Results 81 to 90 of about 927,052 (258)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Targeting IL-23: Insights into the pathogenesis and the treatment of psoriasis

Indian Journal of Dermatology, 2010
Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis.
Lima Hermenio, Kimball Alexandra
doaj  

IFN-γ and IL-17 elicit synergistic anti-mycobacterial responses by inhibiting coronin-1A retention

Communications Biology
CD4+IFN-γ+IL-17+ T cells and their secreted cytokines play a critical role in the anti-mycobacterial response. However, the underlying synergistic mechanism of IFN-γ and IL-17 is little known. This study demonstrates that the downregulation of coronin-1A
Hye-Soo Park, Thuy An Pham, ZongYou Jiang, Seunga Choi, Yong Woo Back, In-Taek Jang, Ki Won Shin, Yeo-Jin Son, Han-Gyu Choi, Hwa-Jung Kim   +9 more
doaj   +1 more source

IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model

Frontiers in Immunology
Smoking remains the main risk factor for the development of chronic obstructive pulmonary disease (COPD). The inflammatory response mediated by innate and adaptive immune cells has been described in the development and progression of the disease, and the
Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Fernanda Degobbi Tenorio Quirino dos Santos Lopes   +14 more
doaj   +1 more source

Paradoxical Reactions to Anti-TNFα and Anti-IL-17 Treatment in Psoriasis Patients: Are Skin and/or Gut Microbiota Involved? [PDF]

Dermatol Ther (Heidelb), 2023
Jiraskova Zakostelska Z, Reiss Z, Tlaskalova-Hogenova H, Rob F.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Macrophage polarization induced immune dysregulation in rheumatoid arthritis

Zanco Journal of Medical Sciences
Background and objective: Rheumatoid arthritis (RA) is one of the most prominent inflammatory autoimmune illnesses, causing polyarticular synovitis. The precise causes of RA are still unknown; however, chronic inflammation patterns are influenced by a ...
Rezan Mahmood Kaka Sur, Ramiar Kamal Kheder   +1 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Cytokine Profiles in Rheumatoid Arthritis: Relationship of TNF-α , IL-17, and IL-13 with Autoantibodies (RF and Anti-CCP) and Clinical Disease Severity

مجلة بغداد للعلوم
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and autoantibody production. This study aimed to assess serum levels of TNF-α , IL-17, and IL-13 in RA patients and to explore their association with disease
Sonia Elia Ishaq, Taban Kamal Rasheed, Niaz Albarzingi   +2 more
doaj   +1 more source