Results 21 to 30 of about 1,234,464 (310)

Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

open access: yesJournal of Advanced Research, 2021
Introduction: Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects.
Heng Li   +11 more
doaj   +1 more source

20-hydroxyecdysone dilates muscle arterioles in a nitric oxide-dependent, estrogen ER-β receptor-independent manner

open access: yesPhytomedicine Plus, 2021
Background: 20-hydroxyecdysone is an ecdysteroid which is abundant in plants and insects and has anabolic potentials in mammals. It was recently shown to have affinity for estrogen ER-β receptor, which could potentially make it vasodilatory.
Nelson N Orie   +9 more
doaj   +1 more source

The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis

open access: yesRheumatology and Therapy, 2023
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage bone destruction, and joint deformation.
Ying-Li Yang   +6 more
doaj   +1 more source

Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway

open access: yesFrontiers in Pharmacology, 2021
Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for acute liver injury caused by overuse of acetaminophen (APAP). Caveolin-1 (CAV1), a regulator of hepatic energy metabolism and oxidative stress, was found to have a protective ...
Jiarong Wang   +23 more
doaj   +1 more source

PTEN Methylation Promotes Inflammation and Activation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

open access: yesFrontiers in Pharmacology, 2021
Rheumatoid arthritis (RA) is characterized by a tumor-like expansion of the synovium and subsequent destruction of adjacent articular cartilage and bone.
Xiao-Feng Li   +15 more
doaj   +1 more source

Isolation and immunocharacterization of lactobacillus salivarius from the intestine of wakame-fed pigs to develop novel "Immunosynbiotics" [PDF]

open access: yes, 2019
Emerging threats of antimicrobial resistance necessitate the exploration of effective alternatives for healthy livestock growth strategies. ?Immunosynbiotics?, a combination of immunoregulatory probiotics and prebiotics with synergistic effects when used
Albarracín, Leonardo   +12 more
core   +1 more source

Inflammation‐Controlled Anti‐Inflammatory Hydrogels

open access: yesAdvanced Science, 2023
While autoregulative adaptation is a common feature of living tissues, only a few feedback‐controlled adaptive biomaterials are available so far. This paper herein reports a new polymer hydrogel platform designed to release anti‐inflammatory molecules in
Tina Helmecke   +8 more
doaj   +1 more source

CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a

open access: yesFrontiers in Pharmacology, 2022
The activation of hepatic stellate cells (HSCs) is closely related to hepatic fibrosis and plays a key role in its occurrence and development. In the damaged liver, inhibition of the activation, proliferation, and clearance of HSCs is an important ...
Hui Liu   +30 more
doaj   +1 more source

Synthesis and bioactivity of a conjugate composed of green tea catechins and hyaluronic acid [PDF]

open access: yes, 2015
(-)-Epigallocatechin-3-gallate (EGCG) is a green tea polyphenol that has several biological activities, including anti-cancer activity and anti-inflammation.
Chung, Joo Eun   +7 more
core   +1 more source

Protein acetylation and related potential therapeutic strategies in kidney disease

open access: yesPharmacological Research, 2023
Kidney disease can be caused by various internal and external factors that have led to a continual increase in global deaths. Current treatment methods can alleviate but do not markedly prevent disease development.
Xiang-yu Li   +12 more
doaj   +1 more source

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