Results 141 to 150 of about 89,994 (247)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Bowman’s capsule rupture and its clinical significance in patients with anti-glomerular basement membrane disease

Frontiers in Immunology
BackgroundAnti-glomerular basement membrane (GBM) disease represents the most severe form of crescentic glomerulonephritis. Previous studies demonstrated that Bowman’s capsule rupture contributed to the progression of crescentic glomerulonephritis ...
Huang Kuang, Huang Kuang, Huang Kuang, Huang Kuang, Cai-xia Lin, Cai-xia Lin, Cai-xia Lin, Cai-xia Lin, Xiao-juan Yu, Xiao-juan Yu, Xiao-juan Yu, Xiao-juan Yu, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia   +23 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. [PDF]

, 2018
Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and ...
GLASS Consortium
core  

Glomerular plasmalemma vesicle‐associated protein‐1 as an endothelial remodelling marker complementing C4d in chronic active antibody‐mediated rejection

Histopathology, EarlyView.
Glomerular plasmalemma vesicle‐associated protein‐1 (PV‐1/PLVAP) identifies dynamic endothelial remodelling in chronic active antibody‐mediated rejection (caABMR), complementing glomerular C4d, which reflects a static footprint of complement activation. Combined assessment of PV‐1 and C4d captures complementary dimensions of microvascular pathology and
Yuto Igarashi, Mayu Shimokawa, Kunio Kawanishi, Toshihito Hirai, Hiroshi Seino, Tomokazu Shimizu, Hideki Ishida, Toshio Takagi   +7 more
wiley   +1 more source

IgA Nephropathy and Atypical Anti-GBM Disease: A Rare Dual Pathology in a Pediatric Rapidly Progressive Glomerulonephritis. [PDF]

Glomerular Dis, 2022
Bajaj V, Thakur S, Barwad A, Sinha A, Bagga A, Singh G.   +5 more
europepmc   +1 more source

Glioblastoma mimicking anti‐NMDA receptor encephalitis: a case series

Internal Medicine Journal, EarlyView.
Abstract Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) GluN1‐IgG antibodies are the hallmark of anti‐NMDAR encephalitis, a common type of autoimmune encephalitis. We describe two men with seizures and asymmetric, mass‐like temporal lesions initially treated as anti‐NMDAR encephalitis: Case 1 had serum and cerebrospinal fluid (CSF) NMDAR‐IgG ...
Sophie Chatterton, Fangzhi (Frank) Jia, Antonia J. Clarke, Laveniya Satgunaseelan, Hwei Choo Soh, Karl Ng, Kaitlyn Parratt, John Parratt   +7 more
wiley   +1 more source

Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease. [PDF]

J Am Soc Nephrol, 2021
Shen CR, Jia XY, Luo W, Olaru F, Cui Z, Zhao MH, Borza DB, Borza DB.   +7 more
europepmc   +1 more source

Application of Thermoresponsive Polymer and Microfluidics to the Development of a Velocity-Dependent Cell-Sorting Microdevice [PDF]

, 2018
3rd Place, Denman Undergraduate Research ForumLow-cost velocity dependent cell sorting in 2D is a currently nonexistent technology for cancer research. The development of such a device would enable further research on the treatment of various deleterious
Fine, Jesse
core  

Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang, Chung‐I Li, Rui Xin, Jijun Tang, Yan Guo   +4 more
wiley   +1 more source