Results 121 to 130 of about 1,249,360 (312)

The Anti-Inflammation and Anti-Nociception Effect of Ketoprofen in Rats Could Be Strengthened Through Co-Delivery of a H2S Donor, S-Propargyl-Cysteine

Journal of Inflammation Research, 2021
Yue Yu,1,* Qinyan Yang,1,* Zhou Wang,1 Qian Ding,1 Meng Li,1 Yudong Fang,1 Qida He,1 Yi Zhun Zhu1,2 1State Key Laboratory of Quality Research in Chinese Medicine & School of Pharmacy, Macau University of Science and Technology, Taipa, Macau SAR ...
Yu Y, Yang Q, Wang Z, Ding Q, Li M, Fang Y, He Q, Zhu YZ   +7 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The underlying mechanism for anti-acne activity of hemp seed hexane extracts via anti-inflammation in P.acnes-stimulated HaCaT cells and anti-lipogenesis in sebocytes. [PDF]

, 2018
The underlying mechanism for anti-acne activity of hemp seed hexane extracts via anti-inflammation in P.acnes-stimulated HaCaT cells and anti-lipogenesis in sebocytes.
Mi-Young Lee (3694627), Solee Jin, Solee Jin (3694618), Mi-Young Lee   +3 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Supplemental_Data_pdf – Supplemental material for Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation [PDF]

, 2019
Supplemental material, Supplemental_Data_pdf for Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation by Hao Liu, Ranli Gu, Wei Li, Wen Zhou, Zhe Cong, Jing Xue,
Wei Li (7081), Yunsong Liu (284270), Jing Xue (170229), Qiang Wei (187077), Yongsheng Zhou (284273), Zhe Cong (452962), Ranli Gu (6914789), Wen Zhou (49050), Hao Liu (12832)   +8 more
core   +1 more source

Decoding m6A mRNA methylation by reader proteins in liver diseases

Genes and Diseases
N6-methyladenosine (m6A) is a dynamic and reversible epigenetic regulation. As the most prevalent internal post-transcriptional modification in eukaryotic RNA, it participates in the regulation of gene expression through various mechanisms, such as mRNA ...
Lijiao Sun, Xin Chen, Sai Zhu, Jianan Wang, Shaoxi Diao, Jinyu Liu, Jinjin Xu, Xiaofeng Li, Yingyin Sun, Cheng Huang, Xiaoming Meng, Xiongwen Lv, Jun Li   +12 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Bee Venom Acupuncture Augments Anti-Inflammation in the Peripheral Organs of hSOD1G93A Transgenic Mice [PDF]

, 2015
Amyotrophic lateral sclerosis (ALS) includes progressively degenerated motor neurons in the brainstem, motor cortex, and spinal cord. Recent reports demonstrate the dysfunction of multiple organs, including the lungs, spleen, and liver, in ALS animals ...
Sun-Mi Choi, Sun-Hwa Lee, Eun Jin Yang, Eun Yang   +3 more
core   +1 more source

Genetic Engineering Bacillus thuringiensis Enable Melanin Biosynthesis for Anti‐Tumor and Anti‐Inflammation

Advanced Science
Collaboration between cancer treatment and inflammation management has emerged as an integral facet of comprehensive cancer care. Nevertheless, the development of interventions concurrently targeting both inflammation and cancer has encountered ...
Meng Chen, Bingbing Guo, Hui Cheng, Weiyi Wang, Junyi Jin, Yingyi Zhang, Xiaolian Deng, Wenjun Yang, Chenyao Wu, Xiang Gao, Dehong Yu, Wei Feng, Yu Chen   +12 more
doaj   +1 more source