Results 81 to 90 of about 1,249,360 (312)

Studies on the antibacterial activity, antioxidation,anti-inflammation and anticancer activity of Wedelia trilobata (L.) itchc. [PDF]

, 2009
[[abstract]]Wedelia trilobata (L.) Hitchc. is used in folk medicine. It is reported that the plant shows antibacterial activity and contents antitumor chemical components.
Lai Chung Wei
core  

Characterization of the anti-inflammation mechanism for the AO herbal extract

Experimental and Molecular Pathology, 2016
A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated.
Ye, Hong, Wang, Yali, Yan, Jun, Jenson, A. Bennett   +3 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Lactylation: the metabolic–immune hub in autoimmune diseases

Frontiers in Immunology
In recent years, lactate modification, as an emerging post-translational modification mechanism, has attracted increasing attention for its role in the regulation of the immune system. Autoimmune diseases are a category of complex disorders characterized
Qingqing Xia, Qingqing Xia, Dantong Sun, Dantong Sun, Ke Wan, Chengcheng Liu, Han Shu, Miao Wang, Tongsheng Zhou, Tongsheng Zhou, Ying Chen, Xue Yang, Xiao-Feng Li, Xiao-Feng Li, Biao Song, Biao Song, Facai Wang, Facai Wang   +17 more
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Frontiers in Pharmacology, 2018
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects
Heng Li, Heng Li, Jianping Zuo, Jianping Zuo, Wei Tang, Wei Tang, Wei Tang   +6 more
doaj   +1 more source

Antinociceptive Activities and the Mechanisms of Anti‐Inflammation of Asiatic Acid in Mice [PDF]

Evidence-Based Complementary and Alternative Medicine, 2011
Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plantCentella asiatica, was evaluated for antinociceptive and anti‐inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid‐induced writhing responses and the formalin‐induced pain in the late phase. In the anti‐inflammatory test, AA
Huang, Shyh-Shyun, Chiu, Chuan-Sung, Chen, Hsien-Jung, Hou, Wen-Chi, Sheu, Ming-Jyh, Lin, Ying-Chih, Shie, Pei-Hsin, Huang, Guan-Jhong   +7 more
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease

Nature Communications
Renal tubulointerstitial abnormalities predict diabetic kidney disease (DKD) progression, and targeting them may prevent DKD. Insulin-like growth factor binding-protein 7 (IGFBP7) is expressed in renal tubular cells and is elevated in both blood and ...
Ju-tao Yu, Xiao-wei Hu, Jia-nan Wang, Qin Yang, Xiang-yu Li, Run-run Shan, Tian Pu, Rui Hou, Xiao-yu Shen, Yu-qin Wang, Fei Zhang, Xiao-wen Yu, Jie Wang, Feng-he Li, Jia-gen Wen, Ying Fan, Juan Jin, Yi-yang Jiang, Xiao-ming Meng   +18 more
doaj   +1 more source

In case of obesity, longevity-related mechanisms lead to anti-inflammation [PDF]

AGE, 2013
The exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model.
Kaya, Mehmet Salih, Bayiroglu, Fahri, Mis, Leyla, Kilinc, Dide, Comba, Bahat, Belirlenecek, [Kaya, Mehmet Salih] Dicle Univ, Dept Physiol, TR-21280 Diyarbakir, Turkey -- [Bayiroglu, Fahri -- Mis, Leyla -- Kilinc, Dide -- Comba, Bahat] Yuzuncu Yil Univ, Dept Physiol, TR-65080 Campus, Van, Turkey -- [Bayiroglu, Fahri] Ibrahim Cecen Univ Agri, Agri, Turkey   +6 more
openaire   +8 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source