Results 61 to 70 of about 1,249,360 (312)

Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti‐inflammation, anti‐apoptosis, and ERK activation

FEBS Open Bio, 2021
ATP‐sensitive potassium channels (KATPs) have protective effects in ischemia–reperfusion‐induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis, and survival in ...
Lei Tian, Shiwei Wang, Li Zhao, Xiaoye Lu, Changqing Zhu, Hao Gong, Weiqiang Yang   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Polyoxometalate-Encapsulated Metal–Organic Framework Nanoplatform for Synergistic Photothermal–Chemotherapy and Anti-Inflammation of Ovarian Cancer [PDF]

, 2022
Photothermal therapy (PTT), as a noninvasive and local treatment, has emerged as a promising anti-tumor strategy with minimal damage to normal tissue under spatiotemporally controllable irradiation.
Guiqi Ma, Yuqi Wang, Wang, Yuqi, Liu, Shuangqing, Jipeng Wan, Diqing Wang, Qian Lv, Changzhong Li, Xiao Sun, Xinyu Zhang, Chenyu Wang, Gao, Yuan, Zhang, Xinyu, Wang, Diqing, Li, Changzhong, Lv, Qian, Shuangqing Liu, Wang, Chenyu, Sun, Xiao, Wan, Jipeng, Ma, Guiqi, Yuan Gao   +21 more
core   +1 more source

Biosynthetic ε-poly-L-lysine for the treatment of extensively- and pan-drug-resistant Pseudomonas aeruginosa

npj Antimicrobials and Resistance
Pseudomonas aeruginosa (PA) represents a major cause of antimicrobial resistance-related morbidity and mortality. The recent emergence of highly fatal infections, caused by carbapenem-resistant PA, has called for novel antimicrobial therapies and ...
Darren Shu Jeng Ting, Thet Tun Aung, Venkatesh Mayandi, Mercy Halleluyah Periayah, Eunice Tze Leng Goh, Mugil Muthu, Veluchamy Amutha Barathi, Jodhbir S. Mehta, Donald Tiang Hwee Tan, Rajamani Lakshminarayanan   +9 more
doaj   +1 more source

Systemic sclerosis-associated pulmonary arterial hypertension and pulmonary fibrosis: exploring biomarker discriminators with advanced omics in a Caucasian cohort

Frontiers in Immunology
IntroductionSystemic sclerosis (Scleroderma; SSc) is associated with high morbidity and mortality, particularly in patients with pulmonary arterial hypertension (SSc-PAH) and pulmonary fibrosis (SSc-PF). Effective risk stratification and treatment of SSc
Nada Mohamed-Ali, Vanessa Acquaah, Maneera Al-Jaber, Rikesh Bhatt, Ibrahim Al-Mohannadi, Konduru Seetharama Sastry, Alka Beotra, Daniel Knight, Daniel Knight, Christopher Denton, Voon Ong, Maryam Ali Al-Nesf, Maryam Ali Al-Nesf, David Abraham, Mohammed Al-Maadheed, Mohammed Al-Maadheed, Markella Ponticos, Vidya Mohamed-Ali, Vidya Mohamed-Ali   +18 more
doaj   +1 more source

Rape bee pollen alleviates renal tissue damage in diabetic rats via anti‐inflammation, anti‐oxidation, and modulating gut microbiota

eFood, 2023
Rape (Brassica napus L.) bee pollen (RBP) is a functional food rich in nutrients obtained by worker bees collecting rape pollen and mixing it with nectar and bee salivary enzymes.
Yingjun Hu, Simin Chen, Wenrui Yan, Le Ji, Mengli Shao, Ze Sun, Dong He, Lijun Zhang, Zengrun Xia, Xinsheng Li, Hongxing Zheng, Shanshan Qi   +11 more
doaj   +1 more source

Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Frontiers in Pharmacology, 2022
Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis.
Bingbing Hou, Bingbing Hou, Bingbing Hou, Mingming Liu, Yang Chen, Yang Chen, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Yuexian Xu, Yuexian Xu, Qiushi He, Qiushi He, Qiushi He, Xiaoming Meng, Zongyao Hao, Zongyao Hao, Zongyao Hao   +18 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

DataSheet1_SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.pdf [PDF]

, 2021
Nephrogenic proteins are re-expressed after ischemia/reperfusion (I/R) injury; however, the role of these proteins is still unknown. We found that sine oculis homeobox 1 (SIX1), a developmentally regulated homeoprotein, is reactivated in tubular ...
Yong Jin (566463), Xin Wan (394682), Hong Zhang (25820), Cheng Qian (132529), Manling Zhang (566460), Lihua Zhao (566464), Meishuang Li (8710791), Rongfeng Li (566469), Min Gao (87060), Changchun Cao (417525), Binbin Pan (9379174), Shensen Li (11336472), Hao Zhang (15339)   +12 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source