Results 131 to 140 of about 6,619,911 (229)
Frontiers in ImmunologyBackgroundAnti-glomerular basement membrane (GBM) disease represents the most severe form of crescentic glomerulonephritis. Previous studies demonstrated that Bowman’s capsule rupture contributed to the progression of crescentic glomerulonephritis ...
Huang Kuang +23 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
Case Reports in Nephrology and DialysisIntroduction: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune vasculitis that often leads to rapidly progressive glomerulonephritis and poor renal prognosis.
Cheng Xue +7 more
doaj +1 more source
ANCA-Associated Vasculitis With Anti-GBM Disease and Two Types of Tumors: A Case Report. [PDF]
Front Med (Lausanne), 2021 Li X, Huang M, Liu J.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang +5 more
wiley +1 more source
Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy
Cancer Science, EarlyView.This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang +6 more
wiley +1 more source
Anti-glomerular basement membrane (anti-GBM) disease: the challenges in diagnosis and the choice of treatment [PDF]
Anti–glomerular basement membrane (anti-GBM) antibody disease is an autoimmune disorder. The majority of patients develop widespread glomerular crescent formation, presenting with features of rapidly progressive glomerulonephritis (RPGN). The etiology is
Li, Li Kwan +4 more
core
Cancer Science, EarlyView.An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang +10 more
wiley +1 more source
Relapse of treated anti-GBM disease following hair dye use. [PDF]
BMJ Case Rep, 2021 Povey J +3 more
europepmc +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source