Results 91 to 100 of about 1,249,360 (312)

Anti-Inflammation Property of Syzygium cumini (L.) Skeels on Indomethacin-Induced Acute Gastric Ulceration [PDF]

, 2015
Indomethacin, nonsteroidal anti-inflammatory drug (NSAIDs), induced gastric damage and perforation through the excess generation of reactive oxygen species (ROS).
Lanchakon Chanudom, Jitbanjong Tangpong
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Versatile Carbon Monoxide Nanogenerator for Enhanced Tumor Therapy and Anti-Inflammation [PDF]

, 2019
Carbon monoxide (CO) is regarded as a potential therapeutic agent with multiple beneficial functions for biomedical applications. In this study, a versatile CO nanogenerator (designated as PPOSD) was fabricated and developed for tumor therapy and anti ...
Lei Rong (1488667), Lei Rong, Shi-Bo Wang (397485), Chuan-Jun Liu (1628380), Jing-Jie Ye, Shi-Bo Wang, Zhao-Xia Chen, Zhao-Xia Chen (6668321), Si-Yuan Peng (6668327), Xian-Zheng Zhang (1449169), Cheng Zhang (70708), Si-Yuan Peng, Cheng Zhang, Chuan-Jun Liu, Jing-Jie Ye (6668324), Xian-Zheng Zhang   +15 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Promote Recovery after Rat Spinal Cord Injury by Altering Macrophage Polarity [PDF]

, 2015
Engrafted mesenchymal stem cells from human deciduous dental pulp (SHEDs) support recovery from neural insults via paracrine mechanisms that are poorly understood.
Kondo, Megumi, Matsubara, Kohki, Matsushita, Yoshihiro, Imagama, Shiro, Suzumura, Akio, Furukawa, Koichi, Hashimoto, Noboru, Ishiguro, Naoki, Ueda, Minoru, Yamamoto, Akihito, Noda, Mariko, Sakai, Kiyoshi, Kano, Fumiya   +12 more
core   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science
RNA 5‐methylcytosine (m5C) modification plays a critical role in multiple diseases; however, its function in hyperuricaemic nephropathy (HN) remains unclear.
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
doaj   +1 more source

Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context

EBioMedicine
Summary: Background: Acute kidney injury (AKI) is a critical clinical syndrome with high morbidity, mortality, and no effective treatment in clinical practice.
Ming-lu Ji, Jia-nan Wang, Ming-fei Wu, Chuan-hui Xu, Meng-meng Zhang, Wen-bao Chang, Xin-fei Mao, Chao Li, Ju-tao Yu, Dan-feng Zhang, Xiao-guo Suo, Shao-xi Diao, Nan-nan Ma, Ying Chen, Rui Hou, Hao Lu, Shuai-shuai Xie, Yu-hang Dong, Qi Zhu, Xin Chen, Tao Xu, Wei Shao, Juan Jin, Jia-gen Wen, Xiao-wu Dong, Wen-bin Wang, Jin-xin Che, Xiao-ming Meng   +27 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Oftimizing Combination of Sambiloto Herbal Water Fraction and Salam Leaf Water Fration As Anti-Inflammation [PDF]

, 2015
Sambiloto herbs (Andrographis panicu/ata Nees) and salam leaves (Syzygium polyanthum), which are effective to reduce blood sugar level with different mechanism, have been suggested to produce a synergy as antioxidant and anti-inflammatory agent, hence ...
Mustafa, Raymond Harris, Tamayanti, Wahyu Dewi, Hadisoewignyo, Lannie, Soegianto, Lisa, Ervina, Martha   +4 more
core  

A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions

Current Research in Food Science
Microplastics (MPs) are widely distributed and accumulated in the environment, making it nearly impossible for humans to avoid ingestion. Their toxicity can cause serious health damage and pose a threat to human health.
Li Zheng-Qiang, Li Jun, An Rui, Li Rui, Deng Wei, Ma Ping, Yang Xu, She Rong, Yang Xiao-Yan, Xiao Wen   +9 more
doaj   +1 more source