Results 71 to 80 of about 796 (295)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaporation-Rate Control of Water Droplets on Flexible Transparent Heater for Sensor Application

Sensors, 2019
To develop high-performance de- or anti-frosting/icing devices based on transparent heaters, it is necessary to study the evaporation-rate control of droplets on heater surfaces.
Jaesoung Park, Suhan Lee, Dong-Ik Kim, Young-You Kim, Samsoo Kim, Han-Jung Kim, Yoonkap Kim   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Experimental Study of Frost Accretion on Hydrophilic and Hydrophobic Substrates under Forced Convection Conditions [PDF]

, 2018
The present study is aimed at investigating, by means of an experimental approach, the effect of surface wettability on the frost accretion over horizontal flat surfaces under forced convection conditions. A purpose-built closed-loop wind-tunnel facility
Cardoso, Rodrigo P., Hermes, Christian, Loyola, Felipe, Nascimento, Valter, Sommers, Andrew   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Slippery Liquid Infused Porous TiO₂/SnO₂ Nanocomposite Thin Films via Aerosol Assisted Chemical Vapor Deposition with Anti-Icing and Fog Retardant Properties [PDF]

, 2019
Exceptional anti-icing and antifogging devices have been synthesized through combination of micro- and/or nanoscale hierarchical thin films followed by a modification with a surface lubricant.
Carmalt, CJ, Heale, FL, Parkin, IP
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Fabrication of SiO2/PDMS/EP superhydrophobic coating for anti-icing

Resources Chemicals and Materials
In low-temperature environments, the condensation and icing phenomena of water molecules on material surfaces may adversely affect the functionality and durability of various products, so it is critical to improve the anti-icing properties of material ...
Shiyuan Zhou, Jingran Chen, Shuai Huang
doaj   +1 more source

Liquid-liquid displacement in slippery liquid-infused membranes (SLIMs) [PDF]

, 2018
Liquid-infused membranes inspired by slippery liquid-infused porous surfaces (SLIPS) have been recently introduced to membrane technology. The gating mechanism of these membranes is expected to give rise to anti-fouling properties and multi-phase ...
Bazyar, Hanieh, Lammertink, Rob G.H., Lohse, Detlef, Lv, Pengyu, Porada, Slawomir, Wood, Jeffery A.   +5 more
core   +3 more sources