Results 111 to 120 of about 4,687,299 (337)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A genome-wide association study for somatic cell score using the Illumina high-density bovine beadchip identifies several novel QTL potentially related to mastitis susceptibility [PDF]

, 2013
peer-reviewedMastitis is an inflammation-driven disease of the bovine mammary gland that occurs in response to physical damage or infection and is one of the most costly production-related diseases in the dairy industry worldwide.
Alan eFahey, Brian eMeredith, Brian eMeredith, Dan eBradley, David eLynn, Donagh eBerry, Emma eFinlay, Francis eKearney   +7 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradation

Acta Pharmaceutica Sinica B
Poly(ADP-ribosyl)ation (PARylation) is a specific form of post-translational modification (PTM) predominantly triggered by the activation of poly-ADP-ribose polymerase 1 (PARP1).
Xiangyu Li, Xiaoyu Shen, Xinfei Mao, Yuqing Wang, Yuhang Dong, Shuai Sun, Mengmeng Zhang, Jie Wei, Jianan Wang, Chao Li, Minglu Ji, Xiaowei Hu, Xinyu Chen, Juan Jin, Jiagen Wen, Yujie Liu, Mingfei Wu, Jutao Yu, Xiaoming Meng   +18 more
doaj   +1 more source

Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide. [PDF]

, 2015
BackgroundTemozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue.
Bui, Yvonne, Cloughesy, Timothy F, Hong, Irene, Lai, Albert, Liau, Linda M, McBride, William H, Menjivar, Jimmy C, Nelson, Stanley F, Stream, Alexandra, Tso, Cho-Lea, Tso, Jonathan L, Yamada, Kazunari, Yang, Shuai, Yong, William H, Zhang, Yibei   +14 more
core   +2 more sources

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

Chemical Science, 2018
Reactive oxygen species (ROS) scavenging Mn3O4 nanozymes effectively protected live mice from ROS-induced ear-inflammation in vivo.
Jia Yao, Yuan Cheng, Min Zhou, Sheng Zhao, Shichao Lin, Xiaoyu Wang, Jiangjiexing Wu, Sirong Li, Hui Wei   +8 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Electrospinning of poly(ethylene-co-vinyl alcohol) nanofibres encapsulated with Ag nanoparticles for skin wound healing [PDF]

, 2011
Copyright © 2011 Chao Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Skin ...
Lu, T, Wang, B, Xu, C, Xu, F
core   +2 more sources

Anti-Inflammation Assay of Black Soybean Extract and Its Compounds on Lipopolysaccharide-Induced RAW 264.7 Cell

Journal of Physics: Conference Series, 2019
Inflammation response is related with various diseases. One of the useful therapeutic method to suppress inflammatory mediator synthesis is by application of compounds isolated from herbal medicine as treatment for inflammatory diseases.
Wahyu Widowati, S. Prahastuti, N. Ekayanti, U. Z. Munshy, H. Kusuma, S. Wibowo, A. Amalia, W. Widodo, R. Rizal   +8 more
semanticscholar   +1 more source

Characterization and anti-inflammation role of swine IFITM3 gene

Oncotarget, 2017
IFITM3 is involved in cell adhesion, apoptosis, immune, and antivirus activity. Furthermore, IFITM3 gene has been considered as a preferential marker for inflammatory diseases, and positive correlation to pathological grades. Therefore, we assumed that IFITM3 was regulated by different signal pathways.
Li, H.-P, Chen, P.-G, Liu, F.-T, Zhu, H.-S, Jiao, X.-Q, Zhong, K, Guo, Y.-J, Zha, G.-M, Han, L.-Q, Lu, W.-F, Wang, Y.-Y, Yang, G.Y   +11 more
openaire   +3 more sources