Results 31 to 40 of about 874,981 (155)

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati, Aziz Farah Izati, Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Mini Review: New Treatments in Psoriatic Arthritis. Focus on the IL-23/17 Axis

Frontiers in Pharmacology, 2019
Psoriasis, an inflammatory skin disease, and psoriatic arthritis (PsA), an inflammatory arthritis, share clinical, genetic, and pathogenic factors and may be summed as one disease, the psoriatic disease.
Lazaros I. Sakkas, Efterpi Zafiriou, Dimitrios P. Bogdanos   +2 more
doaj   +1 more source

ROLE OF INTERLEUKIN-23 AS A MARKER OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS PATIENTS [PDF]

Zagazig University Medical Journal, 2018
Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. The pathogenesis of RA is mediated by an interdependent network of cytokines which has been extended to include the cytokine, IL-23.
Enas El desoky, Heba Gawish, Abeer El-shafey, Mazen Al Sheikh   +3 more
doaj   +1 more source

IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis. [PDF]

PLoS ONE, 2013
IL-23p19 deficient mice have revealed a critical role of IL-23 in the development of experimental autoimmune diseases, such as collagen-induced arthritis (CIA).
Ferry Cornelissen, Patrick S Asmawidjaja, Adriana M C Mus, Odilia Corneth, Kristine Kikly, Erik Lubberts   +5 more
doaj   +1 more source

Safety of interleukin inhibitors in patients with plaque psoriasis and history of neoplasms: a multicenter retrospective study – IL PSO (Italian landscape psoriasis)

Journal of Dermatological Treatment
Background: Interleukin (IL) inhibitors are increasingly used in the management of moderate-to-severe plaque psoriasis. However, their use in patients with a history of cancer is debated.Objective: We conducted a multicenter retrospective study across ...
Mario Valenti, Luciano Ibba, Sara Di Giulio, Luigi Gargiulo, Piergiorgio Malagoli, Anna Balato, Carlo G. Carrera, Paolo Dapavo, Eugenia V. Di Brizzi, Valentina Dini, Francesca Gaiani, Francesco Loconsole, Angelo V. Marzano, Matteo Megna, Alessandra Michelucci, Luca Potestio, Simone Ribero, Antonio Costanzo, Alessandra Narcisi   +18 more
doaj   +1 more source

A 3-Year Multicentric Study on Switching from Ustekinumab to Guselkumab in Partial Responders with Psoriasis—IL PSO (Italian Landscape Psoriasis)

Dermatology and Therapy
Introduction Guselkumab, a human monoclonal antibody targeting the p19 subunit of interleukin-23 (IL-23), has shown efficacy in psoriasis and psoriatic arthritis.
Mario Valenti, Luciano Ibba, Ruggero Cascio Ingurgio, Piergiorgio Malagoli, Andrea Carugno, Marco Campoli, Carlo G. Carrera, Francesca M. Gaiani, Davide Strippoli, Federica Mola, Angelo V. Marzano, Nicola Zerbinati, Anna Minuti, Antonio Costanzo, Alessandra Narcisi   +14 more
doaj   +1 more source

Anti-IL-17/23 Drugs for the Treatment of Moderate-to-Severe Hidradenitis Suppurativa in Patients With Concomitant Psoriasis: A Multicenter Retrospective Study

Dermatology Practical & Conceptual
Introduction: Psoriasis and hidradenitis suppurativa (HS) are chronic inflammatory diseases with significant overlap in their immunologic pathways, which involve cytokines such as tumor necrosis factor-alfa, interleukin (IL)-17, and IL-23.
Luigi Gargiulo, Luciano Ibba, Alessandra Narcisi, Silvia Giordano, Carlo A. Maronese, Fabrizio Martora, Federica Repetto, Giovanni Paolino, Anna Balato, Martina Burlando, Paolo Dapavo, Valentina Dini, Claudio Guarneri, Angelo V. Marzano, Matteo Megna, Santo R. Mercuri, Antonio Costanzo, Mario Valenti   +17 more
doaj   +1 more source

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

Frontiers in Immunology, 2018
IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence suggests, however, that IL-17A and IL-23 have a partially overlapping but distinct biology. We
Melissa N. van Tok, Melissa N. van Tok, Songqing Na, Christopher R. Lao, Marina Alvi, Desirée Pots, Desirée Pots, Marleen G. H. van de Sande, Marleen G. H. van de Sande, Joel D. Taurog, Jonathon D. Sedgwick, Jonathon D. Sedgwick, Dominique L. Baeten, Dominique L. Baeten, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde   +15 more
doaj   +1 more source

Efficacy and drug survival after transitioning to IL-17 inhibitors in patients with psoriasis who did not respond to IL-23 inhibitors: analysis from the BIOREP registry

Journal of Dermatological Treatment
Introduction Switching biologics for psoriasis is common; however, data on switching to alternative treatments after failure of IL-23 inhibitors are limited.Methods A retrospective analysis was conducted to extract efficacy and drug survival data from ...
Filip Rob, Alena Machovcová, Marie Jandová, Martin Tichý, Yveta Vantuchová, Miroslav Nečas, Martina Kojanová, Petra Cetkovská, Jana Třešňák Hercogová, Spyridon Gkalpakiotis   +9 more
doaj   +1 more source

Erythrodermic psoriasis improved by tildrakzumab: a case report

Dermatology Reports, 2022
Erythrodermic psoriasis (EP), clinically defined as prominent erythema and scaling affecting almost the entire skin surface, is a severe form and a rare variant of psoriasis.
Giampaolo Trevisan, Lerica Germi, Luigi Naldi   +2 more
doaj   +1 more source