Long-term outcome of anti-glomerular basement membrane antibody disease treated with immunoadsorption. [PDF]
PLoS ONE, 2014 Anti-glomerular basement membrane (GBM) antibody disease may lead to acute crescentic glomerulonephritis with poor renal prognosis. Current therapy favours plasma exchange (PE) for removal of pathogenic antibodies.
Peter Biesenbach +8 more
doaj +1 more source
Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors [PDF]
, 2018 Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Hallahan, Dennis +7 more
core +2 more sources
The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
core +1 more source
Case Reports in Nephrology, 2023 Antiglomerular basement membrane disease (anti-GBM) is an unusual cause of glomerulonephritis. Patients usually present with rapidly progressive glomerulonephritis with or without pulmonary hemorrhage.
Areerat Ounhasuttiyanon +2 more
doaj +1 more source
Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]
, 2013 As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines +4 more
core +3 more sources
The Immunobiological Agents for Treatment of Antiglomerular Basement Membrane Disease
Medicina, 2023 Combination therapy with glucocorticoids, cyclophosphamide, and plasmapheresis is recommended as the standard treatment for anti-glomerular basement membrane (anti-GBM) disease, but the prognosis of this disease remains poor.
Marina Yamashita +3 more
doaj +1 more source
Retransplantation in Alport post-transplant anti-GBM disease [PDF]
Kidney International, 2004 Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies. Gene deletions are more commonly associated with this complication than are point mutations.
Browne, Gemma +8 more
openaire +3 more sources
Renal Failure, 2021 Introduction Extracorporeal shock wave lithotripsy (ESWL) is a noninvasive modality to treat urolithiasis, with complications including tissue damage and hematoma of kidney parenchyma.
Beining Wang +4 more
doaj +1 more source
The small molecule ephrin receptor inhibitor, GLPG1790, Reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma models [PDF]
, 2019 Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
Beirinckx, Filip +15 more
core +2 more sources
Renal Failure, 2021 Introduction Anti-glomerular basement membrane (anti-GBM) disease is a small vessel vasculitis affecting the renal and lung capillary beds. We aim to study the clinicopathological characteristics and predictors of poor outcome of this disease in our ...
Zafirah Zahir +3 more
doaj +1 more source