Results 11 to 20 of about 3,781,173 (304)

High-Fat Diet : Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse [PDF]

, 2010
Background: Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation.
Ding, Shengli, Magness, Scott, Scull, Brooks P., Jobin, Christian, Schwerbrock, Nicole M. J., Lund, Pauline K., Chi, Michael M., Rigby, Rachael   +7 more
core   +6 more sources

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]

, 2014
Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa, Pineda, Miguel A, Rodgers, David T, Harnett, Margaret, Harnett, William   +4 more
core   +3 more sources

Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

Journal of Advanced Research, 2021
Introduction: Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects.
Heng Li, Xianglei Zhang, Caigui Xiang, Chunlan Feng, Chen Fan, Moting Liu, Huimin Lu, Haixia Su, Yu Zhou, Qing Qi, Yechun Xu, Wei Tang   +11 more
doaj   +1 more source

20-hydroxyecdysone dilates muscle arterioles in a nitric oxide-dependent, estrogen ER-β receptor-independent manner

Phytomedicine Plus, 2021
Background: 20-hydroxyecdysone is an ecdysteroid which is abundant in plants and insects and has anabolic potentials in mammals. It was recently shown to have affinity for estrogen ER-β receptor, which could potentially make it vasodilatory.
Nelson N Orie, Asmaa Raees, Maneera Y. Aljaber, Nada Mohamed-Ali, Halima Bensmail, Mostafa M. Hamza, Nasser Al-Ansari, Alka Beotra, Vidya Mohamed-Ali, Mohammed Almaadheed   +9 more
doaj   +1 more source

Caveolin-1 Alleviates Acetaminophen-Induced Fat Accumulation in Non-Alcoholic Fatty Liver Disease by Enhancing Hepatic Antioxidant Ability via Activating AMPK Pathway

Frontiers in Pharmacology, 2021
Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for acute liver injury caused by overuse of acetaminophen (APAP). Caveolin-1 (CAV1), a regulator of hepatic energy metabolism and oxidative stress, was found to have a protective ...
Jiarong Wang, Jiarong Wang, Jiarong Wang, Wei Jiang, Wei Jiang, Wei Jiang, Jiao Xin, Jiao Xin, Jiao Xin, Weiju Xue, Weiju Xue, Weiju Xue, Congjian Shi, Congjian Shi, Congjian Shi, Jiagen Wen, Jiagen Wen, Jiagen Wen, Yan Huang, Yan Huang, Yan Huang, Chengmu Hu, Chengmu Hu, Chengmu Hu   +23 more
doaj   +1 more source

Nitric oxide in acute and chronic inflammation. [PDF]

, 2002
PhDNitric oxide (NO) is a signalling molecule formed when L-arginine is converted to L-citrulline by the enzyme NO synthase (NOS. NOS exists as three isoforms, ecNOS is constitutively expressed in endothelial cells and nNOS in neuronal cells, while a ...
Paul-Clark, Mark John
core   +4 more sources

CaM/CaMKII mediates activation and proliferation of hepatic stellate cells regulated by ASIC1a

Frontiers in Pharmacology, 2022
The activation of hepatic stellate cells (HSCs) is closely related to hepatic fibrosis and plays a key role in its occurrence and development. In the damaged liver, inhibition of the activation, proliferation, and clearance of HSCs is an important ...
Hui Liu, Hui Liu, Hui Liu, Wei-Li Lu, Wei-Li Lu, Wei-Li Lu, Hai-Qin Hong, Hai-Qin Hong, Hai-Qin Hong, Meng-Jun Li, Meng-Jun Li, Meng-Jun Li, Man-Ping Ye, Man-Ping Ye, Man-Ping Ye, Qiu-Fan Rao, Qiu-Fan Rao, Qiu-Fan Rao, Jin-Ling Kong, Jin-Ling Kong, Jin-Ling Kong, Shao-Hua Luan, Shao-Hua Luan, Shao-Hua Luan, Yan Huang, Yan Huang, Yan Huang, Qing-Hua Hu, Fan-Rong Wu, Fan-Rong Wu, Fan-Rong Wu   +30 more
doaj   +1 more source

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung [PDF]

, 2014
Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome,
Tait, M A, Robb, C T, Haslett, C, Duffin, R, Fox, S, Rossi, A G, Dorward, D A, Lucas, C D; id_orcid, Allen, K C, Hirani, N, Marwick, J A   +10 more
core   +1 more source

PTEN Methylation Promotes Inflammation and Activation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
Rheumatoid arthritis (RA) is characterized by a tumor-like expansion of the synovium and subsequent destruction of adjacent articular cartilage and bone.
Xiao-Feng Li, Xiao-Feng Li, Xiao-Feng Li, Sha Wu, Sha Wu, Qi Yan, Yuan-Yuan Wu, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Su-Qin Yin, Xin Chen, Xin Chen, Hua Wang, Jun Li, Jun Li   +15 more
doaj   +1 more source

Endotoxemia-induced inflammation and the effect on the human brain [PDF]

, 2010
Introduction: Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described.Methods: Experimental endotoxemia (2 ng/kg Escherichia coli ...
Verbeek, M., Hoedemaekers, C.W.E., Boogaard, Mark van den, Sieberen P van der Werf, Hoeven, J.G. van der, van der Werf, Sieberen P., Boogaard, M.H.W.A. van den, Lisette Schoonhoven, Ramakers, Bart P., Nens van Alfen, Johannes G van der Hoeven, Schoonhoven, L., Wilhelmina F Fick, Schoonhoven, Lisette, Marcel M Verbeek, Pickkers, P., van der Hoeven, Johannes G., Bart P Ramakers, Peter Pickkers, Alfen, N. van, Hoedemaekers, Cornelia W., Hoeven, Hans van der, Fick, Wilhelmina F., Ramakers, B.P.C., Van den Boogaard, Mark, Fick, W.F., Hoedemaekers, A., Fick, I., Mark van den Boogaard, Werf, S.P. van der, Verbeek, Marcel M., Cornelia W Hoedemaekers, Pickkers, Peter, van Alfen, Nens, Ramakers, B., Werf, S. van der, Verbeek, M.M.   +36 more
core   +2 more sources