Results 51 to 60 of about 3,781,173 (304)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Estudo do efeito anti-inflamatório da Croton antisyphiliticus Mart. (Euphorbiaceae) no modelo de pleurisia induzida por carragenina, em camundongos [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2013Introdução: A Croton antisyphiliticus Mart., conhecida popularmente como canela-de-perdiz ou ...
Reis, Gustavo Oliveira dos
core
Investigation into the role of annexin 1 in the microcirculation of annexin 1 knockout mice [PDF]
, 2005 PhDGlucocorticoids are used therapeutically for their anti-inflammatory and immunosuppressive actions. One of the ways they produce their potent effects is via regulation of the anti-inflammatory protein Annexin I (ANX-AI; 37 kDa protein).
Chatterjee, Bristi Emma
core +4 more sources
Mitochondrial dysfunction in ARDS: unraveling the regulatory networks and therapeutic opportunities
Frontiers in ImmunologyAcute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality and limited effective pharmacotherapies. Accumulating evidence has established mitochondrial dysfunction as a central pathogenic hub in ARDS.
Yu-Huan Li +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Avaliação do efeito anti-inflamatório e antibacteriano da Lotus corniculatus v. São Gabriel [PDF]
, 2009 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.A Lotus corniculatus (Fabaceae) é distribuída em muitas regiões do mundo e possui grande valor agronômico por seus ...
Koelzer, Janaína
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Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]
, 2012 Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose Markus A +17 more
core +1 more source
BMC Pharmacology and Toxicology, 2021 Background Taurochenodeoxycholic acid (TCDCA) is one of the major active components in bile acid. It was proven to have inhibitory activities on inflammation and also participate in host immuno-regulation.
Lige Bao +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Nature CommunicationsRenal tubulointerstitial abnormalities predict diabetic kidney disease (DKD) progression, and targeting them may prevent DKD. Insulin-like growth factor binding-protein 7 (IGFBP7) is expressed in renal tubular cells and is elevated in both blood and ...
Ju-tao Yu +18 more
doaj +1 more source