Results 141 to 150 of about 1,234,464 (310)
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Anti-inflammation strategy: potential brain protection in cerebral ischemia
Folia Pharmacologica Japonica, 2009 脳梗塞急性期の治療薬として現在国際的に使用されているのは血栓溶解薬のみである．しかしその恩恵を受けることのできる患者は脳梗塞全体の5%以下であり，脳梗塞に有効な保護薬の開発が期待される．これまでグルタミン酸受容体拮抗薬をはじめとした神経細胞を主な標的とした治療薬は基礎実験では有効なものの臨床試験では有用性が証明されなかった．神経細胞だけでなく脳梗塞進展に密接に関連しているミクログリアや脳血管内皮細胞でも虚血侵襲により炎症反応が誘導される．さらに血栓溶解療法に伴って発生する血液脳関門障害，出血性脳梗塞の発生にも血管周囲での炎症反応が関与していると想定される．炎症制御を標的とした治療薬の開発は有望と考えられるが，脳梗塞治療手段として取り入れる場合には，炎症反応は組織障害性に働くだけでなく，虚血耐性の獲得，
openaire +3 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy
Frontiers in ImmunologyAcute inflammation is elicited by lipid and protein mediators in defense of the host following sterile or pathogen-driven injury. A common refrain is that chronic inflammation is a result of incomplete resolution of acute inflammation and behind the ...
Krishna Rao Maddipati
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Editorial: Epigenetic Regulation in Renal Development, Physiology and Disease
Frontiers in Physiology, 2022 Juan Jin +3 more
doaj +1 more source
Investigation the effect of Papaver Rhoeas, Malva Grandfolia, and Carduus Marianus Leaves Extracts on Mild Steel in HCl solution, by using weight loss method and linear polarisation resistance technique [PDF]
, 2012 We can say mild steel studied corrodes in hydrochloric acid solutions, and also mild steel corrodes when exposed to a solution of HCl and the rate of corrosion increases as the immersion time increases.
Kandemirli, Vedat Burak
core
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source