Viruses, 2022 HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) area key component of the current HIV-1 combination drug regimens. Although they exhibit potent anti-HIV-1 activity and modest toxicity, the emergence of mutant strains limits their ...
Dongwei Kang +12 more
doaj +1 more source
Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom [PDF]
, 2001 Objectives: To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom. Design: Retrospective and prospective assessment of viruses obtained from people recently infected with HIV.
Baily, Guy +7 more
core +2 more sources
Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end [PDF]
, 2014 Novel conjugated G-quadruplex-forming d(TG3AG) oligonucleotides, linked to hydrophobic groups through phosphodiester bonds at 50-end, have been synthesized as potential anti-HIV aptamers, via a fully automated, online phosphoramidite-based solid-phase ...
Balzarini, J. +10 more
core +1 more source
Swiss Medical Weekly, 2001 Highly active antiretroviral therapies (HAART), usually consisting of two nucleoside reverse transcriptase inhibitors (NRTI) plus an HIV protease inhibitor (PI), have been widely used since 1996. They produce durable suppression of viral replication with undetectable plasma levels of HIV-RNA in more than half of patients.
Flepp, Markus +3 more
openaire +4 more sources
Anti-HIV seropositivity among different group of patients; an observation from a secondary medical center in an endemic area of HIV infection [PDF]
Journal of Preventive Epidemiology, 2019 Human immunodeficiency virus (HIV) infection is an important medical problem worldwide. Since there is still no curative treatment, the good management for the HIV infected patient is necessary.
Pathum Sookaromdee, Viroj Wiwanitkit
doaj
Novel Antiretroviral Structures from Marine Organisms
Molecules, 2019 In spite of significant advancements and success in antiretroviral therapies directed against HIV infection, there is no cure for HIV, which scan persist in a human body in its latent form and become reactivated under favorable conditions.
Karlo Wittine +3 more
doaj +1 more source
Biological evaluation and molecular modelling of didanosine derivatives [PDF]
, 2014 Five carbonate derivatives of 50-O-20,30-dideoxyinosine (DDI, 1) have been synthesized by combination with aliphatic alcohols, with their in vitro anti-HIV activity and cytotoxicity being evaluated afterward in human peripheral blood mononuclear cells ...
Briñon, Margarita Cristina +6 more
core +1 more source
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. [PDF]
PLoS ONE, 2014 The aim of this study is to explore the prevalence of hepatitis C virus (HCV) infection among injection drug users (IDUs) with and without human immunodeficiency virus (HIV) infection in southern Taiwan.
Meng-Hsuan Hsieh +13 more
doaj +1 more source
Anti-HIV drugs and the mitochondria
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Several drugs are currently used that can significantly prolong the course of the infection with the human immunodeficiency virus (HIV), the cause of the acquired immunodeficiency syndrome (AIDS). Among these drugs, the nucleosidic inhibitors of viral reverse transcriptase can alter mitochondrial (mt) function by inhibiting the mitochondrial DNA ...
PINTI, Marcello +2 more
openaire +3 more sources
Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies. [PDF]
PLoS ONE, 2010 We investigated the impact of antimicrobials in cervicovaginal lavage (CVL) from HIV(+) and HIV(-) women on target cell infection with HIV. Since female reproductive tract (FRT) secretions contain a spectrum of antimicrobials, we hypothesized that CVL ...
Mimi Ghosh +10 more
doaj +1 more source