Results 151 to 160 of about 312,758 (261)

The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype

Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli, Christelle Nilles, Gerald Pfeffer, Matthew Joel, Davide Martino   +4 more
wiley   +1 more source

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

Phytotherapy Research, EarlyView.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf, Ayfer Busra Benkli, Ramiz Yusuf   +2 more
wiley   +1 more source

CD24-Fc resolves inflammation and enhances anti-HIV CD8 T cells with polyfunctionality during HIV-1 infection under cART. [PDF]

PLoS Pathog
Li G, Ma J, Yu H, Tsahouridis O, Lou Y, He X, Funaki M, Zheng P, Liu Y, Su L.   +9 more
europepmc   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Pharmacokinetics Analysis of Serum and Rectal Tissue Concentrations of a Pair of Anti-HIV Monoclonal Antibodies, VRC01 and VRC01LS, in Adults Without HIV. [PDF]

J Clin Pharmacol
Huang Y, Zhang L, Lemos MP, Astronomo RD, Narpala S, Prabhakaran M, Garcia NMG, Lu Y, Mize GJ, Glantz H, Colegrove H, Mann P, Paez CA, Andersen-Nissen E, Hutter J, Dumond J, McDermott AB, Mascola JR, Koup RA, Bekker LG, McElrath MJ.   +20 more
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Synthesis, Characterisation, Biological Evaluation and In Silico Studies of Quinoline-1,2,3-Triazole-Anilines as Potential Antitubercular and Anti-HIV Agents. [PDF]

Molecules
Magwaza SS, Naidu D, Oyeneyin OE, Senzani S, Mkhwanazi NP, Tukulula M.   +5 more
europepmc   +1 more source

Goffman's Tempting the Devil in Stigma: A Close Rereading of Goffman's “Subversive” Construct of “the Normals” Versus “the Stigmatized”

Symbolic Interaction, EarlyView.
This article engages in a close rereading of Stigma, relating it to Goffman's biography as a person who faced stigma. Exploring his biography helps us to recognize the ways Goffman applies stigma strategies in how he represents himself as the author in Stigma.
Thaddeus Müller
wiley   +1 more source

An Anti-HIV Drug Is Highly Effective Against SARS-CoV-2 In Vitro and Has Potential Benefit for Long COVID Treatment. [PDF]

Viruses
Khaidarov S, Hejran AB, Moldakaryzova A, Izmailova S, Nurgaliyeva B, Beisenova A, Mustafaeva A, Nurzhanova K, Belova Y, Satbayeva E, Aidarov A, Ossikbayeva S, Kukubassov Y, Amankulov J, Goncharova T, Yeszhan B, Tulman E, Tazhibayeva KN, Sadykova A, Kozhabergenov N, Burashev Y.   +20 more
europepmc   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source