Results 111 to 120 of about 1,249,360 (312)

Anti inflammatory property of salbutamol on acute and chronic models of inflammation

National Journal of Physiology, Pharmacy and Pharmacology, 2015
Background: β2-Adrenergic receptor agonist agents were able to suppress the immune response by inhibiting release of IL-12 and production of TNF-α by the direct stimulation of β-adrenergic receptors on inflammatory immune ...
Asha D Jadhav, Sudhir L Padwal, Rakesh R Jadhav, Swapnil S Jadhav, Harshal N Pise, Mangal K Choure   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

In vitro evaluation of the antibacterial and anti-inflammation activities of Clausena lansium (Lour.) Skeels [PDF]

, 2015
Crude extracts of twigs and roots of Clausena lansium (Lour.) Skeels were separated and purified using repeated silica gel column chromatography to yield 12 compounds identified as xanthotoxol (1), imperatorin (2), heraclenol (3), heraclenin (4 ...
Pirasut Rodanant, Rudee Surarit, Surat Laphookhieo, Jintakorn Kuvatanasuchati   +3 more
core  

Research progress of anti-inflammation therapy and immunotherapy for acute pancreatitis [PDF]

At present, the incidence and mortality rate of severe acute pancreatitis is 15%-20% and about 20%, respectively, which can lead to local and systemic complications of patients and huge medical costs.
Feng ZHU, Yanping GU
core   +1 more source

PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradation

Acta Pharmaceutica Sinica B
Poly(ADP-ribosyl)ation (PARylation) is a specific form of post-translational modification (PTM) predominantly triggered by the activation of poly-ADP-ribose polymerase 1 (PARP1).
Xiangyu Li, Xiaoyu Shen, Xinfei Mao, Yuqing Wang, Yuhang Dong, Shuai Sun, Mengmeng Zhang, Jie Wei, Jianan Wang, Chao Li, Minglu Ji, Xiaowei Hu, Xinyu Chen, Juan Jin, Jiagen Wen, Yujie Liu, Mingfei Wu, Jutao Yu, Xiaoming Meng   +18 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Development of a New Salt of Piperine with Toluene Sulfonic Acid and Its Anti-Inflammation Effect In Vivo [PDF]

Piperine (PPN) is a natural compound with an anti-inflammation effect and low solubility. Hence, some molecular modifications have improved its solid-state character, including cocrystal formation. However, the salt structure has yet to be widely studied.
Kusnandar Anggadiredja, Hidehiro Uekusa, Yuto Abekura, Ilma Nugrahani, Ari Sartinah, Slamet Ibrahim   +5 more
core   +1 more source

Influence of Boiling, Steaming and Frying of Selected Leafy Vegetables on the In Vitro Anti-inflammation Associated Biological Activities [PDF]

, 2018
The aim of the present study was to evaluate the effect of cooking (boiling, steaming, and frying) on anti-inflammation associated properties in vitro of six popularly consumed green leafy vegetables in Sri Lanka, namely: Centella asiatica, Cassia ...
K. Gunathilake, K. D. P. P. Gunathilake, H. P. V. Rupasinghe, K. Ranaweera, K. K. D. S. Ranaweera, H. Rupasinghe   +5 more
core   +1 more source