Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088. [PDF]
Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab fragment revealed an unusual noncanonical conformation of CDR L1. Most antibodies with the kappa light chain exhibit a canonical structure for CDR L1 in which residue 29 anchors the CDR loop to the framework.
Teplyakov A +3 more
europepmc +4 more sources
Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases. [PDF]
Cancer Research, 2014 Tumor-induced immunosuppression remains one of the major obstacles to many potentially effective cancer therapies and vaccines. Host interleukin (IL)-23 suppresses the immune response during tumor initiation, growth, and metastases, and neutralization of
Bianca von Scheidt +6 more
semanticscholar +6 more sources
Bullous pemphigoid induced by anti-IL-23 monoclonal antibody in a psoriatic patient: a case report. [PDF]
Front Med (Lausanne)Psoriasis, a chronic immune-mediated inflammatory skin disorder, is increasingly managed with anti-IL-23 biologics, such as guselkumab. Nevertheless, their rare adverse effects remain poorly understood. This study presents the case of a 78-year-old woman with moderate-to-severe psoriasis who presented with bullous pemphigoid (BP) 2 weeks after ...
Xi R +5 more
europepmc +3 more sources
Pharmacokinetics of Tildrakizumab (MK‐3222), an Anti‐IL‐23 Monoclonal Antibody, After Intravenous or Subcutaneous Administration in Healthy Subjects [PDF]
Basic & Clinical Pharmacology & Toxicology, 2018 AbstractTildrakizumab, a high‐affinity humanized IgG1k antibody that selectively binds interleukin (IL)‐23 p19 subunit of cytokine IL‐23 and neutralizes its function, is under investigation for treatment of moderate‐to‐severe chronic plaque psoriasis.
Sauzanne G Khalilieh +5 more
semanticscholar +3 more sources
Anti-IL-23 monoclonal antibody synergizes in combination with targeted therapies or IL-2 to suppress tumor growth and metastases. [PDF]
Cancer Research, 2011 Immunosuppressive barricades erected by tumors during the evolution of immune escape represent a major obstacle to many potentially effective cancer therapies and vaccines. We have shown that host interleukin (IL)-23 suppresses the innate immune response
M. Teng +4 more
semanticscholar +6 more sources
Mediators of Inflammation, 2020 Asthma is a heterogeneous chronic inflammatory disorder of the airways with a complex etiology, which involves a variety of cells and cellular components.
Yingli Zhang +5 more
doaj +2 more sources
JAMA DermatolImportancePsoriasis is a chronic, immune-mediated skin disease with an unmet need for biologic treatment options.ObjectiveTo assess the safety, pharmacokinetics, and efficacy of QX004N in healthy individuals and patients with moderate to severe plaque psoriasis in China.Design, Setting, and ParticipantsThis randomized clinical trial was composed of 2 ...
Li X +13 more
europepmc +4 more sources
Psoriasis and inflammatory bowel disease: concomitant IMID or paradoxical therapeutic effect? A scoping review on anti-IL-12/23 and anti-IL-23 antibodies [PDF]
Therapeutic Advances in GastroenterologyInflammatory bowel diseases (IBD) and psoriasis are chronic inflammatory conditions belonging to the heterogeneous group of immune-mediated inflammatory diseases (IMIDs).
Cristina Bezzio +9 more
doaj +2 more sources
Anti-IL-23-antistoffer mot prostatakreft? [PDF]
Tidsskrift for Den norske legeforening, 2019 H. B. Benestad
semanticscholar +2 more sources
Frontiers in PharmacologyIntroductionPersistent synovial hyperplasia, a hallmark of rheumatoid arthritis (RA), can lead to joint deformities. During the pathogenesis of RA, the expression of IL-23 promotes Th17 cell proliferation and IL-17 production, which in turn upregulates ...
Yuxin Chen +10 more
doaj +2 more sources