Results 81 to 90 of about 3,781,173 (304)

Characterization of the anti-inflammation mechanism for the AO herbal extract

Experimental and Molecular Pathology, 2016
A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminated.
Ye, Hong, Wang, Yali, Yan, Jun, Jenson, A. Bennett   +3 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation [PDF]

, 2002
Macrophage clearance is essential for the resolution of inflammation. Much is known about how monocytes enter the inflammatory site but little is known about how resultant macrophages are cleared. We have previously demonstrated that macrophage clearance
Mutsaers, SE, Bottoms, S, Cooksley, H, Helen Cauldwell, Bellingan, GJ, Christopher Haslett, Xu, P, Haslett, C, Geoffrey John Laurent, Steven Eugene Mutsaers, Anthony Shock, Laurent, GJ, Ping Xu, Stephen Bottoms, Cauldwell, H, Shock, A, Helen Cooksley, Geoffrey John Bellingan   +17 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Carbon Quantum Dots Derived from Herbal Medicine as Therapeutic Nanoagents for Rheumatoid Arthritis with Ultrahigh Lubrication and Anti-inflammation

, 2023
As a typical chronic inflammatory joint disease with swelling and pain syndromes, rheumatoid arthritis (RA) is closely related to articular lubrication deficiency and excessive proinflammatory cytokines in its progression and pathogenesis.
Haofei Huang (1990042), Jia Chen, Guowang Xu (135666), Hongdeng Qiu, Haofei Huang, Xianzhe Shi (1876138), Guowang Xu, Ruibin Qiang, Ruibin Qiang (10702742), Zengjie Fan, Zengjie Fan (1955581), Hongdeng Qiu (1572232), Xianzhe Shi, Jia Chen (8203)   +13 more
core   +1 more source

PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradation

Acta Pharmaceutica Sinica B
Poly(ADP-ribosyl)ation (PARylation) is a specific form of post-translational modification (PTM) predominantly triggered by the activation of poly-ADP-ribose polymerase 1 (PARP1).
Xiangyu Li, Xiaoyu Shen, Xinfei Mao, Yuqing Wang, Yuhang Dong, Shuai Sun, Mengmeng Zhang, Jie Wei, Jianan Wang, Chao Li, Minglu Ji, Xiaowei Hu, Xinyu Chen, Juan Jin, Jiagen Wen, Yujie Liu, Mingfei Wu, Jutao Yu, Xiaoming Meng   +18 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparação do efeito de farmacos antiartríticos e anticorpos anti-citocinas na artrite reativa ao LPS em ratos [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O objetivo geral deste estudo foi avaliar o efeito de anticorpos anti-citocinas pró e antiinflamatórias na ...
Bressan, Elisângela
core  

Low grade chronic inflammation and anti-inflammatory diet: effect on Rheumatoid arthritis [PDF]

, 2023
openThis work focus on what low grade inflammation is and how this human health condition can be detected and which effect has on human health. How nutrition can be usefull to control or improve inflammation through a specific diet and how the diet must ...
BAZZAN, NICOLÒ
core