Results 151 to 160 of about 6,619,911 (229)

Association of Neutrophil Percentage‐to‐Albumin Ratio (NPAR) With Pathological Features and Long‐Term Prognosis in Diabetic Kidney Disease: A Cohort Study

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
This graphical abstract summarizes the association between the neutrophil percentage‐to‐albumin ratio (NPAR), renal pathology, and prognosis in biopsy‐confirmed diabetic kidney disease. Higher NPAR was associated with increased renal MPO‐positive neutrophil infiltration, more severe histopathological injury, and poorer renal outcomes.
Yang Li, Hongyu Wang, Wendi He, Yi Fang, Shi Jin, Hong Liu, Jie Li, Nana Song, Xiaoqiang Ding, Yan Dai   +9 more
wiley   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives. [PDF]

Brain Behav
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Zehravi M, Hassan MA, Amin MA, Sweilam SH, Gupta JK, Babu RH, Raju PVN, Kandimalla KV, Erukulla P, Jahnavi P, Vodeti R, Billah AAM, Rab SO, Khan SL.   +13 more
europepmc   +2 more sources

Antipsychotic Drug Interactions and Short‐Term Mortality Risk in People With Dementia: A National Cohort Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1081-1091, October 2026.
Antipsychotics are often prescribed in the management of behaviors and psychological symptoms of dementia. While the potential harms of antipsychotic use in people with dementia have been established, little is known about the risk associated with antipsychotic drug–drug interactions (DDIs). This study aims to examine the patterns of antipsychotic DDIs
Edward C.Y. Lau, Grace H. Shim, Chin Hang Yiu, Sarah N. Hilmer, Yun‐Hee Jeon, Weisi Chen, Christine Y. Lu, Edwin C.K. Tan   +7 more
wiley   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

The multiple autoantibodies in anti-GBM disease. [PDF]

Nephrol Dial Transplant
Prendecki M, Pusey CD.
europepmc   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

Response to the Letter to the Editor Entitled "Atypical anti-GBM disease: A Case for the Occam's Razor? [PDF]

Kidney Int Rep
Fernández-Lorente L, Mora-Gutiérrez JM.   +1 more
europepmc   +1 more source

Surface‐Enhanced Raman Scattering‐Based Multimodal Medical Imaging in Cancer Diagnosis and Therapy Monitoring

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT Surface‐enhanced Raman scattering (SERS) has emerged as a highly sensitive and specific technique for tumor imaging, owing to its narrow spectral features, resistance to photobleaching, and capability for multiplexed detection. However, its clinical translation remains limited by poor tissue penetration and the absence of intrinsic anatomical ...
Xinyu Miao, Yujiao Xie, Aochi Liu, Shishuai Zheng, Dong Xu, Aiguo Wu, Jie Lin, Xiaoxia Wu   +7 more
wiley   +1 more source