Results 71 to 80 of about 809 (171)

Multi‐Autoantibody Testing Identifies Expansion of Reactivity to Targeted Antigens Before a Diagnosis of Rheumatoid Arthritis

ACR Open Rheumatology, Volume 6, Issue 9, Page 587-597, September 2024.
Objective Rheumatoid arthritis (RA) has a “pre‐RA” period in which multiple autoantibodies, including antibodies to citrullinated (cit) proteins (ACPA), rheumatoid factor (RF), anti–peptidyl arginine deiminase (anti‐PAD), among others, have been described; however, few studies have tested all autoantibodies in a single pre‐RA cohort. This study aims to
Salina H. Goff, Dylan T. Bergstedt, Marie L. Feser, LauraKay Moss, Ted R. Mikuls, Jess D. Edison, V. Michael Holers, Laura Martinez‐Prat, Mary Ann R. Aure, Michael Mahler, Kevin D. Deane   +10 more
wiley   +1 more source

Posttranslational Modifications and the Immunogenicity of Biotherapeutics

Journal of Immunology Research, Volume 2016, Issue 1, 2016., 2016
Whilst the amino acid sequence of a protein is determined by its gene sequence, the final structure and function are determined by posttranslational modifications (PTMs), including quality control (QC) in the endoplasmic reticulum (ER) and during passage through the Golgi apparatus.
Roy Jefferis, Leslie A. Khawli
wiley   +1 more source

The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis

Journal of Immunology Research, Volume 2015, Issue 1, 2015., 2015
The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions. The regulation of PTMs is crucial for the activity and survival of the cells. Dysregulation of PTMs has been observed in several pathological conditions, including rheumatoid arthritis (RA ...
Andrea Mastrangelo, Tania Colasanti, Cristiana Barbati, Arbi Pecani, Danilo Sabatinelli, Monica Pendolino, Simona Truglia, Laura Massaro, Riccardo Mancini, Francesca Miranda, Francesca Romana Spinelli, Fabrizio Conti, Cristiano Alessandri, David Kaplan   +13 more
wiley   +1 more source

Association of anti-pad4 antibodies with erosion and biological treatment use in rheumatoid arthritis. [PDF]

, 2019
Background: Novel biomarkers have been described in rheumatoid arthritis (RA) patients, including antibodies to carbamylated proteins (anti-CarP) and to protein-arginine deiminases (PAD).
Lopez-Hoyos, Marcos, Mahler, Michael, Martinez-Taboada, Victor, Martínez Prat, Laura   +3 more
core   +1 more source

Utility of Anti-Carbamylated Antibodies in Early Rheumatoid Arthritis in South Asian Population

Journal of Clinical Rheumatology and Immunology
Background: This study aimed to evaluate the correlation of anti-carbamylated protein (anti-CarP) antibodies with disease activity in Rheumatoid Arthritis (RA) patients, stratified by Rheumatoid Factor (RF) and/or anti-citrullinated peptide antibodies ...
Chandhu A S, Josna Joseph, John Mathew
doaj   +1 more source

A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis [PDF]

, 2020
The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anticitrullinated protein antibodies (ACPA) and RA ...
Alejandro Balsa, Alejandro Villalba, Alfonso Corrales, Ana M. Ortiz, Ana Martínez-Feito, Ana Triguero-Martinez, Antonio Mera-Varela, Benjamín Fernandez-Gutierrez, Carmen Conde, Cristina Regueiro, Eva Herranz, Eva Perez-Pampin, González-Gay Mantecón, Miguel Ángel, Isidoro Gonzalez-Alvaro, Laura Nuño, Luis Rodriguez-Rodriguez, Lydia Abasolo, Raquel Lopez-Mejias, Sara Remuzgo-Martínez, Yolanda Lopez-Golan   +19 more
core   +1 more source

Evaluation of anti-citrullinated and anti-carbamylated antibodies in mexicans with rheumatoid arthritis and at-risk individuals

Revista de Investigación Clínica
Background: Rheumatoid arthritis (RA) diagnosis is a challenge in the initial phases of the disease when clinical symptoms are only starting to develop.
Edgar E. Lara-Ramírez, Betzaida Cuevas-Córdoba, Diana Olguín-Calderon, Yadira Bastian, César Ramos-Remus, José D. Castillo-Ortiz, Martín Zapata-Zúñiga, Jesús Núñez-Contreras, Leendert A. Trouw, José A. Enciso-Moreno, Julio E. Castañeda-Delgado   +10 more
doaj   +1 more source

Laboratory biomarkers or imaging in the diagnostics of rheumatoid arthritis? [PDF]

, 2014
none3openŠenolt, Ladislav; Grassi, Walter; Szodoray, PeterŠenolt, Ladislav; Grassi, Walter; Szodoray ...
Grassi, Walter, Szodoray, Peter, Šenolt, Ladislav   +2 more
core   +2 more sources

Relation of cytokine profile and antibody values to post-translational protein modifications in patients with rheumatoid arthritis (preliminary data)

Научно-практическая ревматология
The aim of the study was to investigate the relationship between cytokine levels and values of antibodies to cyclic citrullinated peptide (anti-CCP) and antibodies to carbamylated proteins (anti-CarP) in patients with rheumatoid arthritis (RA). Materials
D. А. Dibrov, А. S. Avdeeva, М. Е. Diatroptov, V. V. Rybakova, Е. L. Nasonov   +4 more
doaj   +1 more source

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical

Arthritis Research & Therapy, 2017
Background Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflicting.
Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H. M. van der Helm-van Mil   +11 more
doaj   +1 more source