Results 81 to 90 of about 1,234,464 (310)

Pulmonary outcomes following specialized respiratory management for acute cervical spinal cord injury: a retrospective analysis. [PDF]

open access: yes, 2017
Study designRetrospective analysis.ObjectivesTo identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increase successful liberation from ...
Crew, JD   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Effect of Oscimum Sanctum to the Thrombocytes Number on Mice [PDF]

open access: yes, 2016
Oscimum sanctum is herbal that was spread widely in Indonesia. Oscimum sanctum contains abundant of substances. One of the functions on Oscimum sanctum was anti-thrombocytes effect. This effect is associated with platelet function as a mechanical plug in
Astuti, Y. (Yoni), Wijayanti, R. (Rum)
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Antioxidant Capacity Of Frangipani (Plumeria Alba) Powder Extract [PDF]

open access: yes, 2011
This research aimed to identify the antioxidant capacity, vitamin C (ascorbic acid), and total phenolic compounds of frangipani flower powder. The powder was extracted using ethanol, methanol, acetic acid, and water (aquadest).
Bagiada, N. A. (Nyoman)   +3 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context

open access: yesEBioMedicine
Summary: Background: Acute kidney injury (AKI) is a critical clinical syndrome with high morbidity, mortality, and no effective treatment in clinical practice.
Ming-lu Ji   +27 more
doaj   +1 more source

Anti-hipercholesterolemia of Anredera Cordifolia in Hypercholesterolemia Rat Wistar Through Decrease of Malondialdehyde and 8-hydroxy-diguanosine [PDF]

open access: yes, 2014
High cholesterol diet leads to increase of plasma cholesterol and subsequently will end up with hypercholesterolemia. Ignorance of healthy food and lacks of activity are the trend of modern life style.
Wahjuni, S. (S)
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions

open access: yesCurrent Research in Food Science
Microplastics (MPs) are widely distributed and accumulated in the environment, making it nearly impossible for humans to avoid ingestion. Their toxicity can cause serious health damage and pose a threat to human health.
Li Zheng-Qiang   +9 more
doaj   +1 more source

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