Results 291 to 300 of about 686,239 (385)

New anti‐HIV agents and targets

Medicinal Research Reviews, 2002
AbstractVirtually all the compounds that are currently used or are subject of advanced clinical trials for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside reverse transcriptase inhibitors (NRTIs): i.e., zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine and nucleotide reverse ...
E. Clercq
openaire   +3 more sources

Rationally Designed Multitarget Anti-HIV Agents

Current Medicinal Chemistry, 2013
Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as improving patient compliance.
P, Zhan, X, Liu
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Therapeutic potential of indole derivatives as anti-HIV agents: A mini-review.

Current Topics in Medicinal Chemistry, 2021
Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is one of the leading causes of human deaths. The advent of different anti-HIV drugs over different disease progress has made AIDS/HIV from a deadly infection to ...
Qingtai Chen, Chongchong Wu, Jinjin Zhu, Enzhong Li, Zhi Xu   +4 more
semanticscholar   +1 more source

Alkaloids as Potential Anti-HIV Agents

Current HIV Research, 2023
Background: Alkaloids are nitrogen-containing compounds that are naturally occurring and have a variety of biological activities, including antimicrobial properties. In this study, the authors used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids.
Nidhi, Rani, Randhir, Singh, Praveen, Kumar, Prerna, Sharma, Rajwinder, Kaur, Rashmi, Arora, Thakur Gurjeet, Singh   +6 more
openaire   +2 more sources

A Review on Quinoline Derived Scaffolds as Anti-HIV Agents.

Mini-Reviews in Medical Chemistry, 2019
After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS).
Nisha Chokkar, Sourav Kalra, M. Chauhan, Raj Kumar   +3 more
semanticscholar   +1 more source

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking.

Medicinal chemistry, 2019
BACKGROUND Human immunodeficiency virus (HIV) is an infective agent that causes an acquired immunodeficiency syndrome (AIDS). Therefore, the rational design of inhibitors for preventing the progression of the disease is required.
A. Worachartcheewan, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul, C. Nantasenamat, V. Prachayasittikul   +5 more
semanticscholar   +1 more source

Quinobene, a new potent anti-HIV agent

Biochemical and Biophysical Research Communications, 1992
A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound.
E, Gruszecka-Kowalik, R D, Haugwitz, L H, Zalkow   +2 more
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DNA aptamers as potential anti-HIV agents

Trends in Biochemical Sciences, 2005
Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in
Shan-Ho, Chou, Ko-Hsin, Chin, Andrew H-J, Wang   +2 more
openaire   +2 more sources

6-Aminoquinolones as New Potential Anti-HIV Agents

Journal of Medicinal Chemistry, 2000
A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human ...
V. CECCHETTI, PAROLIN, MARIA CRISTINA, MORO, STEFANO, PECERE T., E. FILIPPONI, CALISTRI, ARIANNA, O. TABARRINI, GATTO, BARBARA, PALUMBO, MANLIO, A. FRAVOLINI, PALU', GIORGIO   +10 more
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Combinatorial Synthesis of anti‐HIV Agents

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Dharmarajan Sriram, Perumal Yogeeswari, Ananantha Naik Nagappa   +2 more
openaire   +1 more source