Results 121 to 130 of about 6,619,911 (229)

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Serum matrix metalloproteinase-9 levels and enzymatic activity in patients with anti-glomerular basement membrane disease

Frontiers in Medicine
BackgroundAnti-glomerular basement membrane (anti-GBM) disease is an autoimmune disorder with autoantibodies against GBM component, non-collagenous domain of the α3 chain of type IV collagen, α3(IV)NC1. Matrix metalloproteinase-9 (MMP-9) is an endogenous
Huang Kuang, Huang Kuang, Huang Kuang, Huang Kuang, Hong-shan Wan, Hong-shan Wan, Hong-shan Wan, Hong-shan Wan, Qiu-hua Gu, Qiu-hua Gu, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +21 more
doaj   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

A unique case of anti-GBM disease with concomitant anti-PLA2R positivity. [PDF]

BMC Nephrol, 2022
Molnár A, Tislér A, Dobi D, Pethő Á.
europepmc   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Case Report: Anti-glomerular basement membrane disease during pregnancy with favorable renal outcome, sequential biopsies, and dual anti-α1/α3(IV) and anti-LM521 antibodies

Frontiers in Immunology
Anti-glomerular basement membrane (anti-GBM) disease during pregnancy is rare and often life-threatening. We report a G4P1 woman who developed atypical anti-GBM disease at 13 weeks of gestation.
Jing Zhuang, Siwen Gu, Yue Qu, Changrong Zhang, Huang Kuang, Huang Kuang, Huang Kuang, Huang Kuang, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Xuefei Tian, Hong Jiang   +13 more
doaj   +1 more source

Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report. [PDF]

Medicine (Baltimore), 2022
Shaojie F, Sensen S, Jingda H, Luyu W, Fei Z, Jinyu Y, Zhonggao X, Hao W.   +7 more
europepmc   +1 more source

Goodpasture's disease with late presentation of renal abnormality and anti-GBM autoantibody

, 2017
Goodpasture's disease without circulating autoantibodies is a rare presentation of a rare diagnosis. We present the case of a man aged 17 years who had 3 hospital admissions over a 2-month period with haemoptysis and shortness of breath.
Sohail, S., Yadavilli, R., Boardman, Emily, Rajesh Yadavilli, Sameira Sohail, Emily Ann Boardman   +5 more
core   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source