Results 121 to 130 of about 74,493 (218)

Pneumocystis pneumonia secondary to intensive immunosuppression treatment for anti-GBM disease complicated with IgA nephropathy: A case report and literature review. [PDF]

Medicine (Baltimore), 2021
Zhang M, Yang D, Wang W, Zhao F, Zhang X, Li X.   +5 more
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Antiglomerular basement membrane (anti-GBM) disease with clinical and histological features that bridge the typical to atypical spectrum. [PDF]

BMJ Case Rep, 2021
Fouhy F, Mayer N, Burke L, O'Shaughnessy M.   +3 more
europepmc   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Shugoshin proteins SGO1 and SGO2 regulate chromosome cohesion and segregation during mitosis and meiosis, and their aberrant expression is implicated in several cancers. However, the mechanistic involvement of these two proteins in papillary renal cell carcinoma (KIRP) and their contribution to immune evasion remains unclear ...
Han Fu, Alisherjon Ibrohimov, Hao Zheng, Yue Pan, Jieyu Hu, Banzhan Ruan, Hang Huang, Shi Li   +7 more
wiley   +1 more source

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

A Stacked Ensemble Multi‐Label Model for Predicting Co‐Occurring Microvascular and Macrovascular Complications in Type 2 Diabetes

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 151-160, June 2026.
Feature importance for predicting multiple diabetes complications based on a Stacking‐Classifier Chain model. ABSTRACT Background Type 2 diabetes mellitus (T2DM) leads to severe microvascular and macrovascular complications. Traditional single‐label prediction models fail to capture their co‐occurring nature.
Maryam Zamani, Maryam Farhadian, Nasrin Piran, Shiva Borzouei   +3 more
wiley   +1 more source