Results 71 to 80 of about 1,234,464 (310)

Antidiabetic effect of Tibetan medicine Tang-Kang-Fu-San on high-fat diet and streptozotocin-induced type 2 diabetic rats [PDF]

, 2017
The aim of this study was to investigate the antidiabetic effects of a Tibetan medicine, Tang-Kang-Fu-San (TKFS), on experimental type 2 diabetes mellitus (T2DM) rats and to explore its underlying mechanisms.
Duan, Bailu, Gao, Tiexiang, Jin, Jing, Lin, Ling, Mei, Zhinan, Ta, Na, Xiong, Hui, Zhang, Lijun, Zhao, Zhongqiu   +8 more
core   +3 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Oxyresveratrol Attenuates Inflammation in Human Keratinocyte via Regulating NF-kB Signaling and Ameliorates Eczematous Lesion in DNCB-Induced Dermatitis Mice

Pharmaceutics, 2023
Oxyresveratrol (ORV) is one of the novel antioxidants having been extensively studied in recent years. One of the main sources of ORV is Artocarpus lakoocha, which has been used in traditional medicine in Thailand for decades. However, the role of ORV in
Hung Gia Tran, Aussavashai Shuayprom, Patipark Kueanjinda, Asada Leelahavanichkul, Prapai Wongsinkongman, Siriwan Chaisomboonpan, Apiwat Tawatsin, Kriangsak Ruchusatsawat, Jongkonnee Wongpiyabovorn   +8 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Lactylation: the metabolic–immune hub in autoimmune diseases

Frontiers in Immunology
In recent years, lactate modification, as an emerging post-translational modification mechanism, has attracted increasing attention for its role in the regulation of the immune system. Autoimmune diseases are a category of complex disorders characterized
Qingqing Xia, Qingqing Xia, Dantong Sun, Dantong Sun, Ke Wan, Chengcheng Liu, Han Shu, Miao Wang, Tongsheng Zhou, Tongsheng Zhou, Ying Chen, Xue Yang, Xiao-Feng Li, Xiao-Feng Li, Biao Song, Biao Song, Facai Wang, Facai Wang   +17 more
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Frontiers in Pharmacology, 2018
Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects
Heng Li, Heng Li, Jianping Zuo, Jianping Zuo, Wei Tang, Wei Tang, Wei Tang   +6 more
doaj   +1 more source

Downregulated serum 14, 15-epoxyeicosatrienoic acid is associated with abdominal aortic calcification in patients with primary aldosteronism [PDF]

, 2018
Patients with primary aldosteronism (PA) have increased risk of target-organ damage, among which vascular calcification is an important indicator of cardiovascular mortality.
Gao, Jingwei, He, Wanbing, Huang, Hui, Lin, Ying, Liu, Pinming, Shi, Guangzi, Touyz, Rhian M., Yan, Li, Zhang, Shaoling   +8 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease

Nature Communications
Renal tubulointerstitial abnormalities predict diabetic kidney disease (DKD) progression, and targeting them may prevent DKD. Insulin-like growth factor binding-protein 7 (IGFBP7) is expressed in renal tubular cells and is elevated in both blood and ...
Ju-tao Yu, Xiao-wei Hu, Jia-nan Wang, Qin Yang, Xiang-yu Li, Run-run Shan, Tian Pu, Rui Hou, Xiao-yu Shen, Yu-qin Wang, Fei Zhang, Xiao-wen Yu, Jie Wang, Feng-he Li, Jia-gen Wen, Ying Fan, Juan Jin, Yi-yang Jiang, Xiao-ming Meng   +18 more
doaj   +1 more source

Anti fungal activity of alcoholic extract of Peganum harmala seeds [PDF]

, 2011
In our study, it was aimed to determine antifungal activity of Peganum harmala on medically important yeasts and molds in vitro. Fungal suspensions of Candida spp and aspergillus spp isolated from the clinical specimens were treated with serial dilutions
Diba, K., Khorshivand, Z., Shabatkhori, M., Shoar, M.G.   +3 more
core