Results 111 to 120 of about 89,994 (247)

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Clinical Performance of a Novel, Fully Automated Multiplexed Immunoassay for the Simultaneous Detection of Anti-PR3, Anti-MPO, and Anti-GBM Autoantibodies in ANCA-Associated Vasculitis and Anti-GBM Disease

Journal of Clinical Rheumatology and Immunology
Background: Accurate and timely detection of anti-neutrophil cytoplasmic antibodies (ANCA)—specifically against myeloperoxidase (MPO) and proteinase 3 (PR3)—as well as antibodies to glomerular basement membrane (GBM), is critical in the diagnosis of ...
Jason Sillitoe, Caroline Wilson, Ewa Garyga, Pedro Silva, Kristiana Nita, Ewa Fiorentino-Rozek, Jose Santiago, Gerber Gomez, Christian Fischer, John Tyson, Makoto Miyara   +10 more
doaj   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, EarlyView.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease

Glomerular Diseases
Introduction: Concurrent atypical anti-glomerular basement membrane (anti-GBM) disease with membranous nephropathy is a rare occurrence. Compared to typical anti-GBM disease, atypical anti-GBM disease is often seronegative, with a mild disease
Renuka Tolani, Steffi Sathiyaraj, David Lyu, Luan Truong, Theresa Thurston, Ziad M. El-Zaatari, Ali R. Khan, Angelina Edwards, Shane A. Bobart   +8 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1 [PDF]

, 2016
Background MicroRNA-129-1 (miR-129-1) seems to behave as a tumour suppressor since its decreased expression is associated with different tumours such as glioblastoma multiforme (GBM).
Ali Hosseini Rad, S.M., Fathi-Roudsari, M., Hajarizadeh, A., Hanif, H., Keramati, F., Kouhkan, F., Lahmi, R., Mobarra, N., Soleimani, M., Soufi-Zomorrod, M., Tavakoli, R., Ziaei, S.   +11 more
core  

A Stacked Ensemble Multi‐Label Model for Predicting Co‐Occurring Microvascular and Macrovascular Complications in Type 2 Diabetes

Chronic Diseases and Translational Medicine, EarlyView.
Feature importance for predicting multiple diabetes complications based on a Stacking‐Classifier Chain model. Abstract Background Type 2 diabetes mellitus (T2DM) leads to severe microvascular and macrovascular complications. Traditional single‐label prediction models fail to capture their co‐occurring nature.
Maryam Zamani, Maryam Farhadian, Nasrin Piran, Shiva Borzouei   +3 more
wiley   +1 more source

Granular Immunofluorescence deposition of IgG in anti-GBM antibody disease

Pan African Medical Journal, 2014
Our patient was a 75 year old male, who presented with worsening dysphagia for solids and liquids and increasing malaise. His past medical history was significant for Chronic Obstructive Pulmonary Disease (COPD), Coronary Artery Disease (CAD) and Peripheral Vascular Disease (PVD).
Syed Amer, Mohammed Muqeetadnan
openaire   +3 more sources

Living Microbial Drugs

Chemistry – A European Journal, EarlyView.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik, Nazlıcan Tunç, Senem Şen, Urartu Özgür Şafak Şeker   +3 more
wiley   +1 more source

Falsely positive anti-glomerular basement membrane antibodies in a patient with hantavirus induced acute kidney injury - a case report

BMC Nephrology, 2018
Background Hantavirus infection is an uncommon cause of acute renal failure with massive proteinuria. Serology tests to support a presumptive diagnosis usually take a few days.
H. W. Zijlstra, A. H. L. Mulder, F. Geeraedts, F. Visser   +3 more
doaj   +1 more source