Results 131 to 140 of about 74,493 (218)

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

DRAM1‐defined autophagy‐JAK‐STAT‐Tregs axis drives immunosuppression and predicts immunotherapy response in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu, Hailing Yang, Jingjing Cao, Min Yang, Wanqiao Cao, Yonglei Liu, Yunfeng Cheng, Fanli Hua   +7 more
wiley   +1 more source

Response to the Letter to the Editor Entitled "Atypical anti-GBM disease: A Case for the Occam's Razor? [PDF]

Kidney Int Rep
Fernández-Lorente L, Mora-Gutiérrez JM.   +1 more
europepmc   +1 more source

Ensemble Modeling of Shifts in the Suitable Distribution and Ecological Niche of the Alpine Tibetan Medicinal Herb Corydalis hendersonii Hemsl. Under Climate Change and Human Activity

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Corydalis hendersonii, a rare alpine Tibetan medicinal herb, faces increasing threats from climate warming and intensified human activity. Using a biomod2 ensemble species distribution model that integrates climate variables and the Human Footprint Index, we predict that suitable habitats will remain stable or slightly expand under SSP126 but contract ...
Dehua Wu, Yanlei Liu, Zhixian Jing, Siqi Liu, Ba Qiang, Weiwu Chen, Yiheng Wang, Chuanzhi Kang, Zekun Zhang   +8 more
wiley   +1 more source

Concurrent anti-GBM disease and p-ANCA vasculitis presenting as pulmonary-renal syndrome in a patient with chronic kidney disease: a case report. [PDF]

Ann Med Surg (Lond)
Nazeer R, Nazir MA, Singla B, Singla S, Mazari S.   +4 more
europepmc   +1 more source

Anti-GBM Disease Following Ovarian Mesonephric-Like Adenocarcinoma: A Unique Insight Into Paraneoplastic Autoimmunity. [PDF]

Kidney Med
Fairhead T, Seager S, Whitehead J, Fenwick S.   +3 more
europepmc   +1 more source

Beyond Glycolysis: Targeting Non‐Glycolytic Metabolic Pathways in Brain Tumors for Therapeutic Innovation: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic reprogramming is a hallmark of brain tumors, extending beyond the classical Warburg effect. While glycolysis has been extensively studied, gliomas and pediatric high‐grade brain cancers demonstrate remarkable metabolic plasticity.
Iffat Islam Mayesha, Zubaier Ahmed, Ammarah Laaika Mohiuddin, Faiza Fairuz Muskan, Saiful Islam, Sharmin Jahan Sumaya   +5 more
wiley   +1 more source

Integrative Bioinformatics Analysis Reveals COL13A1 and COL23A1 as Potential Diagnostic and Prognostic Biomarkers in Thyroid Cancer

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer.
Md. Wahidul Islam, Md. Minhajur Rahman, Homaira Naznin, Md. Shohel Hossain, Tahmina Akter, Zayeda Akter Shatabde, Md. Jubayer Hossain   +6 more
wiley   +1 more source

Renal-Limited Anti-GBM Disease in Dual-Antibody Positive RPGN: A Case Report. [PDF]

J Brown Hosp Med
Guo W, O'Donnell M.
europepmc   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source