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Natural Products as Anti- HIV Agents
Nigerian Quarterly Journal of Hospital Medicine, 2008Acquired immunodeficiency syndrome (AIDS) is a pandemic immunodegenerative disease caused by human immunodeficiency virus (HIV). The disease is ravaging, given the number of patients infected with the disease worldwide, the high mortality rate and attendant socio-economic casualties in affected countries, mostly in Africa.
Adesegun, S A, Ajayi, G O, Coker, H A
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Repurposing Phytochemicals as Anti-HIV Agents
Journal of Antivirals & Antiretrovirals, 2016Phytochemicals play crucial role in inhibiting key enzymes involved in HIV-1 replication. Repurposing of phytochemical based anti-HIV drug discovery through cross screening approaches and modern techniques is essential to provide better leads. Anti-HIV leads translated through phytochemicals could overcome current challenges of HIV therapy. Considering
Pratiksha Jadaun +2 more
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Nihon rinsho. Japanese journal of clinical medicine, 2012
Since the introduction of zidovudine into HIV clinical practice in 1985, the history of antiretroviral treatment has been started. Even in well controlled patients with HIV loads under the detection limit for many years, viral load rebound could occur followed by CD4 cell count decline, if the antiretroviral treatment is interrupted.
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Since the introduction of zidovudine into HIV clinical practice in 1985, the history of antiretroviral treatment has been started. Even in well controlled patients with HIV loads under the detection limit for many years, viral load rebound could occur followed by CD4 cell count decline, if the antiretroviral treatment is interrupted.
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Natural Products as Anti-HIV Agents
1992The publication, in 1981, of a report announcing the occurrence of a cluster of diagnoses of a rare form of pneumonia due to the microorganism Pneumocystis carinii in a group of male homosexuals in San Francisco constitutes the first notice of the advent of a new disease. It was quickly recognized, subsequent to that report, that the occurrence of this
Daniel Lednicer, Ven L. Narayanan
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Researchers Explore New Anti-HIV Agents
JAMA, 2002SEATTLE—While antiretroviral drugs have done much to extend the lives of people infected with HIV, severe adverse effects and rising levels of drug resistance can limit their usefulness and are driving efforts to develop new antiHIV medications. Building on knowledge of HIV gleaned from laboratory studies of the virus, researchers are developing and ...
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Antisense Oligonucleotide as Anti-HIV Agents.
Kobunshi, 1993アンチセンスRNA/DNAを利用した医薬品開発の一つとして,エイズの原因であるHIVの感染,増殖抑制作用をもつオリゴマーの合成とin vitro試験での活性評価を行った.結果,rev,tat遺伝子に相補的なphosphorothioate型オリゴDNAが強い抗HIV活性を示すことを確認した.今後,詳細な作用機序や代謝機構が明確にされることで,治療薬としての位置付けが確立されるであろう.
Hideki Nakashima, Naoki Yamamoto
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