Results 131 to 140 of about 1,234,464 (310)

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters
AbstractInflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects.
Amal George Kurian, Rajendra K. Singh, Varsha Sagar, Jung-Hwan Lee, Hae-Won Kim   +4 more
openaire   +3 more sources

Co-delivery of camptothecin and MiR-145 by lipid nanoparticles for MRI-visible targeted therapy of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research
Background Camptothecin (CPT) is one of the frequently used small chemotherapy drugs for treating hepatocellular carcinoma (HCC), but its clinical application is limited due to severe toxicities and acquired resistance.
Jing Rong, Tongtong Liu, Xiujuan Yin, Min Shao, Kun Zhu, Bin Li, Shiqi Wang, Yujie Zhu, Saisai Zhang, Likang Yin, Qi Liu, Xiao Wang, Lei Zhang   +12 more
doaj   +1 more source

Fasudil in Combination With Bone Marrow Stromal Cells (BMSCs) Attenuates Alzheimer\u27s Disease-Related Changes Through the Regulation of the Peripheral Immune System. [PDF]

, 2018
Alzheimer\u27s disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation.
Chai, Zhi, Chumber, Jasleen, Gao, Ye, Gu, Qingfang, Jiang, Yuqiang, Kumar, Gajendra, Liu, Chunyun, Ma, Cun-Gen, Xiao, Bao-Guo, Yan, Yuqing, Yu, Hongqiang, Yu, Jiezhong, Zhang, Guang-Xian, Zhang, Han-Ting, Zhao, Yijin   +14 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Experimental Study on Anti-inflammation and Anti-oxidation of Sopungdojeok-tang(Xiaofengdaochi-tang) and Samulsopungsan(Siwuxiaofeng-san)

Journal of Pharmacopuncture, 2010
Objective: This experimental study was performed to investigate the anti-inflammation and anti-oxidant effects of Sopungdojeok-tang(SPDJT) and Samulsopung-san(SMSPS) which were used to treat patient with atopic dermatitis Methods: Anti-inflammation and ...
Hyung-Sik Seo
doaj   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Anti-DAMP therapies for acute inflammation

Frontiers in Immunology
Shock, affecting a third of intensive care patients, remains a highly fatal condition despite advances in critical care, irrespective of its etiology. Cellular injury, central to shock pathophysiology, triggers the release of damage-associated molecular ...
Russell Hollis, Russell Hollis, Russell Hollis, Megan Tenet, Megan Tenet, Monowar Aziz, Monowar Aziz, Monowar Aziz, Ping Wang, Ping Wang, Ping Wang   +10 more
doaj   +1 more source