Results 111 to 120 of about 74,969 (210)
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim +22 more
wiley +1 more source
BackgroundAnti-glomerular basement membrane (GBM) disease represents the most severe form of crescentic glomerulonephritis. Previous studies demonstrated that Bowman’s capsule rupture contributed to the progression of crescentic glomerulonephritis ...
Huang Kuang +23 more
doaj +1 more source
Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects
Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang +5 more
wiley +1 more source
Introduction: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune vasculitis that often leads to rapidly progressive glomerulonephritis and poor renal prognosis.
Cheng Xue +7 more
doaj +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Relapse of treated anti-GBM disease following hair dye use. [PDF]
Povey J +3 more
europepmc +1 more source
Cancer heterogeneity explored through immune cell deconvolution of the tumor microenvironment
Abstract Cancer is a highly heterogeneous disease, characterized by significant variability across multiple dimensions. This diversity has been extensively studied from various perspectives. In this study, we aim to examine cancer heterogeneity through the lens of immune cell composition within the tumor microenvironment.
Limin Jiang +4 more
wiley +1 more source
IgA Nephropathy and Atypical Anti-GBM Disease: A Rare Dual Pathology in a Pediatric Rapidly Progressive Glomerulonephritis. [PDF]
Bajaj V +5 more
europepmc +1 more source
Syntaxin 12 Sustains Endosomal‐Lysosomal Homeostasis and Survival in Glioblastoma Stem‐Like Cells
Syntaxin12 maintains endolysosomal trafficking and lysosomal homeostasis in glioblastoma cells. Syntaxin12 depletion disrupts lysosomal organization, impairs endolysosomal progression and mTOR‐lysosome communication, and compromises adaptive pathways required for cell survival. ABSTRACT Glioblastoma cells display a striking vulnerability to disruptions
Clément Maghe +7 more
wiley +1 more source
Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease. [PDF]
Shen CR +7 more
europepmc +1 more source

