +1 more source

Autoantibodies against citrullinated serum albumin in patients with rheumatoid arthritis

Journal of Translational Autoimmunity, 2019
Rheumatoid arthritis (RA) is a chronic, potentially debilitating, inflammatory disease that primarily affects synovial joints. While the etiology of RA remains incompletely understood, it is clear that the disease is autoimmune in nature.
Amanda Hefton, Shu Ying Liang, Kathryn Ni, Victoria Carter, Kennedy Ukadike, Christian Lood, Tomas Mustelin   +6 more
doaj   +1 more source

The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA/RF negative rheumatoid arthritis patients

Therapeutic Advances in Musculoskeletal Disease, 2021
Background: Anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are key factors in the American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis (RA) classification criteria markers.
Bogdan Kolarz, Marek Ciesla, Ann K. Rosenthal, Magdalena Dryglewska, Maria Majdan   +4 more
doaj   +1 more source

Antibodies to leukotoxin A from the periodontal pathogen Aggregatibacter actinomycetemcomitans in patients at an increased risk of rheumatoid arthritis

Frontiers in Medicine, 2023
ObjectivesPeriodontitis and underlying bacteria have been linked to the development of rheumatoid arthritis (RA). One suggested pathogen is Aggregatibacter actinomycetemcomitans (A.a.), which expresses leukotoxin A (LtxA) that can citrullinate human ...
Klara Martinsson, Andrea Di Matteo, Carina Öhman, Anders Johansson, Anna Svärd, Anna Svärd, Kulveer Mankia, Paul Emery, Alf Kastbom, Alf Kastbom   +9 more
doaj   +1 more source

Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.

PLoS ONE, 2016
BackgroundRheumatoid arthritis (RA) is an autoimmune disease of the synovial joints. The autoimmune character of RA is underscored by prominent production of autoantibodies such as those against IgG (rheumatoid factor), and a broad array of joint tissue ...
Tibor T Glant, Timea Ocsko, Adrienn Markovics, Zoltan Szekanecz, Robert S Katz, Tibor A Rauch, Katalin Mikecz   +6 more
doaj   +1 more source

Current view on the pathogenic role of anti-citrullinated protein antibodies in rheumatoid arthritis

RMD Open, 2021
Epidemiological findings suggest a potential role for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) pathogenesis.
Bence Rethi, Akilan Krishnamurthy, Anca Catrina   +2 more
doaj   +1 more source

Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population [PDF]

Arthritis Research & Therapy, 2015
Abstract Introduction Although susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by genome-wide association studies (GWAS), little is known about the genetic background of ACPA-negative RA.
Terao, Chikashi, Ohmura, Koichiro, Kochi, Yuta, Ikari, Katsunori, Okada, Yukinori, Shimizu, Masakazu, Nishina, Naoshi, Suzuki, Akari, Myouzen, Keiko, Kawaguchi, Takahisa, Takahashi, Meiko, Takasugi, Kiyoshi, Murasawa, Akira, Mizuki, Shinichi, Iwahashi, Mitsuhiro, Funahashi, Keiko, Natsumeda, Masamitsu, Furu, Moritoshi, Hashimoto, Motomu, Ito, Hiromu, Fujii, Takao, Ezawa, Kazuhiko, Matsubara, Tsukasa, Takeuchi, Tsutomu, Kubo, Michiaki, Yamada, Ryo, Taniguchi, Atsuo, Yamanaka, Hisashi, Momohara, Shigeki, Yamamoto, Kazuhiko, Mimori, Tsuneyo, Matsuda, Fumihiko   +31 more
openaire   +2 more sources

Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis

BMC Musculoskeletal Disorders, 2022
Objective Rheumatoid arthritis (RA) is often complicated with chronic lung diseases (CLD), including interstitial lung disease (ILD) and airway disease, which occur as extra-articular manifestations.
Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita, Shigeto Tohma   +13 more
doaj   +1 more source

Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2012
Background Anti-citrullinated protein/peptide antibodies (ACPA), have high specificity for rheumatoid arthritis (RA). Some children with juvenile idiopathic arthritis (JIA), phenotypically resemble RA and test positive for rheumatoid factor (RF) a ...
Tebo Anne E, Jaskowski Troy, Davis K, Whiting April, Clifford Bronte, Zeft Andrew, McNally Bernadette, Hill Harry R, Bohnsack John, Prahalad Sampath   +9 more
doaj   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source