Results 31 to 40 of about 3,781,173 (304)

Biosynthetic ε-poly-L-lysine for the treatment of extensively- and pan-drug-resistant Pseudomonas aeruginosa

npj Antimicrobials and Resistance
Pseudomonas aeruginosa (PA) represents a major cause of antimicrobial resistance-related morbidity and mortality. The recent emergence of highly fatal infections, caused by carbapenem-resistant PA, has called for novel antimicrobial therapies and ...
Darren Shu Jeng Ting, Thet Tun Aung, Venkatesh Mayandi, Mercy Halleluyah Periayah, Eunice Tze Leng Goh, Mugil Muthu, Veluchamy Amutha Barathi, Jodhbir S. Mehta, Donald Tiang Hwee Tan, Rajamani Lakshminarayanan   +9 more
doaj   +1 more source

Systemic sclerosis-associated pulmonary arterial hypertension and pulmonary fibrosis: exploring biomarker discriminators with advanced omics in a Caucasian cohort

Frontiers in Immunology
IntroductionSystemic sclerosis (Scleroderma; SSc) is associated with high morbidity and mortality, particularly in patients with pulmonary arterial hypertension (SSc-PAH) and pulmonary fibrosis (SSc-PF). Effective risk stratification and treatment of SSc
Nada Mohamed-Ali, Vanessa Acquaah, Maneera Al-Jaber, Rikesh Bhatt, Ibrahim Al-Mohannadi, Konduru Seetharama Sastry, Alka Beotra, Daniel Knight, Daniel Knight, Christopher Denton, Voon Ong, Maryam Ali Al-Nesf, Maryam Ali Al-Nesf, David Abraham, Mohammed Al-Maadheed, Mohammed Al-Maadheed, Markella Ponticos, Vidya Mohamed-Ali, Vidya Mohamed-Ali   +18 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Frontiers in Pharmacology, 2022
Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis.
Bingbing Hou, Bingbing Hou, Bingbing Hou, Mingming Liu, Yang Chen, Yang Chen, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Yuexian Xu, Yuexian Xu, Qiushi He, Qiushi He, Qiushi He, Xiaoming Meng, Zongyao Hao, Zongyao Hao, Zongyao Hao   +18 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Atividade anti-hiperalgésica das resolvinas no modelo de dor inflamatória articular em ratos [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011A descoberta de que a resolução da inflamação é um processo ativo, no qual vários mediadores lipídicos
Garcia, Juliana Fabris Lima
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti‐inflammation, anti‐apoptosis, and ERK activation

FEBS Open Bio, 2021
ATP‐sensitive potassium channels (KATPs) have protective effects in ischemia–reperfusion‐induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis, and survival in ...
Lei Tian, Shiwei Wang, Li Zhao, Xiaoye Lu, Changqing Zhu, Hao Gong, Weiqiang Yang   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats

, 2011
Brain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. To test the neuroprotective efficacy of Cordyceps sinensis mycelium (CSM) in a rat model of focal cerebral IR, ischemic animals were treated with CSM.
Liu, Zhenquan, Tang, Huiling, Li, Pengtao, Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China., Zhao, Dan, Guo, Jianyou   +5 more
core   +1 more source