Results 111 to 120 of about 72,816 (294)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

The requirements of the airworthiness of aircraft [PDF]

, 2014
Cílem této práce je zjistit požadavky a postupy pro získání a zachování osvědčení letové způsobilosti letadel a výrobků letadlové techniky v rozsahu civilního letectví.
Pauliny, Jan
core  

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Study on the Influence of the Mechanical Characteristics of the Cutting-Type Anti-Climbing Energy Absorber on the Collision Behavior of the GFRP Head Cover for Subways

Machines
Anti-climbing energy absorbers (AEAs) are often installed at the ends of subway vehicles to prevent climbing in the event of a head-on collision or rear-end collision, thereby improving safety performance.
Xuan Liu, Ping Xu, Yifan Hu, Ying Gao, Dongtao Wang   +4 more
doaj   +1 more source

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Smart Vehicle System Using Arduino [PDF]

, 2019
Transportation is a basic need of society and with the increasing population; indirectly there is an increase in the vehicle density, which may lead to many road accidents resulting in injuries and sometimes lead to death. To prevent this particularly, a
Borah, M. P. (Manash), Das, A. (Animesh), Dey, S. (Smriti), Kaur, P. (Parveen)   +3 more
core   +1 more source

Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels

Advanced Science, EarlyView.
We introduce a novel, ion‐targeted strategy to enhance calcium permeation in voltage gated calcium channels. By directly driving the ions’ coherent collective motion via resonant coupling with a 1.65 THz field, we lower the inter‐site energy barrier, inducing a statistically significant enhancement of ion influx.
Zihao Zhang, Yuankun Sun, Xinqiao Zhou, Sunchao Huang, Shengpeng Yang, Shaomeng Wang, Yubin Gong   +6 more
wiley   +1 more source

Micromachined Millimetre-Wave Passive Components at 38 and 77 GHz [PDF]

, 2009
A precision micro-fabrication technique has been developed for millimetre-wave components of air-filled three-dimensional structures, such as rectangular coaxial lines or waveguides.
Huang, F., Ke, M., Lancaster, M.J., Lewis, R., Wang, Yi   +4 more
core  

Transparent Photothermal Slippery Surface Based on Monolayer Self‐Assembled MXene Film for Anti‐Fogging and De‐Icing

Advanced Science, EarlyView.
The ultrathin (2.5 nm) MXene film self‐assembled at liquid interfaces breaks the trade‐off between transparency (82.5 %) and photothermal conversion effect (DT∼25.1°C ± 2.9 °C) under 100 mW cm−2. After encapsulated by a slippery surface with low adhesion, this transparent film can be applied in smart windows, eyewear, and optical sensors to autonomous ...
Xiao Han, Yiming Xie, Mingjia Sun, Di Zhao, Kesong Liu, Liping Heng, Lei Jiang   +6 more
wiley   +1 more source

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source