Results 161 to 170 of about 89,994 (247)

Outcomes and salvage strategies for large B‐cell lymphoma progressing after second‐line CAR T‐cell therapy: A DESCAR‐T study from the LYSA group

HemaSphere, Volume 10, Issue 5, May 2026.
Abstract Relapse after chimeric antigen receptor (CAR) T‐cell therapy in large B‐cell lymphoma (LBCL) is associated with a dismal prognosis. Although Phase 3 trials have established CAR T‐cells as standard second‐line (2L) therapy, outcomes and optimal management after relapse in this setting remain unknown because no real‐world data are currently ...
Pierre Sesques, Guillaume Manson, Guillaume Cartron, François‐Xavier Gros, Franck Morschhauser, Cristina Castilla‐Llorente, Gabriel Brisou, Pierre Bories, Catherine Thieblemont, Laurianne Drieu La Rochelle, Benoit Tessoulin, Axel André, Cedric Rossi, Jérôme Paillassa, Stephanie Guidez, Antoine Capes, Laura Herbreteau, Sylvain Choquet, Jacques‐Olivier Bay, Adrien Chauchet, Laure Lebras, Fabien Claves, Julie Abraham, Jean‐Valère Malfuson, Marie‐Thérèse Rubio, Justine Decroocq, Luc‐Matthieu Fornecker, Gandhi Damaj, Ludovic Fouillet, Magalie Joris, Michael Loschi, Olivier Hermine, Hadia Hafirassou, Emelie Van Zele, Vivien Dupont, Steven Le Gouill, Roch Houot, Vincent Camus   +37 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Two Cases of Diffuse Alveolar Haemorrhage Attributable to Human Metapneumovirus Infection: A Case Report

Respirology Case Reports, Volume 14, Issue 5, May 2026.
We report two cases of diffuse alveolar haemorrhage attributable to human metapneumovirus (hMPV), confirmed by PCR analysis of bronchoalveolar lavage fluid. Although the precise efficacy remains uncertain, both cases showed clinical improvement following short‐term corticosteroid therapy.
Masamichi Lee, Junji Takiguchi, Yuu Kobayashi, Yoshihiko Tanimoto, Ai Mori, Hiromi Tomioka   +5 more
wiley   +1 more source

Comorbid Alzheimer's Disease and Type 2 Diabetes Microbiota Shape Age‐Associated Gut–Brain Axis Profiles

Aging Cell, Volume 25, Issue 5, May 2026.
Fecal microbiota transplantation from elderly donors with Alzheimer's disease, type 2 diabetes, or both conditions into antibiotic‐treated mice revealed that comorbid microbiota produce the most severe dysbiosis and strongest suppression of hippocampal neurotrophic gene expression.
Alessandro Atzeni, Jonas Mingaila, Gediminas Alzbutas, Rokas Lukoševičius, Justinas Drūteika, Kamila Łuczyńska, Rima Ramonaitė, Tadeusz Pietras, Kasper Sipowicz, Dovilė Kiudelytė, Karolina Keršytė, Emilija Keževičiūtė, Greta Najūtė, Juozas Kupčinskas, Jordi Mayneris‐Perxachs, Daiva Baltriukienė, Aurelijus Burokas   +16 more
wiley   +1 more source

The Overlooked Autoantibody Repertoire: Exploring the Biomarker Potential of Downregulated Autoantibodies in NSCLC

Cancer Science, Volume 117, Issue 5, Page 1244-1259, May 2026.
This study identifies downregulated autoantibodies in NSCLC and demonstrates their diagnostic and prognostic utility. Integrating proteome‐wide screening and large‐cohort validation, we highlight a novel biomarker class that enhances early detection and patient stratification.
Yihao Liang, Hanke Ma, Wenke Sun, Ying Chen, Fengqi Chen, Yutong Li, Songyun Ouyang, Liping Dai   +7 more
wiley   +1 more source

L1CAM Promotes the Infiltrative Properties of Patient‐Derived Glioblastoma Cells

Cancer Science, Volume 117, Issue 5, Page 1380-1396, May 2026.
In vivo validation of L1CAM‐mediated GBM infiltration. Orthotopic transplantation of L1CAM‐expressing GBM cells into mouse brains demonstrated that L1CAM significantly promotes tumor cell infiltration and expansion in the brain parenchyma, confirming its critical role in the aggressive progression of GBM.
Asako Katsuma, Daisuke Kanematsu, Yukako Handa, Tomoko Shofuda, Atsuyo Yamamoto, Kayo Nishitani, Zhize Xiao, Daisuke Kawauchi, Kentarou Baba, Naoyuki Inagaki, Yonehiro Kanemura   +10 more
wiley   +1 more source

Predicting Pressure Injury Prevention Education by Acute Care Nurses Within 24 h of Hospital Admission: A Cross‐Sectional Study

Journal of Advanced Nursing, Volume 82, Issue 5, Page 5036-5048, May 2026.
ABSTRACT Aim Predicting medical/surgical nurses' delivery of patient pressure injury prevention education within 24 h of hospitalisation. Design A cross‐sectional sub‐study drawn from a larger multisite randomised controlled trial. Methods A consecutive sub‐sample of 300 randomly assigned control group participants was recruited from 20 medical and ...
Jodie Lee Deakin, Sharon Leanne Latimer, Rachel M. Walker, Brett Dyer, Brigid Mary Gillespie   +4 more
wiley   +1 more source

World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs [PDF]

, 2015
Aresu, L, Brovida, C, Brown, C A, Cianciolo, R E, Cowgill, L D, Heiene, R, James, C, Jansen, J H, Kass, PH, Lees, G E, Mohr, F C, Polzin, D J, Spangler, W L, Syme, H M, Vaden, S L, van de Lugt, JJ, van Dongen, A M   +16 more
core   +2 more sources

Clinical significance of renal histological diagnosis in patients with type 2 diabetes and proteinuria atypical for diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 781-790, May 2026.
ABSTRACT Background/Aim Most patients with proteinuria are considered to have typical diabetic nephropathy (DN). However, when proteinuria occurs without diabetic retinopathy, with hematuria, or persists despite strict glycemic and blood pressure control, it is considered atypical for DN and warrants further evaluation for non‐DN via kidney biopsy ...
Shogo Kuwagata, Masami Chin‐Kanasaki, Aki Yamada, Tomonori Sakae, Nahomi Ishimoto, Yoshimi Imamura‐Uehara, Kosuke Yamahara, Mako Yasuda‐Yamahara, Sho Sugahara, Yuki Tanaka‐Sasaki, Natsumi Kuwata, Kimihiro Nishimura, Koichiro Murata, Itsuko Miyazawa, Shogo Ida, Natsuko Ohashi, Shinji Kume   +16 more
wiley   +1 more source

Anti-GBM Disease Following Ovarian Mesonephric-Like Adenocarcinoma: A Unique Insight Into Paraneoplastic Autoimmunity. [PDF]

Kidney Med
Fairhead T, Seager S, Whitehead J, Fenwick S.   +3 more
europepmc   +1 more source