Results 131 to 140 of about 312,758 (261)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

New Advances in Anti-HIV-1 Strategies Targeting the Assembly and Stability of Capsid Protein. [PDF]

Int J Mol Sci
Zhang C, Li B, Li J, Zhang H, Wu Y.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

J3ExoA: A Novel Anti-HIV Immunotoxin Fusion of Anti-Gp120 J3VHH and PE38 Fragment of <i>Pseudomonas</i> Exotoxin A. [PDF]

Pharmaceuticals (Basel)
Pincus SH, Luo K, Peters T, Gordy JT, Cole FM, Klug G, Ober K, Marcotte TK, Markham RB.   +8 more
europepmc   +1 more source

Clinical guideline highlights for the hospitalist: Updates on the treatment of drug‐susceptible and drug‐resistant tuberculosis

Journal of Hospital Medicine, EarlyView.
Allison Stickles, Anna Poston‐Blahnik, Elizabeth Schlaudecker, Moises Huaman   +3 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

CD4-Based Chimeric Antigen Receptor (CAR)-T Cells With Resistance to HIV-1 Infection and Enhanced Anti-HIV Efficacy: Covalent Interaction Between CD4-CAR and HIV-1 Envelope Glycoprotein. [PDF]

J Med Virol
Lou Y, He X, Li G, Sikhondze M, Ma J, Du H, Ouyang X, Dotti G, Sajadi M, Su L.   +9 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Anti-HIV Activity of Tigliane Derivatives from <i>Euphorbia nicaeensis</i> Roots. [PDF]

Molecules
Krstić G, Jadranin M, Schols D, Claes S, Tešević V, Mandić B, Milosavljević S, Wittine K.   +7 more
europepmc   +1 more source

The Mexico City Policy in US Development Policy and Its Backlash‐Frontlash‐Logic

Public Administration and Development, EarlyView.
ABSTRACT The Mexico City Policy provides for the discontinuation of U.S. government funding for foreign non‐governmental organizations (NGOs) that provide legal abortion services. While Republican administrations have repeatedly pushed for the introduction of the Mexico City Policy after their re‐election, those regulations have been rescinded by ...
Thomas Lange
wiley   +1 more source